NP_001138925.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
GDNF family receptor alpha-1 isoform b
NCBI Official Synonym Full Names
GDNF family receptor alpha 1
NCBI Official Synonym Symbols
GDNFR; RET1L; RETL1; TRNR1; GDNFRA; GFR-ALPHA-1 [Similar Products]
NCBI Protein Information
GDNF family receptor alpha-1
UniProt Protein Name
GDNF family receptor alpha-1
UniProt Synonym Protein Names
RET ligand 1; TGF-beta-related neurotrophic factor receptor 1
UniProt Synonym Gene Names
GDNFRA; RETL1; TRNR1; GDNF receptor alpha-1; GDNFR-alpha-1; GFR-alpha-1 [Similar Products]
NCBI Summary for GFRA1
This gene encodes a member of the glial cell line-derived neurotrophic factor receptor (GDNFR) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature receptor. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. This receptor is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]
UniProt Comments for GFRA1
GFRA1: Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. Belongs to the GDNFR family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, GPI anchor; Receptor, misc.
Chromosomal Location of Human Ortholog: 10q25.3
Cellular Component: extrinsic to membrane; plasma membrane
Molecular Function: glial cell line-derived neurotrophic factor receptor activity; Ras guanyl-nucleotide exchange factor activity; receptor binding
Biological Process: MAPKKK cascade
Research Articles on GFRA1
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Products associated with anti-GFRA1 antibody
Pathways associated with anti-GFRA1 antibody
Diseases associated with anti-GFRA1 antibody
Organs/Tissues associated with anti-GFRA1 antibody
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