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anti-HSP90B antibody :: Rabbit HSP90B (Phospho-Ser226) Antibody

Scan QR to view Datasheet Catalog #    MBS002433 anti-HSP90B antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HSP90B (Phospho-Ser226), Antibody

 Also Known As   

Rabbit HSP90B (Phospho-Ser226) Antibody

 Product Gene Name   

anti-HSP90B antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 6; NC_000006.11 (44214849..44221614). Location: 6p12
 OMIM    140572
 3D Structure    ModBase 3D Structure for P08238
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 Host    Rabbit
 Species Reactivity    Human, mouse, rat
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 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Other Notes    Small volumes of anti-HSP90B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-HSP90B antibody   

ELISA (EIA), Immunofluorescence (IF), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for HSP90B. It may not necessarily be applicable to this product.
 NCBI GI #    431822401
 NCBI GeneID    3326
 NCBI Accession #    NP_001258898.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001271969.1 [Other Products]
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 UniProt Primary Accession #    P08238 [Other Products]
 UniProt Secondary Accession #    Q5T9W7; Q9NQW0; Q9NTK6; B2R5P0 [Other Products]
 UniProt Related Accession #    P08238 [Other Products]
 Molecular Weight    83,264 Da
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 NCBI Official Full Name    heat shock protein HSP 90-beta isoform a
 NCBI Official Synonym Full Names    heat shock protein 90kDa alpha (cytosolic), class B member 1
 NCBI Official Symbol    HSP90AB1 [Similar Products]
 NCBI Official Synonym Symbols   
HSP84; HSPC2; HSPCB; D6S182; HSP90B
[Similar Products]
 NCBI Protein Information    heat shock protein HSP 90-beta; HSP90-beta; heat shock 84 kDa; heat shock 90kD protein 1, beta
 UniProt Protein Name    Heat shock protein HSP 90-beta
 UniProt Synonym Protein Names   
Heat shock 84 kDa
 UniProt Gene Name    HSP90AB1 [Similar Products]
 UniProt Synonym Gene Names    HSP90B; HSPC2; HSPCB; HSP 90; HSP 84; HSP84 [Similar Products]
 UniProt Entry Name    HS90B_HUMAN
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 NCBI Summary for HSP90B    This gene encodes a member of the heat shock protein 90 family; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric apoptosis and inflammation. Alternative splicing results in multiple transcript variants. Pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Dec 2012]
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 UniProt Comments for HSP90B    HSP90B: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Homodimer. Interacts with p53/TP53. Forms a complex with CDK6 and Hsp90/HSP90AB1. Interacts with UNC45A. Binding to UNC45A involves 2 UNC45A monomers per HSP90AB1 dimer. Interacts with CHORDC1 and DNAJC7. Interacts with FKBP4. Belongs to the heat shock protein 90 family.

Protein type: Heat shock protein; Chaperone

Chromosomal Location of Human Ortholog: 6p12

Cellular Component: signalosome; nucleoplasm; cell surface; mitochondrion; membrane; basolateral plasma membrane; brush border membrane; cytoplasm; apical plasma membrane; melanosome; inclusion body; cytosol

Molecular Function: protein binding; GTP binding; TPR domain binding; double-stranded RNA binding; nitric-oxide synthase regulator activity; unfolded protein binding; dATP binding; sulfonylurea receptor binding; protein kinase binding; kinase binding; ATP binding

Biological Process: axon guidance; positive regulation of nitric oxide biosynthetic process; positive regulation of cell size; positive regulation of protein import into nucleus, translocation; protein folding; positive regulation of protein binding; innate immune response; negative regulation of neuron apoptosis; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; response to unfolded protein; response to salt stress; placenta development
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 Research Articles on HSP90B    1. Using a proteomic analysis, we determined that the cleavage occurs in a conserved motif of the N-terminal nucleotide binding site, between Ile-126 and Gly-127 in Hsp90beta, and between Ile-131 and Gly-132 in Hsp90alpha.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-HSP90B antibodyPathways associated with anti-HSP90B antibody
 Reference Product  PubMed Publications
 TSSK6 antibody  >1 publications with HSP90B and TSSK6
 TP53 antibody  >1 publications with HSP90B and TP53
 STAT3 antibody  >1 publications with HSP90B and STAT3
 AKT1 antibody  >1 publications with HSP90B and AKT1
 Products by Pathway  Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Estrogen Signaling Pathway antibodies  Estrogen Signaling Pathway Diagram
 Estrogen Signaling Pathway antibodies  Estrogen Signaling Pathway Diagram
 Fcgamma Receptor (FCGR) Dependent Phagocytosis Pathway antibodies  Fcgamma Receptor (FCGR) Dependent Phagocytosis Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Inflammasomes Pathway antibodies  Inflammasomes Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
Diseases associated with anti-HSP90B antibodyOrgans/Tissues associated with anti-HSP90B antibody
 Disease Name  Pubmed Publications
 Ovarian Diseases Antibodies  >4 publications with HSP90B and Ovarian Diseases
 Nervous System Diseases Antibodies  >4 publications with HSP90B and Nervous System Diseases
 Liver Neoplasms Antibodies  >3 publications with HSP90B and Liver Neoplasms
 Disease Models, Animal Antibodies  >3 publications with HSP90B and Disease Models, Animal
 Liver Diseases Antibodies  >3 publications with HSP90B and Liver Diseases
 Inflammation Antibodies  >3 publications with HSP90B and Inflammation
 Infertility, Male Antibodies  >2 publications with HSP90B and Infertility, Male
 Carcinoma, Hepatocellular Antibodies  >2 publications with HSP90B and Carcinoma, Hepatocellular
 Brain Diseases Antibodies  >2 publications with HSP90B and Brain Diseases
 Lung Neoplasms Antibodies  >2 publications with HSP90B and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >8 publications with HSP90B and Blood
 Brain Antibodies  >6 publications with HSP90B and Brain
 Intestine Antibodies  >4 publications with HSP90B and Intestine
 Lung Antibodies  >4 publications with HSP90B and Lung
 Ovary Antibodies  >4 publications with HSP90B and Ovary
 Kidney Antibodies  >3 publications with HSP90B and Kidney
 Liver Antibodies  >3 publications with HSP90B and Liver
 Embryonic Tissue Antibodies  >3 publications with HSP90B and Embryonic Tissue
 Bone Antibodies  >3 publications with HSP90B and Bone
 Connective Tissue Antibodies  >3 publications with HSP90B and Connective Tissue
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