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anti-GSK3b (Paired S9) antibody :: Rabbit GSK3b (Paired S9) Antibody

Scan QR to view Datasheet Catalog #    MBS462053
Testing Data
Unit / Price
0.1 mg  /  $265 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GSK3b (Paired S9) (GSK3b (Paired S9)), Antibody

★Popular Item★
 Also Known As   

Rabbit anti GSK-3beta (Paired Ser9), Non-phospho

 Product Synonym Names    Rabbit anti--GSK3b (Paired S9); Glycogen synthase kinase 3 beta (GSK3-b)
 Product Gene Name   

anti-GSK3b (Paired S9) antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 3; NC_000003.11 (119540800..119813264, complement). Location: 3q13.3
 OMIM    605004
 3D Structure    ModBase 3D Structure for P49841
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 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    This antibody recognizes GSK-3beta (Paired Ser9) without phosphorylated site at Serine 9. It does not cross-react with phosphospecific peptides.
 Purity/Purification    The Rabbit IgG is purified by site-modified Epitope Affinity Purification.
 Form/Format    This affinity purified antibody is supplied in sterile Tris-buffered saline (pH7.2) containing antibody stabilizer
 Concentration    Size: 100 ug/200 ul (lot specific)
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 Antigen Preparation    A synthetic peptide surrounding to the epitope -TTSFA- without phosphorylation of human GSK3-beta protein. This sequence is identical among human, mouse, rat, bovine, dog and chicken species
 Positive Control    3T3 cell lysate
 Cellular Location    Cytoplasmic
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 Preparation and Storage    The antibodies are stable for 12 months from date of receipt when stored at -20 degree C to -70 degree C. The antibodies can be stored at 2 degree C-8 degree C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
 Other Notes    Small volumes of anti-GSK3b (Paired S9) antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-GSK3b (Paired S9) antibody

   Glycogen Synthase Kinase-3beta (GSK-3beta) is a serine/threonine kinase that affects glycogen metabolism by phosphorylating and down-regulating the activity of muscle glycogen synthase. Growth factor (such as Insulin) binds to its receptor, recruits PKB/AKT kinase to phsphorylate GSK-3beta on Serine 9, which prevents GSK-3beta from phosphorylating glycogen synthase. In contrast, the phosphorylation of tyrosine 216 in the catalytic domain increase this kinase activity to promote cell death under the absence of growth factors. GSK-3beta is also involved in Wnt signaling pathway where it forms a complex with axin, beta-catenin and adenomatous polyposis coli (APC) protein, thus the GSK-3beta inhibitor is considered as a potential approach in Alzheimer's Disease (AD) treatment.
 Applications Tested/Suitable for anti-GSK3b (Paired S9) antibody   

ELISA, Western Blot, Immunohistochemistry

 Application Notes for anti-GSK3b (Paired S9) antibody    Western Blot: 0.1-1 ug/ml
ELISA: 0.01-0.1 ug/ml
Immunoprecipitation: 2-5 ug/ml
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 Testing Data of anti-GSK3b (Paired S9) antibody    anti-GSK3b (Paired S9) antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for GSK3b (Paired S9). It may not necessarily be applicable to this product.
 NCBI GI #    21361340
 NCBI GeneID    2932
 NCBI Accession #    NP_002084.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_002093.2 [Other Products]
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 UniProt Primary Accession #    P49841 [Other Products]
 UniProt Secondary Accession #    Q9BWH3; Q9UL47; D3DN89 [Other Products]
 UniProt Related Accession #    P49841; Q6FI27 [Other Products]
 Molecular Weight    46 kDa
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 NCBI Official Full Name    glycogen synthase kinase-3 beta isoform 1
 NCBI Official Synonym Full Names    glycogen synthase kinase 3 beta
 NCBI Official Symbol    GSK3B [Similar Products]
 NCBI Official Synonym Symbols   
GSK3B
[Similar Products]
 NCBI Protein Information    glycogen synthase kinase-3 beta; GSK-3 beta; GSK3beta isoform; OTTHUMP00000165239; OTTHUMP00000165240
 UniProt Protein Name    Glycogen synthase kinase-3 beta
 UniProt Gene Name    GSK3B [Similar Products]
 UniProt Entry Name    GSK3B_HUMAN
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 NCBI Summary for GSK3b (Paired S9)    The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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 UniProt Comments for GSK3b (Paired S9)    Function: Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin. Phosphorylates CTNNB1/beta-catenin. Phosphorylates SNAI1. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Phosphorylates MACF1 and this phosphorylation inhibits the binding of MACF1 to microtubules which is critical for its role in bulge stem cell migration and skin wound repair. May be required for early embryo development and neuron differentiation

By similarity. Ref.7 Ref.11 Ref.30 Ref.34

Catalytic activity: ATP + [tau protein] = ADP + [tau protein] phosphate.

