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anti-GR antibody :: Rabbit anti-Human, Mouse GR Antibody

Scan QR to view Datasheet Catalog #    MBS855991
Western Blot
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GR, Antibody

 Also Known As   

GR (Ab-203) Antibody

 Product Synonym Names    GCR; glucocorticoid receptor; GRL; GRL1; NR3C1
 Product Gene Name   

anti-GR antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    138040
 3D Structure    ModBase 3D Structure for P04150
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 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Pathway    Receptors
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 Other Notes    Small volumes of anti-GR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-GR antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-GR antibody   

Western Blot (WB), ELISA (EIA)

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 Western Blot of anti-GR antibody    Western blot analysis of extracts from Jurkat cells, treated with PMA (125ng/ml, 30mins), using GR (Ab-203) antibody.
anti-GR antibody Western Blot (WB) image
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NCBI/Uniprot data below describe general gene information for GR. It may not necessarily be applicable to this product.
 NCBI GI #    4504133
 NCBI GeneID    2908
 NCBI Accession #    NP_000167.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000176.2 [Other Products]
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 UniProt Primary Accession #    P04150 [Other Products]
 UniProt Secondary Accession #    P04151; Q53EP5; Q6N0A4; A0ZXF9; B0LPG8; D3DQF4 [Other Products]
 UniProt Related Accession #    P04150 [Other Products]
 Molecular Weight    82,904 Da
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 NCBI Official Full Name    glucocorticoid receptor isoform alpha
 NCBI Official Synonym Full Names    nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
 NCBI Official Symbol    NR3C1 [Similar Products]
 NCBI Official Synonym Symbols   
GR; GCR; GRL; GCCR; GCRST
[Similar Products]
 NCBI Protein Information    glucocorticoid receptor; glucocorticoid nuclear receptor variant 1
 UniProt Protein Name    Glucocorticoid receptor
 UniProt Synonym Protein Names   
Nuclear receptor subfamily 3 group C member 1
 Protein Family    Grifin
 UniProt Gene Name    NR3C1 [Similar Products]
 UniProt Synonym Gene Names    GRL; GR [Similar Products]
 UniProt Entry Name    GCR_HUMAN
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 NCBI Summary for GR    This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]
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 UniProt Comments for GR    GR: transcription factor of the nuclear receptor family. Receptor for glucocorticoids (GC). Binds to glucocorticoid response elements (GRE) and modulates other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Three alternatively spliced isoforms have been described.

Protein type: DNA-binding; Mitochondrial; Transcription factor; Nuclear receptor

Chromosomal Location of Human Ortholog: 5q31.3

Cellular Component: nucleoplasm; membrane; mitochondrial matrix; cytoplasm; nucleus; cytosol

Molecular Function: protein dimerization activity; glucocorticoid receptor activity; protein binding; zinc ion binding; transcription factor activity; steroid binding

Biological Process: transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent; maternal behavior; adrenal gland development; regulation of glucocorticoid biosynthetic process; chromatin modification; signal transduction; glucocorticoid mediated signaling; glucocorticoid metabolic process; regulation of transcription, DNA-dependent; glucocorticoid receptor signaling pathway; positive regulation of neuron apoptosis; positive regulation of transcription from RNA polymerase II promoter; regulation of gluconeogenesis; gene expression

Disease: Glucocorticoid Resistance, Generalized
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 Research Articles on GR    1. Results suggest that GR may be a potential target for BRCA1 in ovarian cancer progression.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-GR antibodyPathways associated with anti-GR antibody
 Reference Product  PubMed Publications
 JUN antibody  >21 publications with GR and JUN
 STAT3 antibody  >2 publications with GR and STAT3
 NFKB1 antibody  >2 publications with GR and NFKB1
 RELA antibody  >1 publications with GR and RELA
 HSP90AA1 antibody  >1 publications with GR and HSP90AA1
 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 BMAL1:CLOCK,NPAS2 Activates Circadian Gene Expression Pathway antibodies  BMAL1:CLOCK,NPAS2 Activates Circadian Gene Expression Pathway Diagram
 Circadian Clock Pathway antibodies  Circadian Clock Pathway Diagram
 FOXA2 And FOXA3 Transcription Factor Networks Pathway antibodies  FOXA2 And FOXA3 Transcription Factor Networks Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Glucocorticoid Receptor Regulatory Network Pathway antibodies  Glucocorticoid Receptor Regulatory Network Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Nuclear Receptor Transcription Pathway antibodies  Nuclear Receptor Transcription Pathway Diagram
Diseases associated with anti-GR antibodyOrgans/Tissues associated with anti-GR antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >23 publications with GR and Inflammation
 Nervous System Diseases Antibodies  >19 publications with GR and Nervous System Diseases
 Depressive Disorder Antibodies  >19 publications with GR and Depressive Disorder
 Hypertension Antibodies  >18 publications with GR and Hypertension
 Cardiovascular Diseases Antibodies  >16 publications with GR and Cardiovascular Diseases
 Bipolar Disorder Antibodies  >13 publications with GR and Bipolar Disorder
 Necrosis Antibodies  >12 publications with GR and Necrosis
 Lung Diseases, Obstructive Antibodies  >11 publications with GR and Lung Diseases, Obstructive
 Brain Diseases Antibodies  >10 publications with GR and Brain Diseases
 Muscular Diseases Antibodies  >8 publications with GR and Muscular Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >92 publications with GR and Blood
 Brain Antibodies  >78 publications with GR and Brain
 Liver Antibodies  >25 publications with GR and Liver
 Placenta Antibodies  >17 publications with GR and Placenta
 Heart Antibodies  >10 publications with GR and Heart
 Kidney Antibodies  >9 publications with GR and Kidney
 Nerve Antibodies  >9 publications with GR and Nerve
 Adipose Tissue Antibodies  >9 publications with GR and Adipose Tissue
 Connective Tissue Antibodies  >9 publications with GR and Connective Tissue
 Embryonic Tissue Antibodies  >8 publications with GR and Embryonic Tissue
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