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anti-GARS antibody :: Mouse anti-Human Glycyl-TRNA Synthetase Antibody

Scan QR to view Datasheet Catalog #    MBS140491 anti-GARS antibody
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.02 mg  /  $205 +1 FREE 8GB USB
0.1 mg  /  $505 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Glycyl-TRNA Synthetase (GARS), Antibody

★Popular Item★
 Also Known As   

Mouse Anti Human Glycyl-TRNA Synthetase

 Product Synonym Names    GARS Antibody; Glycyl-TRNA Synthetase, Mouse Anti Human; Glycine--tRNA ligase; Diadenosine tetraphosphate synthetase; AP-4-A synthetase; Glycyl-tRNA synthetase; GlyRS; GARS; CMT2D; DSMAV; HMN5; SMAD1
 Product Gene Name   

anti-GARS antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    600287
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 Isotype    Mouse IgG1 heavy chain and k light chain.
 Clone Number    PAT4E10AT
 Host    Mouse
 Species Reactivity    Human
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 Purity/Purification    GARS antibody was purified from mouse ascitic fluids by protein -A affinity chromatography.
 Form/Format    1mg/ml containing PBS, pH-7.4, 10% Glycerol and 0.02% Sodium Azide.
Sterile filtered colorless solution.
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 Type    Mouse Anti Human Monoclonal
 Immunogen    Anti-human GARS mAb, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human GARS amino acids 43-289 purified from E Coli.
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 Preparation and Storage    Storage: For periods up to 1 month store at 4C, for longer periods of time, store at -20C.

Prevent freeze thaw cycles.

Stability: 12 months at -20C. 1 month at 4C.
 Other Notes    Small volumes of anti-GARS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-GARS antibody

   GARS is an (alpha)2 dimer which is a member of the class II family of tRNA synthetases. GARS is a glycyl-tRNA synthetase, one of the aminoacyl-tRNA synthetases which charge tRNAs with their cognate amino acids. GARS catalyzes the attachment of glycine to tRNA(Gly). In addition, GARS is able to produce diadenosine tetraphosphate (Ap4A), which is a universal pleiotropic signaling molecule required for cell regulation pathways, by direct condensation of two ATPs. GARS has been demonstrated to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis.
 Product Categories/Family for anti-GARS antibody    MONOCLONAL ANTIBODIES; ANTI-HUMAN ENZYMES
 Applications Tested/Suitable for anti-GARS antibody   

GARS antibody has been tested by ELISA, Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.

 Application Notes for anti-GARS antibody    Recommended starting dilution is 1:500
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NCBI/Uniprot data below describe general gene information for GARS. It may not necessarily be applicable to this product.
 NCBI GI #    1311463
 NCBI GeneID    2617
 NCBI Accession #    BAA06338.1 [Other Products]
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 UniProt Secondary Accession #    Q969Y1; B3KQA2; B4DIA0 [Other Products]
 UniProt Related Accession #    P41250 [Other Products]
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 NCBI Official Full Name    glycyl tRNA synthetase
 NCBI Official Synonym Full Names    glycyl-tRNA synthetase
 NCBI Official Symbol    GARS [Similar Products]
 NCBI Official Synonym Symbols   
HMN5; CMT2D; DSMAV; GlyRS; SMAD1
[Similar Products]
 NCBI Protein Information    glycine--tRNA ligase
 UniProt Protein Name    Glycine--tRNA ligase
 UniProt Synonym Protein Names   
Diadenosine tetraphosphate synthetase; AP-4-A synthetase; Glycyl-tRNA synthetase; GlyRS
 Protein Family    Glycine--tRNA ligase
 UniProt Gene Name    GARS [Similar Products]
 UniProt Synonym Gene Names    AP-4-A synthetase; GlyRS [Similar Products]
 UniProt Entry Name    SYG_HUMAN
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 UniProt Comments for GARS    GARS: Catalyzes the attachment of glycine to tRNA(Gly). Is also able produce diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Defects in GARS are the cause of Charcot-Marie-Tooth disease type 2D (CMT2D). CMT2D is a form of Charcot- Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathy or CMT1, and primary peripheral axonal neuropathy or CMT2. Neuropathies of the CMT2 group are characterized by signs of axonal regeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. CMT2D is characterized by a more severe phenotype in the upper extremities (severe weakness and atrophy, absence of tendon reflexes) than in the lower limbs. CMT2D inheritance is autosomal dominant. Defects in GARS are a cause of distal hereditary motor neuronopathy type 5A (HMN5A); also known as distal hereditary motor neuropathy type V (DSMAV). A disorder characterized by distal muscular atrophy mainly affecting the upper extremities, in contrast to other distal motor neuronopathies. These constitute a heterogeneous group of neuromuscular diseases caused by selective degeneration of motor neurons in the anterior horn of the spinal cord, without sensory deficit in the posterior horn. The overall clinical picture consists of a classical distal muscular atrophy syndrome in the legs without clinical sensory loss. The disease starts with weakness and wasting of distal muscles of the anterior tibial and peroneal compartments of the legs. Later on, weakness and atrophy may expand to the proximal muscles of the lower limbs and/or to the distal upper limbs. Belongs to the class-II aminoacyl-tRNA synthetase family.

