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anti-GCG antibody :: Rabbit Glucagon Antibody

Scan QR to view Datasheet Catalog #    MBS852380
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Glucagon (GCG), Antibody

★Popular Item★
 Also Known As   

Glucagon Antibody

 Product Synonym Names    Glicentin; Glicentin-related polypeptide; Oxyntomodulin; Glucagon-like peptide 1(GLP-1); Glucagon-like peptide 1(7-37); Glucagon-like peptide 1(7-36); Glucagon-like peptide 2(GLP-2)
 Product Gene Name   

anti-GCG antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    138030
 3D Structure    ModBase 3D Structure for P01275
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 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    Glucagon antibody detects endogenous levels of total glucagon protein.
 Purity/Purification    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
 Concentration    100ug/100ul (lot specific)
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 Immunogen    The antiserum was produced against synthesized peptide derived from human glucagon.
 Pathway    Growth Factors
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 Preparation and Storage    Store at -20 degree C for 1 year
 Other Notes    Small volumes of anti-GCG antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-GCG antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-GCG antibody   

Western Blot (WB), Immunofluorescence (IF), ELISA (EIA)

 Application Notes for anti-GCG antibody    WB: 1:500~1:1000, IF: 1:100~1:500, ELISA: 1:5000
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 Testing Data of anti-GCG antibody    anti-GCG antibody Testing Data image
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 Testing Data #2 of anti-GCG antibody    Peptide - +
Western blot analysis of extracts from COS7 cells, using Glucagon antibody (E11-0206C).
Immunofluorescence analysis of NIH/3T3 cells, using Glucagon antibody (E11-0206C).
anti-GCG antibody Testing Data #2 image
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NCBI/Uniprot data below describe general gene information for GCG. It may not necessarily be applicable to this product.
 NCBI GI #    4503945
 NCBI GeneID    2641
 NCBI Accession #    NP_002045.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002054.4 [Other Products]
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 UniProt Primary Accession #    P01275 [Other Products]
 UniProt Secondary Accession #    Q53TP6; A6NN65 [Other Products]
 UniProt Related Accession #    P01275 [Other Products]
 Molecular Weight    20,909 Da [Similar Products]
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 NCBI Official Full Name    glucagon preproprotein
 NCBI Official Synonym Full Names    glucagon
 NCBI Official Symbol    GCG [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    glucagon; preproglucagon; glucagon-like peptide 1; glucagon-like peptide 2; glicentin-related polypeptide
 UniProt Protein Name    Glucagon
 UniProt Synonym Protein Names   
Incretin hormone
 Protein Family    Glucagon
 UniProt Gene Name    GCG [Similar Products]
 UniProt Synonym Gene Names    GRPP; OXM; OXY; GLP-1; GLP-1(7-37); GLP-1(7-36); GLP-2 [Similar Products]
 UniProt Entry Name    GLUC_HUMAN
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 NCBI Summary for GCG    The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon. [provided by RefSeq, Jul 2008]
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 UniProt Comments for GCG    GCG: Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes. Glucagon release is stimulated by hypoglycemia and inhibited by hyperglycemia, insulin, and somatostatin. GLP-1 and GLP-2 are induced in response to nutrient ingestion. Glucagon is secreted in the A cells of the islets of Langerhans. GLP-1, GLP-2, oxyntomodulin and glicentin are secreted from enteroendocrine cells throughout the gastrointestinal tract. GLP1 and GLP2 are also secreted in selected neurons in the brain. Belongs to the glucagon family.

