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FLG antibody :: Filaggrin Antibody

Scan QR to view Datasheet Catalog #    MBS439958
Unit / Price
0.02 mg (With BSA & Azide at 0.2mg/ml)  /  $190 +1 FREE 8GB USB
0.1 mg (With BSA & Azide at 0.2mg/ml)  /  $300 +1 FREE 8GB USB
0.1 mg (Without BSA & Azide at 1mg/ml)  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Filaggrin (FLG), Antibody

★Popular Item★
 Also Known As   

Filaggrin (Keratinocyte Differentiation Marker)

 Product Synonym Names    ATOD2; Epidermal Filaggrin; Filaggrin; Filaggrin precursor; Fillagrin; FLG; Profilaggrin
 Product Gene Name   

FLG antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P20930
 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    rFLG/1561
 Host    Mouse
 Species Reactivity    Human. Others not tested.
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 Specificity    Filaggrin is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Active filaggrin is present at a level of the epidermis where keratinocytes are in transition between the live nucleated granular layer and the anucleate cornified layer, suggesting that filaggrin aids in the terminal differentiation process by facilitating apoptotic machinery.
 Form/Format    200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
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 Immunogen    Recombinant fragment of human Filaggrin protein (aa 198-288)
 Cellular Localization    Cytoplasmic
 Hu-chromosome Location    1q21.3
 Positive Control    U-251-MG cells orSkin
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 Preparation and Storage    Antibody with azide - store at 2 to 8 degree C.
Antibody without azide - store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
 Other Notes    Small volumes of FLG antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for FLG antibody   

Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin

 Application Notes for FLG antibody    FC/FACS: 0.5-1ug/million cells
IF: 1-2ug/ml
IHC-F: 0.5-1ug/ml for 30 minutes at RT; Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes.
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 SDS-Page of FLG antibody    SDS-PAGE Analysis Purified Filaggrin Mouse Recombinant Monoclonal Antibody (rFLG/1561).
FLG antibody  SDS-Page image
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 Immunohistochemistry (IHC) of FLG antibody    Formalin-fixed, paraffin-embedded human Skin stained with Filaggrin Mouse Recombinant Monoclonal Antibody (rFLG/1561).
FLG antibody  Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for FLG. It may not necessarily be applicable to this product.
 NCBI GI #    60097902
 NCBI GeneID    2312
 NCBI Accession #    NP_002007.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002016.1 [Other Products]
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 UniProt Primary Accession #    P20930 [Other Products]
 UniProt Secondary Accession #    Q01720; Q5T583; Q9UC71 [Other Products]
 UniProt Related Accession #    P20930 [Other Products]
 Molecular Weight    26-45kDa (Processed); 350kDa (Profilaggrin)
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 NCBI Official Full Name    filaggrin
 NCBI Official Synonym Full Names    filaggrin
 NCBI Official Symbol    FLG [Similar Products]
 NCBI Official Synonym Symbols   
ATOD2
[Similar Products]
 NCBI Protein Information    filaggrin
 UniProt Protein Name    Filaggrin
 Protein Family    Filaggrin
 UniProt Gene Name    FLG [Similar Products]
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 NCBI Summary for FLG    The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris.[provided by RefSeq, Dec 2009]
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 UniProt Comments for FLG    Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis.
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Product References and Citations for FLG antibody

   Gan, S.Q., et al. 1990. Organization, structure, and polymorphisms of thehuman profilaggrin gene. Biochemistry 29: 9432-9440.
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 Research Articles on FLG    1. We suggest that SNP in FLG (rs11204981) may serve as an important predictive marker for the combined eczema plus asthma phenotype, and that the highest level of expression in heterozygous may have a protective role in developing allergy phenotype.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with FLG antibody Pathways associated with FLG antibody
 Reference Product  PubMed Publications
 FGFR1 antibody  >38 publications with FLG and FGFR1
 LOR antibody  >10 publications with FLG and LOR
 IVL antibody  >6 publications with FLG and IVL
 SPINK5 antibody  >5 publications with FLG and SPINK5
 EGF antibody  >5 publications with FLG and EGF
 KRT1 antibody  >1 publications with FLG and KRT1
 Products by Pathway  Pathway Diagram
 AhR Pathway antibodies  AhR Pathway Diagram
Diseases associated with FLG antibody Organs/Tissues associated with FLG antibody
 Disease Name  Pubmed Publications
 Dermatitis, Atopic Antibodies  >145 publications with FLG and Dermatitis, Atopic
 Dermatitis, Atopic, 1 Antibodies  >79 publications with FLG and Dermatitis, Atopic, 1
 Dermatitis, Atopic, 2 Antibodies  >69 publications with FLG and Dermatitis, Atopic, 2
 Eczema Antibodies  >62 publications with FLG and Eczema
 Ichthyosis Antibodies  >60 publications with FLG and Ichthyosis
 Neoplasms Antibodies  >58 publications with FLG and Neoplasms
 Ichthyosis Vulgaris Antibodies  >56 publications with FLG and Ichthyosis Vulgaris
 Lung Diseases Antibodies  >28 publications with FLG and Lung Diseases
 Inflammation Antibodies  >23 publications with FLG and Inflammation
 Necrosis Antibodies  >12 publications with FLG and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >155 publications with FLG and Skin
 Brain Antibodies  >31 publications with FLG and Brain
 Uterus Antibodies  >3 publications with FLG and Uterus
 Mouth Antibodies  >2 publications with FLG and Mouth
 Testis Antibodies  >1 publications with FLG and Testis
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