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anti-HSP90AB1 antibody :: Rabbit HSP90AB1-S254 Antibody

Scan QR to view Datasheet Catalog #    MBS128510
Western Blot (WB)
Unit / Price
0.05 mL  /  $265 +1 FREE 8GB USB
0.1 mL  /  $380 +1 FREE 8GB USB
0.2 mL  /  $555 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HSP90AB1-S254, Antibody

 Also Known As   

Phospho-HSP90AB1-S254 Polyclonal Antibody

 Product Synonym Names    Phospho-HSP90AB1-S254: HSP84; HSPC2; HSPCB; D6S182; HSP90B
 Product Gene Name   

anti-HSP90AB1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    140572
 3D Structure    ModBase 3D Structure for P08238
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 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Affinity Purification
 Concentration    1mg/ml (lot specific)
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 Species    Human
 Route    Synthetic Peptide
 Immunogen    A phospho specific peptide corresponding to residues surrounding S254 of human HSP90AB1
 Calculated Molecular Weight    92kDa
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 Preparation and Storage    Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Other Notes    Small volumes of anti-HSP90AB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-HSP90AB1 antibody

   This gene encodes a member of the heat shock protein 90 family; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric apoptosis and inflammation. Alternative splicing results in multiple transcript variants. Pseudogenes have been identified on multiple chromosomes.
 Product Categories/Family for anti-HSP90AB1 antibody    Phosphorylation
 Applications Tested/Suitable for anti-HSP90AB1 antibody   

Western Blot (WB)

 Application Notes for anti-HSP90AB1 antibody    WB: 1:500 - 1:2000
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 Western Blot (WB) of anti-HSP90AB1 antibody    Western blot analysis of extracts from HeLa cells, using Phospho-HSP90AB1-S254 antibody.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% BSA.
anti-HSP90AB1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for HSP90AB1. It may not necessarily be applicable to this product.
 NCBI GI #    17865718
 NCBI GeneID    3326
 NCBI Accession #    P08238.4 [Other Products]
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 UniProt Primary Accession #    P08238 [Other Products]
 UniProt Secondary Accession #    Q5T9W7; Q9NQW0; Q9NTK6; B2R5P0 [Other Products]
 UniProt Related Accession #    P08238 [Other Products]
 Molecular Weight    724
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 NCBI Official Full Name    Heat shock protein HSP 90-beta
 NCBI Official Synonym Full Names    heat shock protein 90kDa alpha (cytosolic), class B member 1
 NCBI Official Symbol    HSP90AB1 [Similar Products]
 NCBI Official Synonym Symbols   
HSP84; HSPC2; HSPCB; D6S182; HSP90B
[Similar Products]
 NCBI Protein Information    heat shock protein HSP 90-beta; HSP90-beta; heat shock 84 kDa; heat shock 90kD protein 1, beta
 UniProt Protein Name    Heat shock protein HSP 90-beta
 UniProt Synonym Protein Names   
Heat shock 84 kDa; HSP 84; HSP84
 Protein Family    Heat shock protein
 UniProt Gene Name    HSP90AB1 [Similar Products]
 UniProt Synonym Gene Names    HSP90B; HSPC2; HSPCB; HSP 90; HSP 84; HSP84 [Similar Products]
 UniProt Entry Name    HS90B_HUMAN
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 NCBI Summary for HSP90AB1    This gene encodes a member of the heat shock protein 90 family; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric apoptosis and inflammation. Alternative splicing results in multiple transcript variants. Pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Dec 2012]
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 UniProt Comments for HSP90AB1    HSP90B: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Homodimer. Interacts with p53/TP53. Forms a complex with CDK6 and Hsp90/HSP90AB1. Interacts with UNC45A. Binding to UNC45A involves 2 UNC45A monomers per HSP90AB1 dimer. Interacts with CHORDC1 and DNAJC7. Interacts with FKBP4. Belongs to the heat shock protein 90 family.

Protein type: Heat shock protein; Chaperone

Chromosomal Location of Human Ortholog: 6p12

Cellular Component: nucleoplasm; signalosome; cell surface; membrane; mitochondrion; brush border membrane; basolateral plasma membrane; apical plasma membrane; cytoplasm; melanosome; inclusion body; cytosol

Molecular Function: protein binding; GTP binding; TPR domain binding; double-stranded RNA binding; unfolded protein binding; nitric-oxide synthase regulator activity; dATP binding; sulfonylurea receptor binding; protein kinase binding; kinase binding; ATP binding

Biological Process: axon guidance; positive regulation of nitric oxide biosynthetic process; positive regulation of protein import into nucleus, translocation; protein folding; positive regulation of cell size; positive regulation of protein binding; innate immune response; negative regulation of neuron apoptosis; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; response to unfolded protein; response to salt stress; placenta development
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 Research Articles on HSP90AB1    1. Hsp90 binds directly to fibronectin (FN) and inhibition reduces the extracellular fibronectin matrix in breast cancer cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-HSP90AB1 antibodyPathways associated with anti-HSP90AB1 antibody
 Reference Product  PubMed Publications
 HSP90AA1 antibody  >12 publications with HSP90AB1 and HSP90AA1
 CDC37 antibody  >2 publications with HSP90AB1 and CDC37
 Products by Pathway  Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Attenuation Phase Pathway antibodies  Attenuation Phase Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Cellular Response To Heat Stress Pathway antibodies  Cellular Response To Heat Stress Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Estrogen Signaling Pathway antibodies  Estrogen Signaling Pathway Diagram
 Estrogen Signaling Pathway antibodies  Estrogen Signaling Pathway Diagram
Diseases associated with anti-HSP90AB1 antibodyOrgans/Tissues associated with anti-HSP90AB1 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >5 publications with HSP90AB1 and Inflammation
 Liver Neoplasms Antibodies  >3 publications with HSP90AB1 and Liver Neoplasms
 Disease Models, Animal Antibodies  >3 publications with HSP90AB1 and Disease Models, Animal
 Lung Neoplasms Antibodies  >3 publications with HSP90AB1 and Lung Neoplasms
 Liver Diseases Antibodies  >3 publications with HSP90AB1 and Liver Diseases
 Infertility, Male Antibodies  >2 publications with HSP90AB1 and Infertility, Male
 Carcinoma, Hepatocellular Antibodies  >2 publications with HSP90AB1 and Carcinoma, Hepatocellular
 Necrosis Antibodies  >2 publications with HSP90AB1 and Necrosis
 Fibrosis Antibodies  >1 publications with HSP90AB1 and Fibrosis
 Kidney Diseases Antibodies  >1 publications with HSP90AB1 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >10 publications with HSP90AB1 and Blood
 Lung Antibodies  >8 publications with HSP90AB1 and Lung
 Brain Antibodies  >7 publications with HSP90AB1 and Brain
 Intestine Antibodies  >5 publications with HSP90AB1 and Intestine
 Ovary Antibodies  >5 publications with HSP90AB1 and Ovary
 Embryonic Tissue Antibodies  >4 publications with HSP90AB1 and Embryonic Tissue
 Kidney Antibodies  >3 publications with HSP90AB1 and Kidney
 Liver Antibodies  >3 publications with HSP90AB1 and Liver
 Bone Antibodies  >3 publications with HSP90AB1 and Bone
 Connective Tissue Antibodies  >3 publications with HSP90AB1 and Connective Tissue
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