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GFAP antibody

Scan QR to view Datasheet Catalog #    MBS438192
Immunohistochemistry (IHC)
Unit / Price
0.02 mg (With BSA & Azide at 0.2mg/ml)  /  $150 +1 FREE 8GB USB
7 ml (Prediluted)  /  $270 +1 FREE 8GB USB
0.1 mg (With BSA & Azide at 0.2mg/ml)  /  $270 +1 FREE 8GB USB
0.1 mg (Without BSA & Azide at 1mg/ml)  /  $285 +1 FREE 8GB USB
0.2 mg (With BSA & Azide at 0.2mg/ml)  /  $360 +1 FREE 8GB USB
0.2 mg (Without BSA & Azide at 1mg/ml)  /  $380 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GFAP, Antibody

★Popular Item★
 Also Known As   

GFAP (Astrocyte & Neural Stem Cell Marker) Mouse Monoclonal Antibody

 Product Synonym Names    Astrocyte or Intermediate Filament Protein, Glial Fibrillary Acidic Protein
 Product Gene Name   

GFAP antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    137780
 3D Structure    ModBase 3D Structure for P14136
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    SPM507
 Host    Mouse
 Species Reactivity    Human, Mouse, Rat, Cow, Pig, Rabbit, Chicken
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 Specificity    This MAb recognizes a protein of ~50kDa which is identified as Glial Fibrillary Acidic Protein (GFAP). It shows no cross-reaction with other intermediate filament proteins. GFAP is specifically found in astroglia. GFAP is a very popular marker for localizing benign astrocyte and neoplastic cells of glial origin in the central nervous system. Antibody to GFAP is useful in differentiating primary gliomas from metastatic lesions in the brain and for documenting astrocytic differentiation in tumors outside the CNS.
 Form/Format    200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
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 Cellular Localization    Cytoplasmic
 Immunogen    GFAP isolated from pig spinal cord
 Hu-Chromosome Location    17q21.31
 Positive Control    Brain or Astrocytoma
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 Preparation and Storage    Antibody without azide - store at -20 to -80 degree C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
 Other Notes    Small volumes of GFAP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for GFAP antibody   

Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB), Immunohistochemistry (IHC) Formalin

 Application Notes for GFAP antibody    Flow Cytometry (0.5-1ug/million cells in 0.1ml)
Immunofluorescence (1-2ug/ml)
Western Blot (0.5-1ug/ml)
Immunohistochemistry (Formalin-fixed) (0.25-0.5ug/ml for 30 minutes at RT) (Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)
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 Immunohistochemistry (IHC) of GFAP antibody    Formalin-fixed, paraffin-embedded human Cerebellum stained with GFAP Monoclonal Antibody (SPM507).
GFAP antibody  Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for GFAP. It may not necessarily be applicable to this product.
 NCBI GI #    196115290
 NCBI GeneID    2670
 NCBI Accession #    NP_001124491.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001131019.2 [Other Products]
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 UniProt Primary Accession #    P14136 [Other Products]
 UniProt Secondary Accession #    Q53H98; Q5D055; Q6ZQS3; Q7Z5J6; Q7Z5J7; Q96KS4; Q96P18; Q9UFD0; B2RD44; D3DX59; E9PAX3 [Other Products]
 UniProt Related Accession #    P14136 [Other Products]
 Molecular Weight    ~50kDa
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 NCBI Official Full Name    glial fibrillary acidic protein isoform 2
 NCBI Official Synonym Full Names    glial fibrillary acidic protein
 NCBI Official Symbol    GFAP [Similar Products]
 NCBI Official Synonym Symbols   
ALXDRD
[Similar Products]
 NCBI Protein Information    glial fibrillary acidic protein
 UniProt Protein Name    Glial fibrillary acidic protein
 Protein Family    Glial fibrillary acidic protein
 UniProt Gene Name    GFAP [Similar Products]
 UniProt Synonym Gene Names    GFAP [Similar Products]
 UniProt Entry Name    GFAP_HUMAN
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 NCBI Summary for GFAP    This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]
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 UniProt Comments for GFAP    GFAP: a class-III intermediate filament protein. A cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. An additional transcript variant isoform has been described, but its full length sequence has not been determined.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 17q21

Cellular Component: cytoplasm; cytosol; intermediate filament cytoskeleton; lysosome

Molecular Function: protein binding

Biological Process: regulation of protein complex assembly

Disease: Alexander Disease
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Product References and Citations for GFAP antibody

   Herpers MJ et. Al. 1986, Acta Neuropathol, 70:333-339. Van Muijen GN et. al. 1987, Lab Invest, 57:359-369. Debus E, et. al. 1983, Differentiation, 25(2):193-203
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 Research Articles on GFAP    1. Neither duplications nor deletions of GFAP were found, suggesting that GFAP coding-region rearrangements may not be involved in Alexander disease or Alexanderrelated leukoencephalopathies.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with GFAP antibody Pathways associated with GFAP antibody
 Reference Product  PubMed Publications
 S100B antibody  >209 publications with GFAP and S100B
 SRC antibody  >27 publications with GFAP and SRC
 PSEN1 antibody  >17 publications with GFAP and PSEN1
 S100A1 antibody  >12 publications with GFAP and S100A1
 PRNP antibody  >11 publications with GFAP and PRNP
 RBFOX3 antibody  >3 publications with GFAP and RBFOX3
 PSEN2 antibody  >1 publications with GFAP and PSEN2
 CDK1 antibody  >1 publications with GFAP and CDK1
 NCOR1 antibody  >1 publications with GFAP and NCOR1
 Products by Pathway  Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Neural Crest Differentiation Pathway antibodies  Neural Crest Differentiation Pathway Diagram
 Nuclear Signaling By ERBB4 Pathway antibodies  Nuclear Signaling By ERBB4 Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By ERBB4 Pathway antibodies  Signaling By ERBB4 Pathway Diagram
 Spinal Cord Injury Pathway antibodies  Spinal Cord Injury Pathway Diagram
Diseases associated with GFAP antibody Organs/Tissues associated with GFAP antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >5370 publications with GFAP and Nervous System Diseases
 Brain Diseases Antibodies  >4063 publications with GFAP and Brain Diseases
 Disease Models, Animal Antibodies  >1666 publications with GFAP and Disease Models, Animal
 Gliosis Antibodies  >1205 publications with GFAP and Gliosis
 Cardiovascular Diseases Antibodies  >982 publications with GFAP and Cardiovascular Diseases
 Inflammation Antibodies  >784 publications with GFAP and Inflammation
 Brain Injuries Antibodies  >773 publications with GFAP and Brain Injuries
 Necrosis Antibodies  >660 publications with GFAP and Necrosis
 Nerve Degeneration Antibodies  >569 publications with GFAP and Nerve Degeneration
 Pain Antibodies  >403 publications with GFAP and Pain
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >8585 publications with GFAP and Brain
 Nerve Antibodies  >3619 publications with GFAP and Nerve
 Blood Antibodies  >1776 publications with GFAP and Blood
 Spinal Cord Antibodies  >1535 publications with GFAP and Spinal Cord
 Eye Antibodies  >1083 publications with GFAP and Eye
 Muscle Antibodies  >557 publications with GFAP and Muscle
 Ganglia Antibodies  >319 publications with GFAP and Ganglia
 Bone Marrow Antibodies  >274 publications with GFAP and Bone Marrow
 Liver Antibodies  >226 publications with GFAP and Liver
 Connective Tissue Antibodies  >211 publications with GFAP and Connective Tissue
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