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anti-HEY2 antibody :: Rabbit anti-Human, Mouse HEY2 Antibody

Scan QR to view Datasheet Catalog #    MBS001624
Western blot
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HEY2, Antibody

 Also Known As   

Rabbit HEY2 Antibody

 Product Synonym Names    Hairy/enhancer-of-split related with YRPW motif protein 2, Cardiovascular helix-loop-helix factor 1, hCHF1, Hairy and enhancer of split-related protein 2, HESR-2, Hairy-related transcription factor 2, hHRT2, HES-related repressor protein 2, Protein gridlock homolog, HEY2, CHF1, GRL, HERP, HERP1, HRT2
 Product Gene Name   

anti-HEY2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 6; NC_000006.11 (126070732..126082415). Location: 6q21
 OMIM    604674
 3D Structure    ModBase 3D Structure for Q9UBP5
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 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Specificity    HEY2 antibody detects endogenous levels of total HEY2 protein.
 Purity/Purification    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
 Concentration    1 mg/ml (lot specific)
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 Immunogen    The antiserum was produced against synthesized peptide derived from internal of human HEY2.
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 Preparation and Storage    Store at -20 degree C/1 year
 Other Notes    Small volumes of anti-HEY2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-HEY2 antibody   

ELISA (EIA), Western Blot (WB)

 Application Notes for anti-HEY2 antibody    WB: 1:500~1:3000
ELISA: 1:1000
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 Western blot of anti-HEY2 antibody    Western blot analysis of extracts from K562 cells, using HEY2 antibody.
anti-HEY2 antibody Western blot image
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NCBI/Uniprot data below describe general gene information for HEY2. It may not necessarily be applicable to this product.
 NCBI GI #    6912414
 NCBI GeneID    23493
 NCBI Accession #    NP_036391.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_012259.2 [Other Products]
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 UniProt Primary Accession #    Q9UBP5 [Other Products]
 UniProt Related Accession #    Q9UBP5 [Other Products]
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 NCBI Official Full Name    hairy/enhancer-of-split related with YRPW motif protein 2
 NCBI Official Synonym Full Names    hairy/enhancer-of-split related with YRPW motif 2
 NCBI Official Symbol    HEY2 [Similar Products]
 NCBI Official Synonym Symbols   
GRL; CHF1; HRT2; HERP1; HESR2; bHLHb32; GRIDLOCK
[Similar Products]
 NCBI Protein Information    hairy/enhancer-of-split related with YRPW motif protein 2; HRT-2; hCHF1; hHRT2; HESR-2; protein gridlock homolog; HES-related repressor protein 1; HES-related repressor protein 2; hairy-related transcription factor 2; cardiovascular helix-loop-helix factor 1; class B basic helix-loop-helix protein 32; hairy and enhancer of split-related protein 2; cardiovascular basic helix-loop-helix factor 1
 UniProt Protein Name    Hairy/enhancer-of-split related with YRPW motif protein 2
 UniProt Synonym Protein Names   
Cardiovascular helix-loop-helix factor 1; hCHF1; Class B basic helix-loop-helix protein 32; bHLHb32; HES-related repressor protein 2; Hairy and enhancer of split-related protein 2; HESR-2; Hairy-related transcription factor 2; HRT-2; hHRT2; Protein gridlock homolog
 Protein Family    Hairy/enhancer-of-split related with YRPW motif protein
 UniProt Gene Name    HEY2 [Similar Products]
 UniProt Synonym Gene Names    BHLHB32; CHF1; GRL; HERP; HERP1; HRT2; hCHF1; bHLHb32; HESR-2; HRT-2; hHRT2 [Similar Products]
 UniProt Entry Name    HEY2_HUMAN
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 NCBI Summary for HEY2    This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The encoded protein forms homo- or hetero-dimers that localize to the nucleus and interact with a histone deacetylase complex to repress transcription. Expression of this gene is induced by the Notch signal transduction pathway. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
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 UniProt Comments for HEY2    HEY2: Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'- CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6. Belongs to the HEY family.

