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anti-GFAP antibody :: Rabbit GFAP Antibody

Scan QR to view Datasheet Catalog #    MBS541680
Western Blot
Unit / Price
0.1 mg Biotin  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GFAP, Antibody

★Popular Item★
 Also Known As   

Rabbit Polyclonal GFAP Antibody BIOTIN

 Product Synonym Names    Astrocyte; FLJ42474; FLJ45472; GFAP; Glial Fibrillary Acidic Protein; Intermediate filament protein antibody
 Product Gene Name   

anti-GFAP antibody

[Similar Products]
 Matching Pairs    Antibody: GFAP (MBS541680)
Positive Control: GFAP (MBS542796)
 Antibody/Peptide Pairs    GFAP peptide (MBS543748) is used for blocking the activity of GFAP antibody (MBS541680)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    137780
 3D Structure    ModBase 3D Structure for P14136
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 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Form/Format    BIOTIN-Conjugated Immunoglobulins
 Concentration    0.75 mg/mL IgG In antibody stabilization buffer. (lot specific)
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 Immunogen    Synthetic peptide taken within amino acid region 50-100 on human glial fibrillary acidic protein.
    
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 Preparation and Storage    -20C for long term storage.
 Other Notes    Small volumes of anti-GFAP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-GFAP antibody

   Glial fibrillary acidic protein, or GFAP, is an intermediate filament(IF) protein belongin to the type III subclass of IF protein. Like other IF proteins, GFAP is coposed of an amino-terminal head domain, a central rod domain and a carboxy-terminal tail domain. GFAP is specifically found in astroglia, a cell type which is higly responsive to neurologic insults. Astrogliosis is found to be result of mechanical trauma,AIDS dementia, prion infection and inflammatory demylination diseases, and is accompanied by an increase in GFAP EXPRESSION, GFAP is an immunohistochemical marker for localizing bening astrocyte and neoplastic cells of glian origin in the central nervous system. Glial cells are responsible for mantaining brain homeostasis.Modification of the viability and fuctionsof glial cells, including astrocytes and microglia, are associated with neuronal death and neurological diseases.

GFAP-selective antibodies were generated against a peptide taken the C-terminal region of the human GFAP protein. The GFAP-selective antibodies are affinity purified of an immobilized antigen based affinity matrix,the isolated antibodies are fully characterized for applications in western blotting and ELISA at the recommended dilutions. Western blot positive control(PC-GFAP)and antigenic blocking peptides(P-GFAP)for GFAP are available. Antibodies can be conjugated to flurophores or other secondary enzymes upon request as an additional service.
 Applications Tested/Suitable for anti-GFAP antibody   

ELISA,IHC,IP,WB

 Application Notes for anti-GFAP antibody    Dot Blot: 1:10,000
ELISA: 1:10,000
Immunohistochemistry: 1:100
Immunoprecipitation: 1:150
Western Blot: 1:500
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 Western Blot of anti-GFAP antibody    WB of Glial Fibrillary Acidic Protein (GFAP) Blot with rat cortex (1) and cerebellum (2). Primary Antibody MBS540883 diluted 1 :500 in DiluObuffer. Apparent MW is 51 kDa.
Dilutions are for reference only. Applications not listed above are not necessarily precluded from working with this antibody. Investigators intending to use an application that has not been verified can request a complimentary sample.
anti-GFAP antibody Western Blot (WB) image
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NCBI/Uniprot data below describe general gene information for GFAP. It may not necessarily be applicable to this product.
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 UniProt Primary Accession #    P14136 [Other Products]
 UniProt Secondary Accession #    Q53H98; Q5D055; Q6ZQS3; Q7Z5J6; Q7Z5J7; Q96KS4; Q96P18; Q9UFD0; B2RD44; D3DX59; E9PAX3 [Other Products]
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 UniProt Protein Name    Glial fibrillary acidic protein
 Protein Family    Glial fibrillary acidic protein
 UniProt Gene Name    GFAP [Similar Products]
 UniProt Synonym Gene Names    GFAP [Similar Products]
 UniProt Entry Name    GFAP_HUMAN
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 UniProt Comments for GFAP    GFAP: a class-III intermediate filament protein. A cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. An additional transcript variant isoform has been described, but its full length sequence has not been determined.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 17q21

Cellular Component: cytoplasm; cytosol; intermediate filament; intermediate filament cytoskeleton; lysosome; membrane; myelin sheath

Molecular Function: glycoprotein binding; integrin binding; kinase binding; protein binding; structural constituent of cytoskeleton

Biological Process: astrocyte development; Bergmann glial cell differentiation; extracellular matrix organization and biogenesis; intermediate filament organization; neurite regeneration; regulation of neurotransmitter uptake; regulation of protein complex assembly; response to wounding

Disease: Alexander Disease
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-GFAP antibodyDiseases associated with anti-GFAP antibody
 Reference Product  PubMed Publications
 S100B antibody  >209 publications with GFAP and S100B
 SRC antibody  >27 publications with GFAP and SRC
 PSEN1 antibody  >17 publications with GFAP and PSEN1
 S100A1 antibody  >12 publications with GFAP and S100A1
 PRNP antibody  >11 publications with GFAP and PRNP
 RBFOX3 antibody  >3 publications with GFAP and RBFOX3
 PSEN2 antibody  >1 publications with GFAP and PSEN2
 CDK1 antibody  >1 publications with GFAP and CDK1
 NCOR1 antibody  >1 publications with GFAP and NCOR1
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >5342 publications with GFAP and Nervous System Diseases
 Brain Diseases Antibodies  >4045 publications with GFAP and Brain Diseases
 Disease Models, Animal Antibodies  >1649 publications with GFAP and Disease Models, Animal
 Gliosis Antibodies  >1197 publications with GFAP and Gliosis
 Cardiovascular Diseases Antibodies  >976 publications with GFAP and Cardiovascular Diseases
 Inflammation Antibodies  >778 publications with GFAP and Inflammation
 Brain Injuries Antibodies  >769 publications with GFAP and Brain Injuries
 Necrosis Antibodies  >650 publications with GFAP and Necrosis
 Nerve Degeneration Antibodies  >564 publications with GFAP and Nerve Degeneration
 Epilepsy Antibodies  >402 publications with GFAP and Epilepsy
Organs/Tissues associated with anti-GFAP antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >8536 publications with GFAP and Brain
 Nerve Antibodies  >3604 publications with GFAP and Nerve
 Blood Antibodies  >1762 publications with GFAP and Blood
 Spinal Cord Antibodies  >1521 publications with GFAP and Spinal Cord
 Eye Antibodies  >1076 publications with GFAP and Eye
 Muscle Antibodies  >556 publications with GFAP and Muscle
 Ganglia Antibodies  >318 publications with GFAP and Ganglia
 Bone Marrow Antibodies  >271 publications with GFAP and Bone Marrow
 Liver Antibodies  >223 publications with GFAP and Liver
 Connective Tissue Antibodies  >210 publications with GFAP and Connective Tissue
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