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anti-HNRPLL antibody :: Rabbit HNRPLL Antibody

Scan QR to view Datasheet Catalog #    MBS001510 anti-HNRPLL antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HNRPLL, Antibody

 Also Known As   

Rabbit HNRPLL Antibody

 Product Gene Name   

anti-HNRPLL antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 2; NC_000002.11 (38790328..38830178, complement). Location: 2p22.1
 OMIM    611208
 3D Structure    ModBase 3D Structure for Q8WVV9
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 Host    Rabbit
 Species Reactivity    Human, mouse, rat
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 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Other Notes    Small volumes of anti-HNRPLL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-HNRPLL antibody   

ELISA (EIA), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for HNRPLL. It may not necessarily be applicable to this product.
 NCBI GI #    217416379
 NCBI GeneID    92906
 NCBI Accession #    NP_001136122.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001142650.1 [Other Products]
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 UniProt Primary Accession #    Q8WVV9 [Other Products]
 UniProt Secondary Accession #    Q53T80; Q5JB51; Q659B9; Q8IVH5; Q8IVH6; Q96HR5 [Other Products]
 UniProt Related Accession #    Q8WVV9 [Other Products]
 Molecular Weight    60,083 Da
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 NCBI Official Full Name    heterogeneous nuclear ribonucleoprotein L-like isoform 2
 NCBI Official Synonym Full Names    heterogeneous nuclear ribonucleoprotein L-like
 NCBI Official Symbol    HNRNPLL [Similar Products]
 NCBI Official Synonym Symbols   
SRRF; HNRPLL
[Similar Products]
 NCBI Protein Information    heterogeneous nuclear ribonucleoprotein L-like; stromal RNA regulating factor; stromal RNA-regulating factor
 UniProt Protein Name    Heterogeneous nuclear ribonucleoprotein L-like
 UniProt Synonym Protein Names   
Stromal RNA-regulating factor
 UniProt Gene Name    HNRPLL [Similar Products]
 UniProt Synonym Gene Names    SRRF; hnRNPLL [Similar Products]
 UniProt Entry Name    HNRLL_HUMAN
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 NCBI Summary for HNRPLL    HNRNPLL is a master regulator of activation-induced alternative splicing in T cells. In particular, it alters splicing of CD45 (PTPRC; MIM 151460), a tyrosine phosphatase essential for T-cell development and activation (Oberdoerffer et al., 2008 [PubMed 18669861]).[supplied by OMIM, Aug 2008]
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 UniProt Comments for HNRPLL    HNRPLL: RNA-binding protein that functions as regulator of alternative splicing for multiple target mRNAs, including PTPRC/CD45 and STAT5A. Required for alternative splicing of PTPRC. Interacts with HNRNPL. Up-regulated in stimulated T-cells. Widely expressed. Detected in bone marrow stroma cells, skeletal muscle, heart, placenta, pancreas, kidney and lung. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA-binding

Chromosomal Location of Human Ortholog: 2p22.1

Cellular Component: membrane; nucleus; ribonucleoprotein complex

Molecular Function: mRNA binding; protein binding; nucleotide binding

Biological Process: mRNA processing; positive regulation of RNA splicing
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 Research Articles on HNRPLL    1. Loss-of-function mutation of hnRNPLL disrupts peripheral T cell accumulation even in the absence of CD45 protein, indicating that hnRNPLL acts through an independent mechanism to promote peripheral T cell longevity.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with anti-HNRPLL antibodyOrgans/Tissues associated with anti-HNRPLL antibody
 Disease Name  Pubmed Publications
 Death Antibodies  >1 publications with HNRPLL and Death
 Immune System Diseases Antibodies  >1 publications with HNRPLL and Immune System Diseases
 Lymphopenia Antibodies  >1 publications with HNRPLL and Lymphopenia
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >7 publications with HNRPLL and Blood
 Thymus Antibodies  >1 publications with HNRPLL and Thymus
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