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anti-GAS6 antibody :: Rabbit anti-Human GAS6 Antibody

Scan QR to view Datasheet Catalog #    MBS854847
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GAS6, Antibody

 Also Known As   

GAS6 Antibody

 Product Synonym Names    GAS-6; AXL receptor; tyrosine kinase ligand
 Product Gene Name   

anti-GAS6 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    600441
 3D Structure    ModBase 3D Structure for Q14393
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 Host    Rabbit
 Species Reactivity    Human
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 Specificity    GAS6 antibody detects endogenous levels of total GAS6 protein.
 Purity/Purification    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Immunogen    The antiserum was produced against synthesized peptide derived from internal of human GAS6.
 Pathway    Cancer/Apoptosis
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 Preparation and Storage    Store at -20 degree C for 1 year
 Other Notes    Small volumes of anti-GAS6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-GAS6 antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-GAS6 antibody   

Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)

 Application Notes for anti-GAS6 antibody    WB: 1:500~1:1000, IHC: 1:50~1:100, ELISA: 1:40000
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 Testing Data of anti-GAS6 antibody    anti-GAS6 antibody Testing Data image
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 Testing Data #2 of anti-GAS6 antibody    Immunohistochemistry analysis of paraffin-embedded human brain tissue using GAS6 antibody.
Western blot analysis of extracts from 293 cells, using GAS6 antibody.
anti-GAS6 antibody Testing Data #2 image
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NCBI/Uniprot data below describe general gene information for GAS6. It may not necessarily be applicable to this product.
 NCBI GI #    4557617
 NCBI GeneID    2621
 NCBI Accession #    NP_000811.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000820.3 [Other Products]
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 UniProt Primary Accession #    Q14393 [Other Products]
 UniProt Secondary Accession #    Q6IMN1; Q7Z7N3; B3KRQ7; B3KVL4; E9PBL7 [Other Products]
 UniProt Related Accession #    Q14393 [Other Products]
 Molecular Weight    41,986 Da
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 NCBI Official Full Name    growth arrest-specific protein 6
 NCBI Official Synonym Full Names    growth arrest-specific 6
 NCBI Official Symbol    GAS6 [Similar Products]
 NCBI Official Synonym Symbols   
AXSF; AXLLG
[Similar Products]
 NCBI Protein Information    growth arrest-specific protein 6; AXL stimulatory factor; AXL receptor tyrosine kinase ligand
 UniProt Protein Name    Growth arrest-specific protein 6
 UniProt Synonym Protein Names   
AXL receptor tyrosine kinase ligand
 Protein Family    Growth arrest-specific protein
 UniProt Gene Name    GAS6 [Similar Products]
 UniProt Synonym Gene Names    AXLLG; GAS-6 [Similar Products]
 UniProt Entry Name    GAS6_HUMAN
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 NCBI Summary for GAS6    This gene encodes a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the stimulation of cell proliferation. This gene is frequently overexpressed in many cancers and has been implicated as an adverse prognostic marker. Elevated protein levels are additionally associated with a variety of disease states, including venous thromboembolic disease, systemic lupus erythematosus, chronic renal failure, and preeclampsia. [provided by RefSeq, Aug 2014]
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 UniProt Comments for GAS6    GAS6: Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted; Ligand, receptor tyrosine kinase

Chromosomal Location of Human Ortholog: 13q34

Cellular Component: extracellular space; endoplasmic reticulum lumen; Golgi lumen; cytoplasm; extracellular region

Molecular Function: voltage-gated calcium channel activity; protein binding; phosphatidylserine binding; caspase inhibitor activity; protein tyrosine kinase activator activity; calcium ion binding; receptor tyrosine kinase binding; receptor agonist activity; molecular adaptor activity; receptor binding

