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anti-HCK antibody :: Rabbit HCK (Phospho-Tyr521) Antibody

Scan QR to view Datasheet Catalog #    MBS003777 anti-HCK antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HCK (Phospho-Tyr521), Antibody

 Also Known As   

Rabbit HCK (Phospho-Tyr521) Antibody

 Product Gene Name   

anti-HCK antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 20; NC_000020.10 (30639991..30689659). Location: 20q11-q12
 OMIM    142370
 3D Structure    ModBase 3D Structure for P08631
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 Host    Rabbit
 Species Reactivity    Human, mouse, rat
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 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Other Notes    Small volumes of anti-HCK antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-HCK antibody   

ELISA (EIA), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for HCK. It may not necessarily be applicable to this product.
 NCBI GI #    287326139
 NCBI GeneID    3055
 NCBI Accession #    NP_001165600.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001172129.1 [Other Products]
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 UniProt Primary Accession #    P08631 [Other Products]
 UniProt Secondary Accession #    Q29RX1; Q2VPE2; Q504R5; Q5T7K1; Q5T7K2; Q96CC0; Q9H5Y5; Q9NUA4; A8K1I1; B4DQB6; E1P5M2 [Other Products]
 UniProt Related Accession #    P08631 [Other Products]
 Molecular Weight    59,600 Da
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 NCBI Official Full Name    tyrosine-protein kinase HCK isoform b
 NCBI Official Synonym Full Names    hemopoietic cell kinase
 NCBI Official Symbol    HCK [Similar Products]
 NCBI Official Synonym Symbols   
JTK9; p59Hck; p61Hck
[Similar Products]
 NCBI Protein Information    tyrosine-protein kinase HCK; p59-HCK/p60-HCK; hematopoietic cell kinase
 UniProt Protein Name    Tyrosine-protein kinase HCK
 UniProt Synonym Protein Names   
Hematopoietic cell kinase; Hemopoietic cell kinase; p59-HCK/p60-HCK; p59Hck; p61Hck
 Protein Family    Tyrosine-protein kinase
 UniProt Gene Name    HCK [Similar Products]
 UniProt Entry Name    HCK_HUMAN
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 NCBI Summary for HCK    The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Multiple isoforms with different subcellular distributions are produced due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) codon. [provided by RefSeq, Feb 2010]
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 UniProt Comments for HCK    Hck: a protein-tyrosine kinase of the Src family that is predominantly expressed in hemopoietic cell types. The encoded protein may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Alternate translation initiation site usage, including a non-AUG (CUG) codon, results in the production of two different isoforms that have different subcellular localization.

Protein type: EC 2.7.10.2; Protein kinase, TK; Oncoprotein; Protein kinase, tyrosine (non-receptor); Kinase, protein; TK group; Src family

Chromosomal Location of Human Ortholog: 20q11-q12

Cellular Component: Golgi apparatus; transport vesicle; extrinsic to internal side of plasma membrane; focal adhesion; cell projection; lysosome; actin filament; caveola; nucleus; cytosol

Molecular Function: protein binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; ATP binding; receptor binding

Biological Process: integrin-mediated signaling pathway; peptidyl-tyrosine phosphorylation; respiratory burst after phagocytosis; viral reproduction; protein amino acid autophosphorylation; cytokine and chemokine mediated signaling pathway; regulation of phagocytosis; protein amino acid phosphorylation; regulation of defense response to virus by virus; regulation of cell shape; leukocyte migration during immune response; regulation of transcription factor activity; positive regulation of actin filament polymerization; leukocyte degranulation; positive regulation of cell proliferation; regulation of inflammatory response; lipopolysaccharide-mediated signaling pathway; innate immune response; mesoderm development; cell adhesion; cell differentiation; innate immune response-activating signal transduction; inflammatory response; transmembrane receptor protein tyrosine kinase signaling pathway; negative regulation of apoptosis
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 Research Articles on HCK    1. The SRC family tyrosine kinase HCK and the ETS family transcription factors SPIB and EHF regulate transcytosis across a human follicle-associated epithelium model.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-HCK antibodyPathways associated with anti-HCK antibody
 Reference Product  PubMed Publications
 BCR antibody  >34 publications with HCK and BCR
 CSK antibody  >22 publications with HCK and CSK
 CBL antibody  >17 publications with HCK and CBL
 BTK antibody  >13 publications with HCK and BTK
 STAT3 antibody  >11 publications with HCK and STAT3
 KIT antibody  >10 publications with HCK and KIT
 CSF3R antibody  >8 publications with HCK and CSF3R
 VAV1 antibody  >7 publications with HCK and VAV1
 PLAUR antibody  >7 publications with HCK and PLAUR
 vif antibody  >6 publications with HCK and vif
 Products by Pathway  Pathway Diagram
 Alpha-synuclein Signaling Pathway antibodies  Alpha-synuclein Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class I PI3K Signaling Events Pathway antibodies  Class I PI3K Signaling Events Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 EPHA Forward Signaling Pathway antibodies  EPHA Forward Signaling Pathway Diagram
 Ephrin B Reverse Signaling Pathway antibodies  Ephrin B Reverse Signaling Pathway Diagram
Diseases associated with anti-HCK antibodyOrgans/Tissues associated with anti-HCK antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >91 publications with HCK and Neoplasms
 Inflammation Antibodies  >29 publications with HCK and Inflammation
 Necrosis Antibodies  >26 publications with HCK and Necrosis
 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Antibodies  >20 publications with HCK and Leukemia, Myelogenous, Chronic, BCR-ABL Positive
 Carcinoma Antibodies  >20 publications with HCK and Carcinoma
 Drug Toxicity Antibodies  >13 publications with HCK and Drug Toxicity
 Lung Diseases Antibodies  >10 publications with HCK and Lung Diseases
 Kidney Diseases Antibodies  >9 publications with HCK and Kidney Diseases
 Neoplasms, Experimental Antibodies  >7 publications with HCK and Neoplasms, Experimental
 Brain Diseases Antibodies  >7 publications with HCK and Brain Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >193 publications with HCK and Blood
 Lung Antibodies  >19 publications with HCK and Lung
 Kidney Antibodies  >16 publications with HCK and Kidney
 Spleen Antibodies  >13 publications with HCK and Spleen
 Eye Antibodies  >12 publications with HCK and Eye
 Brain Antibodies  >10 publications with HCK and Brain
 Prostate Antibodies  >7 publications with HCK and Prostate
 Testis Antibodies  >6 publications with HCK and Testis
 Ovary Antibodies  >3 publications with HCK and Ovary
 Thymus Antibodies  >3 publications with HCK and Thymus
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