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anti-GSK3beta antibody :: GSK3beta Antibody

Scan QR to view Datasheet Catalog #    MBS857417
Testing Data
Unit / Price
0.05 mg  /  $180 +1 FREE 8GB USB
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

GSK3beta, Antibody

 Also Known As   

GSK3beta (Ab-216) Antibody

 Product Gene Name   

anti-GSK3beta antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    605004
 3D Structure    ModBase 3D Structure for P49841
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 Species Reactivity    Human, Mouse, Rat
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 Specificity    GSK3beta (Ab-216) antibody detects endogenous levels of total GSK3beta.
 Purity/Purification    Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatogramphy using non-phosphopeptide corresponding to the phosphorylation site.
 Form/Format    In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Immunogen    The antiserum was produced against synthesized non-phosphopeptide derived from human GSK3beta around the phosphorylation site of tyrosine 216 (V-S-YP-I-C).
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 Preparation and Storage    Store at-20 degree C for 1 year
 Other Notes    Small volumes of anti-GSK3beta antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-GSK3beta antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-GSK3beta antibody   

Western Blot (WB)

 Application Notes for anti-GSK3beta antibody    WB: 1:500-1:1000
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 Testing Data of anti-GSK3beta antibody    Western blot analysis of extract from 293 cells, untreated or treated with insulin (40uM, 30min), using GSK3beta (Ab-216) antibody and GSK3beta (Phospho-Tyr216) Antibody (E011301, Lane 3 and 4).
anti-GSK3beta antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for GSK3beta. It may not necessarily be applicable to this product.
 NCBI GI #    225903437
 NCBI GeneID    2932
 NCBI Accession #    NP_001139628.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001146156.1 [Other Products]
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 UniProt Primary Accession #    P49841 [Other Products]
 UniProt Secondary Accession #    Q9BWH3; Q9UL47; D3DN89 [Other Products]
 UniProt Related Accession #    P49841 [Other Products]
 Molecular Weight    48,034 Da
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 NCBI Official Full Name    glycogen synthase kinase-3 beta isoform 2
 NCBI Official Synonym Full Names    glycogen synthase kinase 3 beta
 NCBI Official Symbol    GSK3B [Similar Products]
 NCBI Protein Information    glycogen synthase kinase-3 beta
 UniProt Protein Name    Glycogen synthase kinase-3 beta
 UniProt Synonym Protein Names   
Serine/threonine-protein kinase GSK3B (EC:2.7.11.1)
 UniProt Gene Name    GSK3B [Similar Products]
 UniProt Synonym Gene Names    GSK-3 beta [Similar Products]
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 NCBI Summary for GSK3beta    The protein encoded by this gene is a serine-threonine kinase belonging to the glycogen synthase kinase subfamily. It is a negative regulator of glucose homeostasis and is involved in energy metabolism, inflammation, ER-stress, mitochondrial dysfunction, and apoptotic pathways. Defects in this gene have been associated with Parkinson disease and Alzheimer disease. [provided by RefSeq, Aug 2017]
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 UniProt Comments for GSK3beta    Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. May also mediate the development of insulin resistance by regulating activation of transcription factors. Regulates protein synthesis by controlling the activity of initiation factor 2B (EIF2BE/EIF2B5) in the same manner as glycogen synthase. In Wnt signaling, GSK3B forms a multimeric complex with APC, AXIN1 and CTNNB1/beta-catenin and phosphorylates the N-terminus of CTNNB1 leading to its degradation mediated by ubiquitin/proteasomes. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates NFATC1/NFATC on conserved serine residues promoting NFATC1/NFATC nuclear export, shutting off NFATC1/NFATC gene regulation, and thereby opposing the action of calcineurin. Phosphorylates MAPT/TAU on 'Thr-548', decreasing significantly MAPT/TAU ability to bind and stabilize microtubules. MAPT/TAU is the principal component of neurofibrillary tangles in Alzheimer disease. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Phosphorylates MACF1, inhibiting its binding to microtubules which is critical for its role in bulge stem cell migration and skin wound repair. Probably regulates NF-kappa-B (NFKB1) at the transcriptional level and is required for the NF-kappa-B-mediated anti-apoptotic response to TNF-alpha (TNF/TNFA). Negatively regulates replication in pancreatic beta-cells, resulting in apoptosis, loss of beta-cells and diabetes. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation. Phosphorylates MUC1 in breast cancer cells, decreasing the interaction of MUC1 with CTNNB1/beta-catenin. Is necessary for the establishment of neuronal polarity and axon outgrowth. Phosphorylates MARK2, leading to inhibit its activity. Phosphorylates SIK1 at 'Thr-182', leading to sustain its activity. Phosphorylates ZC3HAV1 which enhances its antiviral activity. Phosphorylates SNAI1, leading to its BTRC-triggered ubiquitination and proteasomal degradation. Phosphorylates SFPQ at 'Thr-687' upon T-cell activation. Phosphorylates NR1D1 st 'Ser-55' and 'Ser-59' and stabilizes it by protecting it from proteasomal degradation. Regulates the circadian clock via phosphorylation of the major clock components including ARNTL/BMAL1, CLOCK and PER2. Phosphorylates CLOCK AT 'Ser-427' and targets it for proteasomal degradation. Phosphorylates ARNTL/BMAL1 at 'Ser-17' and 'Ser-21' and primes it for ubiquitination and proteasomal degradation. Phosphorylates OGT at 'Ser-3' or 'Ser-4' which positively regulates its activity. Phosphorylates MYCN in neuroblastoma cells which may promote its degradation (PubMed:24391509).
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Product References and Citations for anti-GSK3beta antibody