Protein type: EC 6.1.1.14; Ligase; Mitochondrial; Translation

Chromosomal Location of Human Ortholog: 7p15

Cellular Component: axon; cytoplasm; cytosol; mitochondrial matrix; nucleoplasm

Molecular Function: bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity; glycine-tRNA ligase activity; protein dimerization activity

Biological Process: diadenosine tetraphosphate biosynthetic process; glycyl-tRNA aminoacylation; tRNA aminoacylation for protein translation

Disease: Charcot-marie-tooth Disease, Axonal, Type 2d; Neuronopathy, Distal Hereditary Motor, Type Va
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-GARS antibodyPathways associated with anti-GARS antibody
 Reference Product  PubMed Publications
 AARS antibody  >4 publications with GARS and AARS
 IARS antibody  >1 publications with GARS and IARS
 Products by Pathway  Pathway Diagram
 Aminoacyl-tRNA Biosynthesis Pathway antibodies  Aminoacyl-tRNA Biosynthesis Pathway Diagram
 Aminoacyl-tRNA Biosynthesis Pathway antibodies  Aminoacyl-tRNA Biosynthesis Pathway Diagram
 Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway antibodies  Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway Diagram
 Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway antibodies  Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway Diagram
 Cytosolic TRNA Aminoacylation Pathway antibodies  Cytosolic TRNA Aminoacylation Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Mitochondrial TRNA Aminoacylation Pathway antibodies  Mitochondrial TRNA Aminoacylation Pathway Diagram
 TRNA Aminoacylation Pathway antibodies  TRNA Aminoacylation Pathway Diagram
Diseases associated with anti-GARS antibodyOrgans/Tissues associated with anti-GARS antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >146 publications with GARS and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >38 publications with GARS and Cardiovascular Diseases
 Pain Antibodies  >23 publications with GARS and Pain
 Disease Models, Animal Antibodies  >12 publications with GARS and Disease Models, Animal
 Carcinoma Antibodies  >6 publications with GARS and Carcinoma
 Inflammation Antibodies  >5 publications with GARS and Inflammation
 Cognition Disorders Antibodies  >5 publications with GARS and Cognition Disorders
 Charcot-Marie-Tooth disease, Type 2D Antibodies  >5 publications with GARS and Charcot-Marie-Tooth disease, Type 2D
 Liver Diseases Antibodies  >4 publications with GARS and Liver Diseases
 Thrombosis Antibodies  >4 publications with GARS and Thrombosis
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >78 publications with GARS and Brain
 Bone Antibodies  >45 publications with GARS and Bone
 Nerve Antibodies  >41 publications with GARS and Nerve
 Blood Antibodies  >40 publications with GARS and Blood
 Vascular Antibodies  >40 publications with GARS and Vascular
 Muscle Antibodies  >25 publications with GARS and Muscle
 Eye Antibodies  >12 publications with GARS and Eye
 Liver Antibodies  >6 publications with GARS and Liver
 Ovary Antibodies  >6 publications with GARS and Ovary
 Heart Antibodies  >6 publications with GARS and Heart
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