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anti-H3R26me2a antibody :: Rabbit H3R26me2a Antibody

Scan QR to view Datasheet Catalog #    MBS126193
Unit / Price
0.05 mL  /  $265 +1 FREE 8GB USB
0.1 mL  /  $380 +1 FREE 8GB USB
0.2 mL  /  $555 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

H3R26me2a, Antibody

★Popular Item★
 Also Known As   

Histone H3R26me2a Polyclonal Antibody

 Product Synonym Names    Asymmetric DiMethyl-Histone H3-R26: HIST1H3J; H3/j; H3FJ; Histone H3.1; Histone H3/a; Histone H3/b; Histone H3/c; Histone H3/d; Histone H3/f; Histone H3/h; Histone H3/I; Histone H3/j; Histone H3/k; Histone H3/l
 Product Gene Name   

anti-H3R26me2a antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 602819
 3D Structure    ModBase 3D Structure for P68431
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 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat, Other (Wide Range)
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 Purity/Purification    Affinity Purification
 Concentration    1mg/ml (lot specific)
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 Species    Human
 Route    Synthetic Peptide
 Immunogen    A synthetic methylated peptide corresponding to residues surrounding Arg26 of human histone H3
 Calculated Molecular Weight    15kDa
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 Preparation and Storage    Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Other Notes    Small volumes of anti-H3R26me2a antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-H3R26me2a antibody

   Modulation of chromatin structure plays an important role in the regulation of transcription in eukaryotes. The nucleosome, made up of DNA wound around eight core histone proteins (two each of H2A, H2B, H3, and H4), is the primary building block of chromatin (1). The amino-terminal tails of core histones undergo various post-translational modifications, including acetylation, phosphorylation, methylation, and ubiquitination (2-5). These modifications occur in response to various stimuli and have a direct effect on the accessibility of chromatin to transcription factors and, therefore, gene expression (6). In most species, histone H2B is primarily acetylated at Lys5, 12, 15, and 20 (4,7). Histone H3 is primarily acetylated at Lys9, 14, 18, 23, 27, and 56. Acetylation of H3 at Lys9 appears to have a dominant role in histone deposition and chromatin assembly in some organisms (2,3). Phosphorylation at Ser10, Ser28, and Thr11 of histone H3 is tightly correlated with chromosome condensation during both mitosis and meiosis (8-10). Phosphorylation at Thr3 of histone H3 is highly conserved among many species and is catalyzed by the kinase haspin. Immunostaining with phospho-specific antibodies in mammalian cells reveals mitotic phosphorylation at Thr3 of H3 in prophase and its dephosphorylation during anaphase (11).
 Product Categories/Family for anti-H3R26me2a antibody    Methylation
 Applications Tested/Suitable for anti-H3R26me2a antibody   

Western Blot (WB), Immunoprecipitation (IP)

 Application Notes for anti-H3R26me2a antibody    WB: 1:500 - 1:2000
IF: 1:50 - 1:200
IP: 1:50 - 1:200
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 Western Blot (WB) of anti-H3R26me2a antibody    Western blot analysis of extracts of various cell lines, using Asymmetric DiMethyl-Histone H3-R26 antibody.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
anti-H3R26me2a antibody Western Blot (WB) (WB) image
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 Immunofluorescence (IF) of anti-H3R26me2a antibody    Immunofluorescence analysis of 293T cells using Asymmetric DiMethyl-Histone H3-R26 antibody. Blue: DAPI for nuclear staining.
anti-H3R26me2a antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for H3R26me2a. It may not necessarily be applicable to this product.
 NCBI GI #    55977055
 NCBI GeneID    8356
 NCBI Accession #    P68431.2 [Other Products]
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 UniProt Primary Accession #    P68431 [Other Products]
 UniProt Secondary Accession #    P02295; P02296; P16106; Q6ISV8; Q6NWP8; Q6NWP9; Q6NXU4; Q71DJ3; Q93081; A0PJT7; A5PLR1 [Other Products]
 UniProt Related Accession #    P68431 [Other Products]
 Molecular Weight    136
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 NCBI Official Full Name    Histone H3.1
 NCBI Official Synonym Full Names    histone cluster 1, H3j
 NCBI Official Symbol    HIST1H3J [Similar Products]
 NCBI Official Synonym Symbols   
H3/j; H3FJ
[Similar Products]
 NCBI Protein Information    histone H3.1; histone H3/j; histone 1, H3j; H3 histone family, member J
 UniProt Protein Name    Histone H3.1
 UniProt Synonym Protein Names   
Histone H3/a; Histone H3/b; Histone H3/c; Histone H3/d; Histone H3/f; Histone H3/h; Histone H3/i; Histone H3/j; Histone H3/k; Histone H3/l
 UniProt Gene Name    HIST1H3A [Similar Products]
 UniProt Synonym Gene Names    H3FA [Similar Products]
 UniProt Entry Name    H31_HUMAN
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 NCBI Summary for H3R26me2a    Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Jul 2008]
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 UniProt Comments for H3R26me2a    H3: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. Belongs to the histone H3 family.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 6p22.2

Cellular Component: nucleoplasm; nuclear chromosome; protein complex; membrane; extracellular region; nucleosome; nucleus

Molecular Function: protein binding; DNA binding; histone binding; protein heterodimerization activity

Biological Process: chromatin silencing at rDNA; nucleosome assembly; establishment and/or maintenance of chromatin architecture; negative regulation of gene expression, epigenetic; protein heterotetramerization; gene expression; blood coagulation; DNA replication-dependent nucleosome assembly; regulation of gene expression, epigenetic; DNA methylation on cytosine
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-H3R26me2a antibody
 Products by Pathway  Pathway Diagram
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 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Cellular Senescence Pathway antibodies  Cellular Senescence Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Chromatin Modifying Enzymes Pathway antibodies  Chromatin Modifying Enzymes Pathway Diagram
 Chromatin Organization Pathway antibodies  Chromatin Organization Pathway Diagram
 Condensation Of Prophase Chromosomes Pathway antibodies  Condensation Of Prophase Chromosomes Pathway Diagram
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