Biological Process: proteolysis; protein amino acid phosphorylation; enzyme linked receptor protein signaling pathway; positive regulation of fibroblast proliferation; viral envelope fusion with host membrane; negative regulation of protein import into nucleus, translocation; positive regulation of phagocytosis; regulation of growth; negative regulation of interleukin-6 production; cell cycle arrest; cell adhesion; positive regulation of TOR signaling pathway; platelet activation; organ regeneration; activation of protein kinase B; negative regulation of transcription factor activity; cellular response to starvation; peptidyl-glutamic acid carboxylation; negative regulation of transcription, DNA-dependent; leukocyte migration; negative regulation of interleukin-1 secretion; negative regulation of apoptosis; entry of virus into host cell; neuron migration; negative regulation of caspase activity; signal transduction; positive regulation of protein export from nucleus; positive regulation of natural killer cell differentiation; platelet degranulation; positive regulation of glomerular filtration; negative regulation of interferon-gamma production; protein kinase B signaling cascade; virion attachment, binding of host cell surface receptor; cell migration; negative regulation of tumor necrosis factor production; viral genome replication; post-translational protein modification; positive regulation of peptidyl-serine phosphorylation; phagocytosis; cell-substrate adhesion; cell proliferation; positive regulation of protein kinase B signaling cascade; peptidyl-serine phosphorylation; cellular protein metabolic process; positive regulation of protein kinase activity; positive regulation of protein amino acid phosphorylation; blood coagulation; positive regulation of cytokine and chemokine mediated signaling pathway; apoptotic cell clearance
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Product References and Citations for anti-GAS6 antibody

   Manfioletti G., Mol. Cell. Biol. 13:4976-4985(1993).
Ota T., Nat. Genet. 36:40-45(2004).
Varnum B.C., Nature 373:623-626(1995).
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 Research Articles on GAS6    1. The Gas6/Axl signaling pathway is involved in high glucose induced endothelial dysfunction.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-GAS6 antibodyPathways associated with anti-GAS6 antibody
 Reference Product  PubMed Publications
 AXL antibody  >256 publications with GAS6 and AXL
 TYRO3 antibody  >99 publications with GAS6 and TYRO3
 MERTK antibody  >69 publications with GAS6 and MERTK
 TGFB1 antibody  >3 publications with GAS6 and TGFB1
 SPARC antibody  >2 publications with GAS6 and SPARC
 SERPINE1 antibody  >2 publications with GAS6 and SERPINE1
 GGCX antibody  >1 publications with GAS6 and GGCX
 FN1 antibody  >1 publications with GAS6 and FN1
 Products by Pathway  Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Gamma-carboxylation Of Protein Precursors Pathway antibodies  Gamma-carboxylation Of Protein Precursors Pathway Diagram
 Gamma-carboxylation, Transport, And Amino-terminal Cleavage Of Proteins Pathway antibodies  Gamma-carboxylation, Transport, And Amino-terminal Cleavage Of Proteins Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 PTM: Gamma Carboxylation, Hypusine Formation And Arylsulfatase Activation Pathway antibodies  PTM: Gamma Carboxylation, Hypusine Formation And Arylsulfatase Activation Pathway Diagram
 Platelet Activation, Signaling And Aggregation Pathway antibodies  Platelet Activation, Signaling And Aggregation Pathway Diagram
 Platelet Degranulation Pathway antibodies  Platelet Degranulation Pathway Diagram
 Post-translational Protein Modification Pathway antibodies  Post-translational Protein Modification Pathway Diagram
 Removal Of Aminoterminal Propeptides From Gamma-carboxylated Proteins Pathway antibodies  Removal Of Aminoterminal Propeptides From Gamma-carboxylated Proteins Pathway Diagram
Diseases associated with anti-GAS6 antibodyOrgans/Tissues associated with anti-GAS6 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >58 publications with GAS6 and Inflammation
 Cardiovascular Diseases Antibodies  >52 publications with GAS6 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >31 publications with GAS6 and Disease Models, Animal
 Necrosis Antibodies  >29 publications with GAS6 and Necrosis
 Thrombosis Antibodies  >29 publications with GAS6 and Thrombosis
 Kidney Diseases Antibodies  >26 publications with GAS6 and Kidney Diseases
 Neoplasms, Experimental Antibodies  >14 publications with GAS6 and Neoplasms, Experimental
 Adenocarcinoma Antibodies  >11 publications with GAS6 and Adenocarcinoma
 Breast Neoplasms Antibodies  >10 publications with GAS6 and Breast Neoplasms
 Heart Diseases Antibodies  >9 publications with GAS6 and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >110 publications with GAS6 and Blood
 Vascular Antibodies  >82 publications with GAS6 and Vascular
 Muscle Antibodies  >45 publications with GAS6 and Muscle
 Bone Antibodies  >44 publications with GAS6 and Bone
 Kidney Antibodies  >35 publications with GAS6 and Kidney
 Brain Antibodies  >27 publications with GAS6 and Brain
 Bone Marrow Antibodies  >26 publications with GAS6 and Bone Marrow
 Liver Antibodies  >22 publications with GAS6 and Liver
 Lung Antibodies  >18 publications with GAS6 and Lung
 Eye Antibodies  >15 publications with GAS6 and Eye
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