NP_001070659.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
35,248 Da
NCBI Official Full Name
G-protein coupled bile acid receptor 1
NCBI Official Synonym Full Names
G protein-coupled bile acid receptor 1
NCBI Official Synonym Symbols
BG37; TGR5; M-BAR; GPCR19; GPR131 [Similar Products]
NCBI Protein Information
G-protein coupled bile acid receptor 1
UniProt Protein Name
G-protein coupled bile acid receptor 1
UniProt Synonym Protein Names
G-protein coupled receptor GPCR19; hGPCR19; Membrane-type receptor for bile acids; M-BAR; hBG37; BG37
UniProt Synonym Gene Names
NCBI Summary for GPBAR
This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
UniProt Comments for GPBAR
Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids.
Product References and Citations for anti-GPBAR antibody
Maruyama T., Biochem. Biophys. Res. Commun. 298:714-719(2002). Kawamata Y., J. Biol. Chem. 278:9435-9440(2003). Takeda S., FEBS Lett. 520:97-101(2002).
Research Articles on GPBAR
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Pathways associated with anti-GPBAR antibody
Diseases associated with anti-GPBAR antibody
Organs/Tissues associated with anti-GPBAR antibody
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