NP_000155.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
53,157 Da
NCBI Official Full Name
gastric inhibitory polypeptide receptor
NCBI Official Synonym Full Names
gastric inhibitory polypeptide receptor
NCBI Official Synonym Symbols
NCBI Protein Information
gastric inhibitory polypeptide receptor; GIP-R; glucose-dependent insulinotropic polypeptide receptor
UniProt Protein Name
Gastric inhibitory polypeptide receptor
UniProt Synonym Protein Names
Glucose-dependent insulinotropic polypeptide receptor
UniProt Synonym Gene Names
UniProt Entry Name
GIPR_HUMAN
NCBI Summary for GIPR
This gene encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes. [provided by RefSeq, Oct 2011]
UniProt Comments for GIPR
GIPR: This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 2 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: GPCR, family 2; Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 19q13.3
Cellular Component: integral to membrane; plasma membrane
Molecular Function: gastric inhibitory peptide receptor activity; transmembrane receptor activity; peptide hormone binding
Biological Process: elevation of cytosolic calcium ion concentration; desensitization of G-protein coupled receptor protein signaling pathway; generation of precursor metabolites and energy; cell surface receptor linked signal transduction; adenylate cyclase activation; response to glucose stimulus; positive regulation of insulin secretion; response to axon injury; response to calcium ion; endocrine pancreas development; response to nutrient
Research Articles on GIPR
Precautions
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Products associated with anti-GIPR antibody
Pathways associated with anti-GIPR antibody
Diseases associated with anti-GIPR antibody
Organs/Tissues associated with anti-GIPR antibody
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