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anti-GSK-3b (pY216) antibody :: Rabbit GSK-3b (pY216) Antibody

Scan QR to view Datasheet Catalog #    MBS462202
Testing Data
Unit / Price
0.1 mg  /  $285 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GSK-3b (pY216) (GSK-3b (pY216)), Antibody

★Popular Item★
 Also Known As   

Rabbit anti Phospho- GSK-3beta (pTyr 216)

 Product Synonym Names    Rabbit anti-Phospho-GSK3b (pY216); glycogen synthase kinase 3 beta (GSK3-b)
 Product Gene Name   

anti-GSK-3b (pY216) antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Host    Rabbit
 Species Reactivity    Human, Rat, Mouse, Bovine, Chicken
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 Specificity    This antibody recognizes GSK-3beta (pY216) with a phosphorylated site at Tyrosine 216. It does not crossreact with non-phosphospecific peptide.
 Purity/Purification    The Rabbit IgG is purified by site-modified Epitope Affinity Purification.
 Form/Format    This affinity purified antibody is supplied in sterile Tris-buffered saline (pH7.2) containing antibody stabilizer
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 Antigen Preparation    A synthetic peptide surrounding to the epitope -NVSYI- with a phosphorylation site at Tyr216 of human GSK3-beta protein. This sequence is identical among human, mouse, rat, bovine, dog and chicken species.
 Positive Control    3T3 cell lysate
 Cellular Location    Cytoplasmic
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 Preparation and Storage    The antibodies are stable for 12 months from date of receipt when stored at -20C to -70C. The antibodies can be stored at 2-8C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
 Other Notes    Small volumes of anti-GSK-3b (pY216) antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-GSK-3b (pY216) antibody

   Glycogen Synthase Kinase-3beta (GSK-3beta) is a serine/threonine kinase that affects glycogen metabolism by phosphorylating and down-regulating the activity of muscle glycogen synthase. Growth factor (such as Insulin) binds to its receptor, recruits PKB/AKT kinase to phosphorylate GSK-3beta on Serine 9, which prevents GSK-3beta from phosphorylating glycogen synthase. In contrast, the phosphorylation of tyrosine 216 in the catalytic domain increase this kinase activity to promote cell death under the absence of growth factors. GSK-3beta is also involved in Wnt signaling pathway where it forms a complex with axin, beta-catenin and adenomatous polyposis coli (APC) protein, thus the GSK-3beta inhibitor is considered as a potential approach in Alzheimer's Disease (AD) treatment.
 Applications Tested/Suitable for anti-GSK-3b (pY216) antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-GSK-3b (pY216) antibody    Western Blot: 0.1-1 ug/ml
ELISA: 0.01-0.1 ug/ml
Immunoprecipitation: 2-5 ug/ml

Optimal dilutions should be determined by researchers for the specific applications.
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 Testing Data of anti-GSK-3b (pY216) antibody    anti-GSK-3b (pY216) antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for GSK-3b (pY216). It may not necessarily be applicable to this product.
 NCBI GI #    321461564
 Molecular Weight    46 kDa
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 NCBI Official Full Name    glycogen synthase kinase 3 beta
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Product References and Citations for anti-GSK-3b (pY216) antibody

   Alan P. Kozikowski, et al. Highly Potent and Specific GSK-3beta Inhibitors That Block Tau Phosphorylation and Decrease alpha-Synuclein Protein Expression in a Cellular Model of Parkinson's Disease. ChemMedChem, 2006, 1 (2), 256-266.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-GSK-3b (pY216) antibodyPathways associated with anti-GSK-3b (pY216) antibody
 Reference Product  PubMed Publications
 FLNA antibody  >12 publications with GSK-3b (pY216) and FLNA
 Products by Pathway  Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 Salmonella Infection Pathway antibodies  Salmonella Infection Pathway Diagram
 Salmonella Infection Pathway antibodies  Salmonella Infection Pathway Diagram
Organs/Tissues associated with anti-GSK-3b (pY216) antibody
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >13 publications with GSK-3b (pY216) and Bone
 Connective Tissue Antibodies  >4 publications with GSK-3b (pY216) and Connective Tissue
 Heart Antibodies  >3 publications with GSK-3b (pY216) and Heart
 Muscle Antibodies  >3 publications with GSK-3b (pY216) and Muscle
 Brain Antibodies  >3 publications with GSK-3b (pY216) and Brain
 Vascular Antibodies  >2 publications with GSK-3b (pY216) and Vascular
 Embryonic Tissue Antibodies  >2 publications with GSK-3b (pY216) and Embryonic Tissue
 Ear Antibodies  >1 publications with GSK-3b (pY216) and Ear
 Kidney Antibodies  >1 publications with GSK-3b (pY216) and Kidney
 Umbilical Cord Antibodies  >1 publications with GSK-3b (pY216) and Umbilical Cord
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