NP_004122.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
granzyme B isoform 1 preproprotein
NCBI Official Synonym Full Names
granzyme B
NCBI Official Synonym Symbols
C11; HLP; CCPI; CGL1; CSPB; SECT; CGL-1; CSP-B; CTLA1; CTSGL1 [Similar Products]
NCBI Protein Information
granzyme B
UniProt Protein Name
Granzyme B
UniProt Synonym Protein Names
C11; CTLA-1; Cathepsin G-like 1; CTSGL1; Cytotoxic T-lymphocyte proteinase 2; Lymphocyte protease; Fragmentin-2; Granzyme-2; Human lymphocyte protein; HLP; SECT; T-cell serine protease 1-3E
UniProt Synonym Gene Names
NCBI Summary for GZMB
This gene encodes a member of the granzyme subfamily of proteins, part of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) and proteolytically processed to generate the active protease, which induces target cell apoptosis. This protein also processes cytokines and degrades extracellular matrix proteins, and these roles are implicated in chronic inflammation and wound healing. Expression of this gene may be elevated in human patients with cardiac fibrosis. [provided by RefSeq, Sep 2016]
UniProt Comments for GZMB
This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.
Product References and Citations for anti-GZMB antibody
David A. Jans, J. Biol. Chem., Nov 1996; 271: 30781. Eugene Estella, Diabetes, Aug 2006; 55: 2212-2219. Yong Gu, J. Biol. Chem., May 1996; 271: 10816. Jiuru Sun, J. Biol. Chem., Nov 1996; 271: 27802.
Research Articles on GZMB
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Products associated with anti-GZMB antibody
Pathways associated with anti-GZMB antibody
Diseases associated with anti-GZMB antibody
Organs/Tissues associated with anti-GZMB antibody
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