NP_001120793.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
22,225 Da
NCBI Official Full Name
chromobox protein homolog 5
NCBI Official Synonym Full Names
chromobox 5
NCBI Protein Information
chromobox protein homolog 5
UniProt Protein Name
Chromobox protein homolog 5
UniProt Synonym Protein Names
Antigen p25; Heterochromatin protein 1 homolog alpha; HP1 alpha
UniProt Synonym Gene Names
NCBI Summary for HP1alpha
This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
UniProt Comments for HP1alpha
Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
Product References and Citations for anti-HP1alpha antibody
Saunders W.S., J. Cell Sci. 104:573-582(1993). Ye Q., J. Biol. Chem. 271:14653-14656(1996). Ye Q., J. Biol. Chem. 272:14983-14989(1997).
Research Articles on HP1alpha
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Products associated with anti-HP1alpha antibody
Pathways associated with anti-HP1alpha antibody
Diseases associated with anti-HP1alpha antibody
Organs/Tissues associated with anti-HP1alpha antibody
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