Enzyme regulation: Activated by phosphorylation at Tyr-216. Inhibited when phosphorylated by AKT1. Ref.34

Subunit structure: Monomer

By similarity. Interacts with ARRB2 and DISC1

By similarity. Interacts with CABYR, MMP2, MUC1, NIN and PRUNE Interacts with AXIN1; the interaction mediates hyperphosphorylates of CTNNB1 leading to its ubiquitination and destruction. Interacts with and phosphorylates SNAI1. Interacts with DNM1L (via a C-terminal domain). Found in a complex composed of MACF1, APC, AXIN1, CTNNB1 and GSK3B

By similarity. Ref.6 Ref.7 Ref.9 Ref.10 Ref.11 Ref.13 Ref.18 Ref.20 Ref.27 Ref.34

Subcellular location: Cytoplasm. Nucleus. Cell membrane. Note: The phosphorylated form shows localization to cytoplasm and cell membrane. The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosophorylated form to the cell membrane. Ref.11 Ref.30

Tissue specificity: Expressed in testis, thymus, prostate and ovary and weakly expressed in lung, brain and kidney.

Post-translational modification: Phosphorylated by AKT1 and ILK1. Activated by phosphorylation at Tyr-216. Ref.9 Ref.12 Ref.14 Ref.15 Ref.16 Ref.17 Ref.19 Ref.21 Ref.22 Ref.23 Ref.24 Ref.25 Ref.26 Ref.28 Ref.29 Ref.30 Ref.34

Sequence similarities: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.Contains 1 protein kinase domain.
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Product References and Citations for anti-GSK3b (Paired S9) antibody

   Alan P. Kozikowski, et al. Highly Potent and Specific GSK-3beta Inhibitors That Block Tau Phosphorylation and Decrease alpha- Synuclein Protein Expression in a Cellular Model of Parkinson's Disease. ChemMedChem, 2006, 1 (2), 256-266.
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 Research Articles on GSK3b (Paired S9)    1. The haplotype analysis of this study revealed that, the T-T haplotype of both GSK3beta polymorphisms was over-represented in parkinson disease patients compared to controls, and this association was independent of MAPT H1 haplotype.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-GSK3b (Paired S9) antibodyPathways associated with anti-GSK3b (Paired S9) antibody
 Reference Product  PubMed Publications
 CTNNB1 antibody  >18 publications with GSK3b (Paired S9) and CTNNB1
 AKT1 antibody  >8 publications with GSK3b (Paired S9) and AKT1
 MAPT antibody  >7 publications with GSK3b (Paired S9) and MAPT
 APP antibody  >5 publications with GSK3b (Paired S9) and APP
 APC antibody  >4 publications with GSK3b (Paired S9) and APC
 MYC antibody  >4 publications with GSK3b (Paired S9) and MYC
 AXIN1 antibody  >3 publications with GSK3b (Paired S9) and AXIN1
 PSEN1 antibody  >3 publications with GSK3b (Paired S9) and PSEN1
 AXIN2 antibody  >2 publications with GSK3b (Paired S9) and AXIN2
 AKT2 antibody  >2 publications with GSK3b (Paired S9) and AKT2
 Products by Pathway  Pathway Diagram
 AKT Phosphorylates Targets In The Cytosol Pathway antibodies  AKT Phosphorylates Targets In The Cytosol Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Aurora A Signaling Pathway antibodies  Aurora A Signaling Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
Diseases associated with anti-GSK3b (Paired S9) antibodyOrgans/Tissues associated with anti-GSK3b (Paired S9) antibody
 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >18 publications with GSK3b (Paired S9) and Mental Disorders
 Neurodegenerative Diseases Antibodies  >11 publications with GSK3b (Paired S9) and Neurodegenerative Diseases
 Neoplasms Antibodies  >11 publications with GSK3b (Paired S9) and Neoplasms
 Dementia Antibodies  >9 publications with GSK3b (Paired S9) and Dementia
 Alzheimer Disease Antibodies  >8 publications with GSK3b (Paired S9) and Alzheimer Disease
 Bipolar Disorder Antibodies  >7 publications with GSK3b (Paired S9) and Bipolar Disorder
 Insulin Resistance Antibodies  >7 publications with GSK3b (Paired S9) and Insulin Resistance
 Mood Disorders Antibodies  >6 publications with GSK3b (Paired S9) and Mood Disorders
 Metabolic Diseases Antibodies  >6 publications with GSK3b (Paired S9) and Metabolic Diseases
 Depressive Disorder Antibodies  >5 publications with GSK3b (Paired S9) and Depressive Disorder
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >17 publications with GSK3b (Paired S9) and Brain
 Blood Antibodies  >10 publications with GSK3b (Paired S9) and Blood
 Ovary Antibodies  >8 publications with GSK3b (Paired S9) and Ovary
 Muscle Antibodies  >4 publications with GSK3b (Paired S9) and Muscle
 Bone Antibodies  >3 publications with GSK3b (Paired S9) and Bone
 Heart Antibodies  >3 publications with GSK3b (Paired S9) and Heart
 Liver Antibodies  >3 publications with GSK3b (Paired S9) and Liver
 Uterus Antibodies  >2 publications with GSK3b (Paired S9) and Uterus
 Pancreas Antibodies  >2 publications with GSK3b (Paired S9) and Pancreas
 Connective Tissue Antibodies  >2 publications with GSK3b (Paired S9) and Connective Tissue
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