Chromosomal Location of Human Ortholog: 6q21

Cellular Component: nucleoplasm; Sin3 complex; transcriptional repressor complex; cytoplasm; nucleus

Molecular Function: protein dimerization activity; protein binding; sequence-specific DNA binding; histone deacetylase binding; transcription factor activity; transcription factor binding

Biological Process: cardiac muscle hypertrophy; transcription from RNA polymerase II promoter; Notch signaling pathway; cell fate commitment; ventricular cardiac muscle cell development; positive regulation of heart rate; negative regulation of transcription from RNA polymerase II promoter; protein-DNA complex assembly; regulation of auditory receptor cell differentiation; negative regulation of Notch signaling pathway; smooth muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; vasculogenesis; mesenchymal cell development; anterior/posterior axis specification; positive regulation of cardiac muscle cell proliferation
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 Research Articles on HEY2    1. Report down-regulation of Notch signaling components NOTCH3 and HEY2 in abdominal aortic aneurysms.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-HEY2 antibodyPathways associated with anti-HEY2 antibody
 Reference Product  PubMed Publications
 SIRT1 antibody  >2 publications with HEY2 and SIRT1
 HAND2 antibody  >2 publications with HEY2 and HAND2
 HDAC1 antibody  >1 publications with HEY2 and HDAC1
 ARNT antibody  >1 publications with HEY2 and ARNT
 Products by Pathway  Pathway Diagram
 Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway Diagram
 Delta-Notch Signaling Pathway antibodies  Delta-Notch Signaling Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 FBXW7 Mutants And NOTCH1 In Cancer Pathway antibodies  FBXW7 Mutants And NOTCH1 In Cancer Pathway Diagram
 Heart Development Pathway antibodies  Heart Development Pathway Diagram
 NOTCH1 Intracellular Domain Regulates Transcription Pathway antibodies  NOTCH1 Intracellular Domain Regulates Transcription Pathway Diagram
 Neural Crest Differentiation Pathway antibodies  Neural Crest Differentiation Pathway Diagram
 Notch-mediated HES/HEY Network Pathway antibodies  Notch-mediated HES/HEY Network Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By NOTCH Pathway antibodies  Signaling By NOTCH Pathway Diagram
Diseases associated with anti-HEY2 antibodyOrgans/Tissues associated with anti-HEY2 antibody
 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >22 publications with HEY2 and Congenital Abnormalities
 Heart Defects, Congenital Antibodies  >21 publications with HEY2 and Heart Defects, Congenital
 Neoplasms Antibodies  >18 publications with HEY2 and Neoplasms
 Hypertrophy Antibodies  >10 publications with HEY2 and Hypertrophy
 Disease Models, Animal Antibodies  >8 publications with HEY2 and Disease Models, Animal
 Fibrosis Antibodies  >6 publications with HEY2 and Fibrosis
 Nervous System Diseases Antibodies  >4 publications with HEY2 and Nervous System Diseases
 Lung Diseases Antibodies  >3 publications with HEY2 and Lung Diseases
 Immune System Diseases Antibodies  >3 publications with HEY2 and Immune System Diseases
 Necrosis Antibodies  >2 publications with HEY2 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >53 publications with HEY2 and Vascular
 Muscle Antibodies  >33 publications with HEY2 and Muscle
 Brain Antibodies  >13 publications with HEY2 and Brain
 Lung Antibodies  >11 publications with HEY2 and Lung
 Bone Antibodies  >11 publications with HEY2 and Bone
 Eye Antibodies  >10 publications with HEY2 and Eye
 Liver Antibodies  >5 publications with HEY2 and Liver
 Ovary Antibodies  >3 publications with HEY2 and Ovary
 Uterus Antibodies  >1 publications with HEY2 and Uterus
 Placenta Antibodies  >1 publications with HEY2 and Placenta
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