NP_001104026.1
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
filamin-A isoform 2
NCBI Official Synonym Full Names
filamin A
NCBI Official Synonym Symbols
FLN; FMD; MNS; OPD; ABPX; CSBS; CVD1; FLN1; NHBP; OPD1; OPD2; XLVD; XMVD; FLN-A; ABP-280 [Similar Products]
NCBI Protein Information
filamin-A
UniProt Protein Name
Filamin-A
UniProt Synonym Protein Names
Actin-binding protein 280; ABP-280; Alpha-filamin; Endothelial actin-binding protein; Filamin-1; Non-muscle filamin
UniProt Synonym Gene Names
NCBI Summary for FLNA
The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009]
UniProt Comments for FLNA
FLNA: a ubiquitous cytoskeletal protein that promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Plays an essential role in embryonic cell migration. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interactions with filamin A may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking.
Protein type: Actin-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: Xq28
Cellular Component: actin cytoskeleton; cell-cell adherens junction; cytoplasm; cytosol; extracellular matrix; extracellular region; filamentous actin; focal adhesion; intercellular junction; membrane; nucleolus; nucleus; plasma membrane; Z disc
Molecular Function: actin filament binding; G-protein-coupled receptor binding; glycoprotein binding; GTPase binding; kinase binding; potassium channel regulator activity; protein binding; protein homodimerization activity; Rac GTPase binding; Ral GTPase binding; Rho GTPase binding; signal transducer activity; small GTPase binding; transcription factor binding
Biological Process: actin crosslink formation; actin cytoskeleton reorganization; cytoplasmic sequestering of protein; dopamine receptor, adenylate cyclase inhibiting pathway; establishment of protein localization; negative regulation of apoptosis; negative regulation of protein catabolic process; negative regulation of transcription factor activity; negative regulation of transcription from RNA polymerase I promoter; platelet activation; platelet degranulation; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of transcription factor import into nucleus; protein stabilization; receptor clustering; regulation of cell migration
Disease: Cardiac Valvular Dysplasia, X-linked; Fg Syndrome 2; Frontometaphyseal Dysplasia; Heterotopia, Periventricular, Ehlers-danlos Variant; Heterotopia, Periventricular, X-linked Dominant; Intestinal Pseudoobstruction, Neuronal, Chronic Idiopathic, X-linked; Melnick-needles Syndrome; Otopalatodigital Syndrome, Type I; Otopalatodigital Syndrome, Type Ii; Terminal Osseous Dysplasia
Research Articles on FLNA
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with anti-FLNA antibody
Pathways associated with anti-FLNA antibody
Diseases associated with anti-FLNA antibody
Organs/Tissues associated with anti-FLNA antibody
|