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anti-HP1alpha antibody :: anti-Human HP1alpha Antibody

Scan QR to view Datasheet Catalog #    MBS854605
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HP1alpha, Antibody

 Also Known As   

HP1alpha (Ab-92) Antibody

 Product Synonym Names    antigen p25; chromobox protein homolog 5; heterochromatin protein 1 alpha; HP1 alpha; HP1A
 Product Gene Name   

anti-HP1alpha antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    604478
 3D Structure    ModBase 3D Structure for P45973
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 Species Reactivity    Human
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 Specificity    HP1alpha (Ab-92) antibody detects endogenous levels of total HP1alpha protein.
 Purity/Purification    Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Immunogen    The antiserum was produced against synthesized non-phosphopeptide derived from human HP1alpha around the phosphorylation site of serine 92 (R-K-SP-N-F).
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 Preparation and Storage    Store at-20 degree C for 1 year.
 Other Notes    Small volumes of anti-HP1alpha antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-HP1alpha antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-HP1alpha antibody   

Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)

 Application Notes for anti-HP1alpha antibody    WB: 1:500~1:1000
IHC: 1:50~1:100
ELISA: 1:1000
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 Testing Data of anti-HP1alpha antibody    Peptide-+
anti-HP1alpha antibody Testing Data image
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 Immunohistochemistry (IHC) of anti-HP1alpha antibody    Immunohistochemistry analysis of paraffin-embedded human braina tissue using HP1alpha (Ab-92) antibody. Western blot analysis of extracts from Jurkat cells, treated with insulin (0.01U/ml, 15mins), using HP1alpha (Ab-92) antibody.
anti-HP1alpha antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for HP1alpha. It may not necessarily be applicable to this product.
 NCBI GI #    188035908
 NCBI GeneID    23468
 NCBI Accession #    NP_001120793.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001127321.1 [Other Products]
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 UniProt Primary Accession #    P45973 [Other Products]
 UniProt Secondary Accession #    B2R8T9 [Other Products]
 UniProt Related Accession #    P45973 [Other Products]
 Molecular Weight    22,225 Da
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 NCBI Official Full Name    chromobox protein homolog 5
 NCBI Official Synonym Full Names    chromobox 5
 NCBI Official Symbol    CBX5 [Similar Products]
 NCBI Official Synonym Symbols   
HP1; HP1A; HEL25
[Similar Products]
 NCBI Protein Information    chromobox protein homolog 5
 UniProt Protein Name    Chromobox protein homolog 5
 UniProt Synonym Protein Names   
Antigen p25; Heterochromatin protein 1 homolog alpha; HP1 alpha
 UniProt Gene Name    CBX5 [Similar Products]
 UniProt Synonym Gene Names    HP1A; HP1 alpha [Similar Products]
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 NCBI Summary for HP1alpha    This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
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 UniProt Comments for HP1alpha    Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
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Product References and Citations for anti-HP1alpha antibody

   Saunders W.S., J. Cell Sci. 104:573-582(1993). The MGC Project Team; Genome Res. 14:2121-2127(2004). Ye Q., J. Biol. Chem. 271:14653-14656(1996).
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 Research Articles on HP1alpha    1. KDM2A-SF forms distinct nuclear heterochromatic bodies in an HP1a dependent manner
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-HP1alpha antibodyPathways associated with anti-HP1alpha antibody
 Reference Product  PubMed Publications
 CBX1 antibody  >9 publications with HP1alpha and CBX1
 CBX3 antibody  >8 publications with HP1alpha and CBX3
 SUV39H1 antibody  >2 publications with HP1alpha and SUV39H1
 DNMT3B antibody  >2 publications with HP1alpha and DNMT3B
 SMARCA4 antibody  >1 publications with HP1alpha and SMARCA4
 E2F1 antibody  >1 publications with HP1alpha and E2F1
 Products by Pathway  Pathway Diagram
 Aurora B Signaling Pathway antibodies  Aurora B Signaling Pathway Diagram
 E2F Transcription Factor Network Pathway antibodies  E2F Transcription Factor Network Pathway Diagram
 Factors Involved In Megakaryocyte Development And Platelet Production Pathway antibodies  Factors Involved In Megakaryocyte Development And Platelet Production Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
Diseases associated with anti-HP1alpha antibodyOrgans/Tissues associated with anti-HP1alpha antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >3 publications with HP1alpha and Neoplasms
 Disease Models, Animal Antibodies  >2 publications with HP1alpha and Disease Models, Animal
 Lung Diseases Antibodies  >1 publications with HP1alpha and Lung Diseases
 Cell Transformation, Neoplastic Antibodies  >1 publications with HP1alpha and Cell Transformation, Neoplastic
 Breast Neoplasms Antibodies  >1 publications with HP1alpha and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >3 publications with HP1alpha and Embryonic Tissue
 Intestine Antibodies  >2 publications with HP1alpha and Intestine
 Stomach Antibodies  >1 publications with HP1alpha and Stomach
 Lung Antibodies  >1 publications with HP1alpha and Lung
 Kidney Antibodies  >1 publications with HP1alpha and Kidney
 Liver Antibodies  >1 publications with HP1alpha and Liver
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