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anti-HP1 antibody :: Rabbit anti-Human HP1 alpha Antibody

Scan QR to view Datasheet Catalog #    MBS852359
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HP1 alpha, Antibody

★Popular Item★
 Also Known As   

HP1 alpha (Phospho-Ser92) Antibody

 Product Synonym Names    HP1a (Phospho-Ser92) Antibody; antigen p25; chromobox protein homolog 5; heterochromatin protein 1 alpha; HP1 alpha; HP1A
 Product Gene Name   

anti-HP1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    604478
 3D Structure    ModBase 3D Structure for P45973
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 Host    Rabbit
 Species Reactivity    Human
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 Specificity    HP1alpha (Phospho-Ser92) antibody detects endogenous levels of HP1alpha only when phosphorylated at serine 92.
 Purity/Purification    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation
 Form/Format    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Reactivity Note    Human (Identities = 100%, Positives = 100%)
 Immunogen    The antiserum was produced against synthesized phosphopeptide derived from human HP1alpha around the phosphorylation site of serine 92 (R-K-SP-N-F).
 All Sites    Human: Ser92
 Pathway    Phospho-specific
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 Preparation and Storage    Store at -20 degree C for 1 year
 Other Notes    Small volumes of anti-HP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-HP1 antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-HP1 antibody   

Immunohistochemistry (IHC), ELISA (EIA)

 Application Notes for anti-HP1 antibody    IHC: 1:50~1:100, ELISA: 1:40000
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 Testing Data of anti-HP1 antibody    P-peptide - +
anti-HP1 antibody Testing Data image
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 Testing Data #2 of anti-HP1 antibody    Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using HP1alpha (Phospho-Ser92) antibody.
HP1alpha (Phospho-Ser92) antibody reacts with epitope-specific phosphopeptide and corresponding non-phosphopeptide. The absorbance readings at 450 nM are shown in the ELISA figure.
anti-HP1 antibody Testing Data #2 image
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NCBI/Uniprot data below describe general gene information for HP1. It may not necessarily be applicable to this product.
 NCBI GI #    188035908
 NCBI GeneID    23468
 NCBI Accession #    NP_001120793.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001127321.1 [Other Products]
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 UniProt Primary Accession #    P45973 [Other Products]
 UniProt Secondary Accession #    B2R8T9 [Other Products]
 UniProt Related Accession #    P45973 [Other Products]
 Molecular Weight    22,225 Da
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 NCBI Official Full Name    chromobox protein homolog 5
 NCBI Official Synonym Full Names    chromobox homolog 5
 NCBI Official Symbol    CBX5 [Similar Products]
 NCBI Official Synonym Symbols   
HP1; HP1A; HEL25
[Similar Products]
 NCBI Protein Information    chromobox protein homolog 5; HP1-ALPHA; HP1Hs alpha; antigen p25; HP1 alpha homolog; epididymis luminal protein 25; heterochromatin protein 1-alpha; heterochromatin protein 1 homolog alpha; chromobox homolog 5 (HP1 alpha homolog, Drosophila)
 UniProt Protein Name    Chromobox protein homolog 5
 UniProt Synonym Protein Names   
Antigen p25; Heterochromatin protein 1 homolog alpha; HP1 alpha
 UniProt Gene Name    CBX5 [Similar Products]
 UniProt Synonym Gene Names    HP1A; HP1 alpha [Similar Products]
 UniProt Entry Name    CBX5_HUMAN
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 NCBI Summary for HP1    This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
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 UniProt Comments for HP1    HP1 alpha: Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Interacts with SUV420H1 and SUV420H2. Interacts with HP1BP3. Interacts directly with ATRX, CHAF1A, LBR, NIPBL, SP100, STAM2 and TRIM28 via the chromoshadow domain. Can interact directly with CBX3 via the chromoshadow domain. Interacts with histone H3 methylated at 'Lys- 9'. Interacts with BAHD1, MIS12 and DSN1. Interacts with POGZ; POGZ and PXVXL motif-containing proteins such as INCENP and TRIM28 compete for interaction with CBX5. Interacts with INCENP and TRIM24. Interacts with JC virus agnoprotein; this interaction induces the dissociation of CBX5 from LBR, resulting in destabilization of the nuclear envelope. Interacts with CHAMP1. Interacts with ASXL1.

Protein type: Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 12q13.13

Cellular Component: kinetochore; nucleoplasm; histone methyltransferase complex; PML body; transcriptional repressor complex; histone deacetylase complex; nucleolus; nuclear envelope; nuclear heterochromatin; nucleus; chromocenter

Molecular Function: protein binding, bridging; protein binding; protein homodimerization activity; histone deacetylase binding; chromatin binding; methylated histone residue binding

Biological Process: viral reproduction; blood coagulation; negative regulation of transcription, DNA-dependent
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Product References and Citations for anti-HP1 antibody

   Saunders W.S., J. Cell Sci. 104:573-582(1993).
Ye Q., J. Biol. Chem. 271:14653-14656(1996).
Ye Q., J. Biol. Chem. 272:14983-14989(1997).
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 Research Articles on HP1    1. Data suggest the reduction of Heterochromatin Protein 1 isoforms HP1beta followed by a decrease in HP1alpha contributes to the pathogenesis of thyroid carcinomas, and their loss is a potential marker of thyroid malignancy and metastatic potential, respectively.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-HP1 antibodyPathways associated with anti-HP1 antibody
 Reference Product  PubMed Publications
 CBX3 antibody  >8 publications with HP1 and CBX3
 SUV39H1 antibody  >2 publications with HP1 and SUV39H1
 DNMT3B antibody  >2 publications with HP1 and DNMT3B
 SUV420H2 antibody  >1 publications with HP1 and SUV420H2
 SMARCA4 antibody  >1 publications with HP1 and SMARCA4
 TRIM28 antibody  >1 publications with HP1 and TRIM28
 Products by Pathway  Pathway Diagram
 Aurora B Signaling Pathway antibodies  Aurora B Signaling Pathway Diagram
 E2F Transcription Factor Network Pathway antibodies  E2F Transcription Factor Network Pathway Diagram
 Factors Involved In Megakaryocyte Development And Platelet Production Pathway antibodies  Factors Involved In Megakaryocyte Development And Platelet Production Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
Diseases associated with anti-HP1 antibodyOrgans/Tissues associated with anti-HP1 antibody
 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >2 publications with HP1 and Disease Models, Animal
 Anemia Antibodies  >1 publications with HP1 and Anemia
 Cell Transformation, Neoplastic Antibodies  >1 publications with HP1 and Cell Transformation, Neoplastic
 Breast Neoplasms Antibodies  >1 publications with HP1 and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >3 publications with HP1 and Embryonic Tissue
 Intestine Antibodies  >2 publications with HP1 and Intestine
 Stomach Antibodies  >1 publications with HP1 and Stomach
 Lung Antibodies  >1 publications with HP1 and Lung
 Kidney Antibodies  >1 publications with HP1 and Kidney
 Liver Antibodies  >1 publications with HP1 and Liver
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