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anti-GPR109 antibody :: Rabbit GPR109 Antibody

Scan QR to view Datasheet Catalog #    MBS856615
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GPR109, Antibody

 Also Known As   

GPR109 Antibody

 Product Synonym Names    Nicotinic acid receptor 2; G-protein coupled receptor 109B; G-protein coupled receptor HM74B; G-protein coupled receptor HM74; GPR109B
 Product Gene Name   

anti-GPR109 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    606039
 3D Structure    ModBase 3D Structure for P49019
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 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    GPR109 antibody detects endogenous levels of total GPR109 protein.
 Purity/Purification    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Immunogen    The antiserum was produced against synthesized peptide derived from internal of human GPR109.
 Pathway    GPCR
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 Preparation and Storage    Store at -20 degree C for 1 year
 Other Notes    Small volumes of anti-GPR109 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-GPR109 antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-GPR109 antibody   

Western Blot (WB), Immunofluorescence (IF), ELISA (EIA)

 Application Notes for anti-GPR109 antibody    WB: 1:500~1:1000, IF: 1:100~1:500, ELISA: 1:10000
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 Testing Data of anti-GPR109 antibody    anti-GPR109 antibody Testing Data image
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 Testing Data #2 of anti-GPR109 antibody    Peptide - +
Western blot analysis of extracts from RAW264.7 cells, using GPR109 antibody.
Immunofluorescence analysis of MCF-7 cells, using GPR109 antibody.
anti-GPR109 antibody Testing Data #2 image
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NCBI/Uniprot data below describe general gene information for GPR109. It may not necessarily be applicable to this product.
 NCBI GI #    157738694
 NCBI GeneID    8843
 NCBI Accession #    NP_006009.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_006018.2 [Other Products]
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 UniProt Primary Accession #    P49019 [Other Products]
 UniProt Secondary Accession #    Q8NGE4; A8K4G5; B2R830; E9PI97 [Other Products]
 UniProt Related Accession #    P49019 [Other Products]
 Molecular Weight    44,478 Da
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 NCBI Official Full Name    hydroxycarboxylic acid receptor 3
 NCBI Official Synonym Full Names    hydroxycarboxylic acid receptor 3
 NCBI Official Symbol    HCAR3 [Similar Products]
 NCBI Official Synonym Symbols   
HCA3; HM74; PUMAG; Puma-g; GPR109B
[Similar Products]
 NCBI Protein Information    hydroxycarboxylic acid receptor 3; niacin receptor 2; GTP-binding protein; nicotinic acid receptor 2; putative chemokine receptor; G protein-coupled receptor 109B; G-protein coupled receptor 109B; G-protein coupled receptor HM74; G-protein coupled receptor HM74B; hydroxy-carboxylic acid receptor 3
 UniProt Protein Name    Hydroxycarboxylic acid receptor 3
 UniProt Synonym Protein Names   
G-protein coupled receptor 109B; G-protein coupled receptor HM74; G-protein coupled receptor HM74B; Niacin receptor 2; Nicotinic acid receptor 2
 UniProt Gene Name    HCAR3 [Similar Products]
 UniProt Synonym Gene Names    GPR109B; HCA3; HM74B; NIACR2 [Similar Products]
 UniProt Entry Name    HCAR3_HUMAN
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 UniProt Comments for GPR109    GPR109B: Receptor for 3-OH-octanoid acid mediates a negative feedback regulation of adipocyte lipolysis to counteract prolipolytic influences under conditions of physiological or pathological increases in beta-oxidation rates. Acts as a low affinity receptor for nicotinic acid. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR; GPCR, family 1

Chromosomal Location of Human Ortholog: 12q24.31

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway
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Product References and Citations for anti-GPR109 antibody

   Nomura H., Int. Immunol. 5:1239-1249(1993).
Ota T., Nat. Genet. 36:40-45(2004).
Wise A., J. Biol. Chem. 278:9869-9874(2003).
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 Research Articles on GPR109    1. Activated HCAR3 signals to MAP kinase cascades via the PLC-dependent PKC and MMP-mediated EGFR pathways
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-GPR109 antibodyDiseases associated with anti-GPR109 antibody
 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Hydroxycarboxylic Acid-binding Receptors Pathway antibodies  Hydroxycarboxylic Acid-binding Receptors Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram
 CAMP Signaling Pathway antibodies  CAMP Signaling Pathway Diagram
 CAMP Signaling Pathway antibodies  CAMP Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Atherosclerosis Antibodies  >7 publications with GPR109 and Atherosclerosis
 Dyslipidemias Antibodies  >6 publications with GPR109 and Dyslipidemias
 Carcinoma, Squamous Cell Antibodies  >3 publications with GPR109 and Carcinoma, Squamous Cell
 Disease Models, Animal Antibodies  >2 publications with GPR109 and Disease Models, Animal
 Fatty Liver Antibodies  >1 publications with GPR109 and Fatty Liver
 Skin Neoplasms Antibodies  >1 publications with GPR109 and Skin Neoplasms
Organs/Tissues associated with anti-GPR109 antibody
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >8 publications with GPR109 and Skin
 Blood Antibodies  >7 publications with GPR109 and Blood
 Lung Antibodies  >2 publications with GPR109 and Lung
 Brain Antibodies  >1 publications with GPR109 and Brain
 Spleen Antibodies  >1 publications with GPR109 and Spleen
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