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anti-GLR antibody :: Rabbit GLR Antibody

Scan QR to view Datasheet Catalog #    MBS853441
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GLR, Antibody

 Also Known As   

GLR Antibody

 Product Synonym Names    Glucagon receptor [Precursor]; GL-R; GCGR
 Product Gene Name   

anti-GLR antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    138033
 3D Structure    ModBase 3D Structure for P47871
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 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    GLR antibody detects endogenous levels of total GLR protein.
 Purity/Purification    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Immunogen    The antiserum was produced against synthesized peptide derived from internal of human GLR.
 Pathway    GPCR
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 Preparation and Storage    Store at -20 degree C for 1 year
 Other Notes    Small volumes of anti-GLR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-GLR antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-GLR antibody   

Western Blot (WB), Immunofluorescence (IF), ELISA (EIA)

 Application Notes for anti-GLR antibody    WB: 1:500~1:1000, IF: 1:100~1:500, ELISA: 1:1000
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 Testing Data of anti-GLR antibody    anti-GLR antibody Testing Data image
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 Testing Data #2 of anti-GLR antibody    Peptide - +
Western blot analysis of extracts from COLO205 cells, using GLR antibody.
Immunofluorescence analysis of HeLa cells, using GLR antibody.
anti-GLR antibody Testing Data #2 image
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NCBI/Uniprot data below describe general gene information for GLR. It may not necessarily be applicable to this product.
 NCBI GI #    4503947
 NCBI GeneID    2642
 NCBI Accession #    NP_000151.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000160.4 [Other Products]
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 UniProt Primary Accession #    P47871 [Other Products]
 UniProt Secondary Accession #    Q2M3M5 [Other Products]
 UniProt Related Accession #    P47871 [Other Products]
 Molecular Weight    54,009 Da
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 NCBI Official Full Name    glucagon receptor
 NCBI Official Synonym Full Names    glucagon receptor
 NCBI Official Symbol    GCGR [Similar Products]
 NCBI Official Synonym Symbols   
GGR; GL-R
[Similar Products]
 NCBI Protein Information    glucagon receptor
 UniProt Protein Name    Glucagon receptor
 UniProt Gene Name    GCGR [Similar Products]
 UniProt Synonym Gene Names    GL-R [Similar Products]
 UniProt Entry Name    GLR_HUMAN
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 NCBI Summary for GLR    The protein encoded by this gene is a glucagon receptor that is important in controlling blood glucose levels. Defects in this gene are a cause of non-insulin-dependent diabetes mellitus (NIDDM).[provided by RefSeq, Jan 2010]
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 UniProt Comments for GLR    GCGR: This is a receptor for glucagon which plays a central role in regulating the level of blood glucose by controlling the rate of hepatic glucose production and insulin secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 2 family.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR; GPCR, family 2

Chromosomal Location of Human Ortholog: 17q25

Cellular Component: integral to plasma membrane; plasma membrane; integral to membrane; endosome

Molecular Function: guanyl-nucleotide exchange factor activity; peptide hormone binding; glucagon receptor activity

Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; response to starvation; generation of precursor metabolites and energy; exocytosis; hormone-mediated signaling; regulation of blood pressure; energy reserve metabolic process; glucose homeostasis; G-protein signaling, adenylate cyclase activating pathway; response to nutrient; positive regulation of GTPase activity

Disease: Diabetes Mellitus, Noninsulin-dependent
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Product References and Citations for anti-GLR antibody

   Macneil D.J., Biochem. Biophys. Res. Commun. 198:328-334(1994).
Lok S., Gene 140:203-209(1994).
Menzel S., Genomics 20:327-328(1994).
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 Research Articles on GLR    1. crystal structure of the seven transmembrane helical domain of human GCGR at 3.4 A resolution, and a hybrid model of glucagon bound to GCGR to understand the molecular recognition of the receptor for its native ligand
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-GLR antibodyPathways associated with anti-GLR antibody
 Reference Product  PubMed Publications
 GCG antibody  >5 publications with GLR and GCG
 PTH antibody  >1 publications with GLR and PTH
 Products by Pathway  Pathway Diagram
 Class B/2 (Secretin Family Receptors) Pathway antibodies  Class B/2 (Secretin Family Receptors) Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class B Secretin-like Pathway antibodies  GPCRs, Class B Secretin-like Pathway Diagram
 Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies  Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
 Glucagon Signaling In Metabolic Regulation Pathway antibodies  Glucagon Signaling In Metabolic Regulation Pathway Diagram
 Glucagon-type Ligand Receptors Pathway antibodies  Glucagon-type Ligand Receptors Pathway Diagram
 Integration Of Energy Metabolism Pathway antibodies  Integration Of Energy Metabolism Pathway Diagram
Diseases associated with anti-GLR antibodyOrgans/Tissues associated with anti-GLR antibody
 Disease Name  Pubmed Publications
 Hyperplasia Antibodies  >15 publications with GLR and Hyperplasia
 Diabetes Mellitus, Type 2 Antibodies  >11 publications with GLR and Diabetes Mellitus, Type 2
 Weight Loss Antibodies  >9 publications with GLR and Weight Loss
 Liver Diseases Antibodies  >6 publications with GLR and Liver Diseases
 Fatty Liver Antibodies  >5 publications with GLR and Fatty Liver
 Cardiovascular Diseases Antibodies  >4 publications with GLR and Cardiovascular Diseases
 Liver Neoplasms Antibodies  >2 publications with GLR and Liver Neoplasms
 Inflammation Antibodies  >2 publications with GLR and Inflammation
 Necrosis Antibodies  >2 publications with GLR and Necrosis
 Drug-Induced Liver Injury Antibodies  >2 publications with GLR and Drug-Induced Liver Injury
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >29 publications with GLR and Liver
 Pancreas Antibodies  >20 publications with GLR and Pancreas
 Kidney Antibodies  >3 publications with GLR and Kidney
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