NP_000819.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
glutamate receptor 3 isoform 2
NCBI Official Synonym Full Names
glutamate ionotropic receptor AMPA type subunit 3
NCBI Official Synonym Symbols
GLUR3; GLURC; GluA3; MRX94; GLUR-C; GLUR-K3 [Similar Products]
NCBI Protein Information
glutamate receptor 3
UniProt Protein Name
Glutamate receptor 3
UniProt Synonym Protein Names
AMPA-selective glutamate receptor 3; GluR-C; GluR-K3; Glutamate receptor ionotropic, AMPA 3; GluA3
UniProt Synonym Gene Names
NCBI Summary for GRIA3
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing at this locus results in different isoforms, which may vary in their signal transduction properties. [provided by RefSeq, Jul 2008]
UniProt Comments for GRIA3
Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
Research Articles on GRIA3
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Products associated with anti-GRIA3 antibody
Pathways associated with anti-GRIA3 antibody
Diseases associated with anti-GRIA3 antibody
Organs/Tissues associated with anti-GRIA3 antibody
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