Protein type: Secreted; Secreted, signal peptide; Hormone

Chromosomal Location of Human Ortholog: 2q36-q37

Cellular Component: extracellular space; endoplasmic reticulum lumen; plasma membrane; extracellular region

Molecular Function: identical protein binding; protein binding; hormone activity; glucagon receptor binding; receptor binding

Biological Process: positive regulation of protein binding; positive regulation of histone H3-K4 methylation; signal transduction; positive regulation of peptidyl-serine phosphorylation; response to starvation; G-protein signaling, coupled to cAMP nucleotide second messenger; G-protein coupled receptor protein signaling pathway; cell proliferation; cellular protein metabolic process; positive regulation of protein kinase activity; positive regulation of cAMP biosynthetic process; energy reserve metabolic process; feeding behavior; regulation of insulin secretion; negative regulation of apoptosis
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Product References and Citations for anti-GCG antibody

   Edoardo C. Aromataris, J. Physiol., Jun 2006; 573: 611 - 625.
Xiao C. Li, Hypertension, Mar 2006; 47: 580 - 585.
Kirstan A. Vessey, Invest. Ophthalmol. Vis. Sci., Nov 2005; 46: 3922 - 3931.
Xiaosong Ma, Mol. Endocrinol., Jan 2005; 19: 198 - 212.
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 Research Articles on GCG    1. GS and HG might regulate different pathways of GLP-1 production in diabetes
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-GCG antibodyPathways associated with anti-GCG antibody
 Reference Product  PubMed Publications
 INS antibody  >13 publications with GCG and INS
 GLP1R antibody  >7 publications with GCG and GLP1R
 SST antibody  >5 publications with GCG and SST
 GCGR antibody  >5 publications with GCG and GCGR
 GIPR antibody  >2 publications with GCG and GIPR
 SCT antibody  >2 publications with GCG and SCT
 FOXA2 antibody  >2 publications with GCG and FOXA2
 Products by Pathway  Pathway Diagram
 Class B/2 (Secretin Family Receptors) Pathway antibodies  Class B/2 (Secretin Family Receptors) Pathway Diagram
 FOXA1 Transcription Factor Network Pathway antibodies  FOXA1 Transcription Factor Network Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies  Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
 Glucagon Signaling In Metabolic Regulation Pathway antibodies  Glucagon Signaling In Metabolic Regulation Pathway Diagram
 Glucagon-like Peptide-1 (GLP1) Regulates Insulin Secretion Pathway antibodies  Glucagon-like Peptide-1 (GLP1) Regulates Insulin Secretion Pathway Diagram
 Glucagon-type Ligand Receptors Pathway antibodies  Glucagon-type Ligand Receptors Pathway Diagram
Diseases associated with anti-GCG antibodyOrgans/Tissues associated with anti-GCG antibody
 Disease Name  Pubmed Publications
 Muscular Diseases Antibodies  >72 publications with GCG and Muscular Diseases
 Diabetes Mellitus, Type 2 Antibodies  >25 publications with GCG and Diabetes Mellitus, Type 2
 Obesity Antibodies  >16 publications with GCG and Obesity
 Vascular Diseases Antibodies  >15 publications with GCG and Vascular Diseases
 Insulin Resistance Antibodies  >12 publications with GCG and Insulin Resistance
 Hyperglycemia Antibodies  >11 publications with GCG and Hyperglycemia
 Kidney Diseases Antibodies  >11 publications with GCG and Kidney Diseases
 Hyperinsulinism Antibodies  >9 publications with GCG and Hyperinsulinism
 Heart Diseases Antibodies  >8 publications with GCG and Heart Diseases
 Liver Diseases Antibodies  >7 publications with GCG and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Pancreas Antibodies  >37 publications with GCG and Pancreas
 Liver Antibodies  >19 publications with GCG and Liver
 Intestine Antibodies  >18 publications with GCG and Intestine
 Connective Tissue Antibodies  >13 publications with GCG and Connective Tissue
 Stomach Antibodies  >7 publications with GCG and Stomach
 Embryonic Tissue Antibodies  >6 publications with GCG and Embryonic Tissue
 Uterus Antibodies  >1 publications with GCG and Uterus
 Uncharacterized Tissue Antibodies  >1 publications with GCG and Uncharacterized Tissue
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