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anti-GPR120 antibody :: GPR120 Antibody

Scan QR to view Datasheet Catalog #    MBS855267
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GPR120, Antibody

 Also Known As   

GPR120 Antibody

 Product Synonym Names    G-protein coupled receptor 120; G-protein coupled receptor PGR4; G-protein coupled receptor GT01; G-protein coupled receptor 129; GPR129; PGR4
 Product Gene Name   

anti-GPR120 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    607514
 3D Structure    ModBase 3D Structure for Q5NUL3
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 Species Reactivity    Human, Mouse, Rat
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 Specificity    GPR120 antibody detects endogenous levels of total GPR120 protein.
 Purity/Purification    Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Immunogen    The antiserum was produced against synthesized peptide derived from internal of human GPR120.
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 Preparation and Storage    Store at-20 degree C for 1 year.
 Other Notes    Small volumes of anti-GPR120 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-GPR120 antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-GPR120 antibody   

Western Blot (WB), Immunofluorescence (IF), ELISA (EIA)

 Application Notes for anti-GPR120 antibody    WB: 1:500~1:1000
IF: 1:100~1:500
ELISA: 1:1000
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 Testing Data of anti-GPR120 antibody    anti-GPR120 antibody Testing Data image
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 Western Blot (WB) of anti-GPR120 antibody    Peptide-+ Western blot analysis of extracts from LOVO cells, using GPR120 antibody. Immunofluorescence analysis of LOVO cells, using GPR120 antibody.
anti-GPR120 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for GPR120. It may not necessarily be applicable to this product.
 NCBI GI #    307691233
 NCBI GeneID    338557
 NCBI Accession #    NP_001182684.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001195755.1 [Other Products]
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 UniProt Primary Accession #    Q5NUL3 [Other Products]
 UniProt Secondary Accession #    Q495H1; Q5VY25; Q5VY26; Q7Z605; Q86SM7 [Other Products]
 UniProt Related Accession #    Q5NUL3 [Other Products]
 Molecular Weight    40,494 Da
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 NCBI Official Full Name    free fatty acid receptor 4 isoform GPR120-S
 NCBI Official Synonym Full Names    free fatty acid receptor 4
 NCBI Official Symbol    FFAR4 [Similar Products]
 NCBI Official Synonym Symbols   
GT01; PGR4; BMIQ10; GPR120; GPR129; O3FAR1
[Similar Products]
 NCBI Protein Information    free fatty acid receptor 4
 UniProt Protein Name    Free fatty acid receptor 4
 UniProt Synonym Protein Names   
G-protein coupled receptor 120; G-protein coupled receptor 129; G-protein coupled receptor GT01; G-protein coupled receptor PGR4; Omega-3 fatty acid receptor 1
 UniProt Gene Name    FFAR4 [Similar Products]
 UniProt Synonym Gene Names    GPR120; GPR129; O3FAR1; PGR4 [Similar Products]
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 NCBI Summary for GPR120    This gene encodes a G protein-coupled receptor (GPR) which belongs to the rhodopsin family of GPRs. The encoded protein functions as a receptor for free fatty acids, including omega-3, and participates in suppressing anti-inflammatory responses and insulin sensitizing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
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 UniProt Comments for GPR120    Receptor for medium and long-chain free fatty acids (FFAs). Signals via a G(q)/G(11)-coupled pathway. Acts as a receptor for omega-3 fatty acids and mediates robust anti-inflammatory effects, particularly in macrophages and fat cells. The anti-inflammatory effects involve inhibition of TAK1 through a beta-arrestin 2 (ARRB2)/TAB1-dependent effect, but independent of the G(q)/G(11)-coupled pathway. Mediates potent insulin sensitizing and antidiabetic effects by repressing macrophage-induced tissue inflammation. May mediate the taste of fatty acids. Mediates FFA-induced inhibition of apoptosis in enteroendocrine cells. May play a role in the regulation of adipocyte development and differentiation.
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Product References and Citations for anti-GPR120 antibody

   Fredriksson R., FEBS Lett. 554:381-388(2003). Hirasawa A., Nat. Med. 11:90-94(2005). Deloukas P., Nature 429:375-381(2004).
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 Research Articles on GPR120    1. Fatty acids are capable of directly acting on visceral adipocytes to modulate differently TNF-alpha, IL-6, IL-10 and adiponectin expression, with a different and greater effect in morbidly obese subjects. These effects are largely annulled when GPR120 expression was silenced, which suggests that they could be mediated by GPR120.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-GPR120 antibody
 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Free Fatty Acid Receptors Pathway antibodies  Free Fatty Acid Receptors Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Incretin Synthesis, Secretion, And Inactivation Pathway antibodies  Incretin Synthesis, Secretion, And Inactivation Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Peptide Hormone Metabolism Pathway antibodies  Peptide Hormone Metabolism Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram
 Synthesis, Secretion, And Inactivation Of Glucagon-like Peptide-1 (GLP-1) Pathway antibodies  Synthesis, Secretion, And Inactivation Of Glucagon-like Peptide-1 (GLP-1) Pathway Diagram
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