   Chin PC, et al. Brain Res Mol Brain Res 2005 Jun 13; 137(1-2): 193-201 Takahashi-Yanaga F, et al. Biochem Biophys Res Commun 2004 Apr 02; 316(2): 411-415 Fan G, et al. J Biol Chem 2003 Dec 26; 278(52): 52432-52436 Liao X, et al. Mol Cancer Ther 2003 Nov; 2(11): 1215-1222.
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 Research Articles on GSK3beta    1. In conclusion, the authors demonstrated that AKT activation prevents apoptosis, partly through inhibition of GSK3beta, resulting in pluripotent stem cells survival.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-GSK3beta antibodyPathways associated with anti-GSK3beta antibody
 Reference Product  PubMed Publications
 CTNNB1 antibody  >20 publications with GSK3beta and CTNNB1
 MAPT antibody  >8 publications with GSK3beta and MAPT
 AKT1 antibody  >8 publications with GSK3beta and AKT1
 APP antibody  >6 publications with GSK3beta and APP
 APC antibody  >4 publications with GSK3beta and APC
 MYC antibody  >4 publications with GSK3beta and MYC
 AXIN1 antibody  >3 publications with GSK3beta and AXIN1
 PSEN1 antibody  >3 publications with GSK3beta and PSEN1
 AXIN2 antibody  >2 publications with GSK3beta and AXIN2
 AKT2 antibody  >2 publications with GSK3beta and AKT2
 Products by Pathway  Pathway Diagram
 AKT Phosphorylates Targets In The Cytosol Pathway antibodies  AKT Phosphorylates Targets In The Cytosol Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Aurora A Signaling Pathway antibodies  Aurora A Signaling Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
Diseases associated with anti-GSK3beta antibodyOrgans/Tissues associated with anti-GSK3beta antibody
 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >19 publications with GSK3beta and Brain Diseases
 Nervous System Diseases Antibodies  >19 publications with GSK3beta and Nervous System Diseases
 Neoplasms Antibodies  >18 publications with GSK3beta and Neoplasms
 Bipolar Disorder Antibodies  >11 publications with GSK3beta and Bipolar Disorder
 Alzheimer Disease Antibodies  >11 publications with GSK3beta and Alzheimer Disease
 Disease Models, Animal Antibodies  >8 publications with GSK3beta and Disease Models, Animal
 Schizophrenia Antibodies  >7 publications with GSK3beta and Schizophrenia
 Depressive Disorder Antibodies  >7 publications with GSK3beta and Depressive Disorder
 Movement Disorders Antibodies  >6 publications with GSK3beta and Movement Disorders
 Cardiovascular Diseases Antibodies  >5 publications with GSK3beta and Cardiovascular Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >29 publications with GSK3beta and Brain
 Blood Antibodies  >14 publications with GSK3beta and Blood
 Ovary Antibodies  >10 publications with GSK3beta and Ovary
 Muscle Antibodies  >9 publications with GSK3beta and Muscle
 Bone Antibodies  >5 publications with GSK3beta and Bone
 Heart Antibodies  >4 publications with GSK3beta and Heart
 Liver Antibodies  >4 publications with GSK3beta and Liver
 Lung Antibodies  >4 publications with GSK3beta and Lung
 Embryonic Tissue Antibodies  >3 publications with GSK3beta and Embryonic Tissue
 Pancreas Antibodies  >2 publications with GSK3beta and Pancreas
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