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anti-HTR1B antibody :: Rabbit HTR1B Antibody

Scan QR to view Datasheet Catalog #    MBS855237
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

HTR1B, Antibody

 Also Known As   

HTR1B Antibody

 Product Synonym Names    5- HT1B; 5-HT-1D-beta; 5-hydroxytryptamine 1B receptor; 5HT1B; HTR1B; HTR1DB; S12; Serotonin 1D beta receptor; Serotonin receptor 1B
 Product Gene Name   

anti-HTR1B antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    182131
 3D Structure    ModBase 3D Structure for P28222
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 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    HTR1B antibody detects endogenous levels of total HTR1B protein.
 Purity/Purification    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Immunogen    The antiserum was produced against synthesized peptide derived from internal of human HTR1B.
 Pathway    GPCR
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 Preparation and Storage    Store at -20 degree C for 1 year
 Other Notes    Small volumes of anti-HTR1B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-HTR1B antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-HTR1B antibody   

Western Blot (WB), Immunofluorescence (IF), ELISA (EIA)

 Application Notes for anti-HTR1B antibody    WB: 1:500~1:1000, IF: 1:100~1:500, ELISA: 1:40000
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 Testing Data of anti-HTR1B antibody    anti-HTR1B antibody Testing Data image
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 Testing Data #2 of anti-HTR1B antibody    Peptide - +
Western blot analysis of extracts from HepG2 cells and MCF-7 cells, using HTR1B antibody.
Immunofluorescence analysis of A549 cells, using HTR1B antibody.
anti-HTR1B antibody Testing Data #2 image
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NCBI/Uniprot data below describe general gene information for HTR1B. It may not necessarily be applicable to this product.
 NCBI GI #    4504533
 NCBI GeneID    3351
 NCBI Accession #    NP_000854.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000863.1 [Other Products]
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 UniProt Primary Accession #    P28222 [Other Products]
 UniProt Secondary Accession #    Q4VAY7 [Other Products]
 UniProt Related Accession #    P28222 [Other Products]
 Molecular Weight    43,568 Da
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 NCBI Official Full Name    5-hydroxytryptamine receptor 1B
 NCBI Official Synonym Full Names    5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
 NCBI Official Symbol    HTR1B [Similar Products]
 NCBI Official Synonym Symbols   
S12; 5-HT1B; HTR1D2; HTR1DB; 5-HT1DB
[Similar Products]
 NCBI Protein Information    5-hydroxytryptamine receptor 1B; 5-HT-1B; 5-HT-1D-beta; serotonin receptor 1B; serotonin 1D beta receptor
 UniProt Protein Name    5-hydroxytryptamine receptor 1B
 UniProt Synonym Protein Names   
S12; Serotonin 1D beta receptor; 5-HT-1D-beta; Serotonin receptor 1B
 Protein Family    5-hydroxytryptamine receptor
 UniProt Gene Name    HTR1B [Similar Products]
 UniProt Synonym Gene Names    HTR1DB; 5-HT-1B; 5-HT1B; 5-HT-1D-beta [Similar Products]
 UniProt Entry Name    5HT1B_HUMAN
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 NCBI Summary for HTR1B    The neurotransmitter serotonin (5-hydroxytryptamine; 5-HT) exerts a wide variety of physiologic functions through a multiplicity of receptors and may be involved in human neuropsychiatric disorders such as anxiety, depression, or migraine. These receptors consist of several main groups subdivided into several distinct subtypes on the basis of their pharmacologic characteristics, coupling to intracellular second messengers, and distribution within the nervous system (Zifa and Fillion, 1992 [PubMed 1359584]). The serotonergic receptors belong to the multigene family of receptors coupled to guanine nucleotide-binding proteins.[supplied by OMIM, Oct 2009]
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 UniProt Comments for HTR1B    5-HT(1B): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR

Chromosomal Location of Human Ortholog: 6q13

Cellular Component: integral to plasma membrane; cytoplasm; plasma membrane

Molecular Function: serotonin binding; serotonin receptor activity; drug binding

Biological Process: vasoconstriction; drinking behavior; negative regulation of synaptic transmission, glutamatergic; response to mineralocorticoid stimulus; bone remodeling; response to cocaine; regulation of dopamine secretion; synaptic transmission; G-protein signaling, coupled to cyclic nucleotide second messenger; negative regulation of serotonin secretion; negative regulation of cAMP biosynthetic process; response to ethanol; serotonin receptor, adenylate cyclase inhibiting pathway; G-protein coupled receptor internalization; protein kinase C activation; negative regulation of synaptic transmission, GABAergic; regulation of behavior
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Product References and Citations for anti-HTR1B antibody

   Weinshank R.L., Proc. Natl. Acad. Sci. U.S.A. 89:3630-3634(1992).
Demchyshyn L., Proc. Natl. Acad. Sci. U.S.A. 89:5522-5526(1992).
Mochizuki D., Biochem. Biophys. Res. Commun. 185:517-523(1992).
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 Research Articles on HTR1B    1. Low level of 5-HT(1B)receptors in limbic system corelates to decreased serotonin function in patients with Parkinson disease.(review)
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-HTR1B antibodyPathways associated with anti-HTR1B antibody
 Reference Product  PubMed Publications
 HTR1A antibody  >33 publications with HTR1B and HTR1A
 DRD4 antibody  >22 publications with HTR1B and DRD4
 HTR1D antibody  >9 publications with HTR1B and HTR1D
 ADRA2A antibody  >7 publications with HTR1B and ADRA2A
 NPY antibody  >2 publications with HTR1B and NPY
 GAL antibody  >1 publications with HTR1B and GAL
 Products by Pathway  Pathway Diagram
 Amine Ligand-binding Receptors Pathway antibodies  Amine Ligand-binding Receptors Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Monoamine GPCRs Pathway antibodies  Monoamine GPCRs Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Serotonergic Synapse Pathway antibodies  Serotonergic Synapse Pathway Diagram
Diseases associated with anti-HTR1B antibodyOrgans/Tissues associated with anti-HTR1B antibody
 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >95 publications with HTR1B and Mental Disorders
 Nervous System Diseases Antibodies  >49 publications with HTR1B and Nervous System Diseases
 Brain Diseases Antibodies  >41 publications with HTR1B and Brain Diseases
 Migraine Disorders Antibodies  >39 publications with HTR1B and Migraine Disorders
 Headache Antibodies  >25 publications with HTR1B and Headache
 Mood Disorders Antibodies  >23 publications with HTR1B and Mood Disorders
 Depressive Disorder Antibodies  >17 publications with HTR1B and Depressive Disorder
 Pain Antibodies  >17 publications with HTR1B and Pain
 Anxiety Disorders Antibodies  >15 publications with HTR1B and Anxiety Disorders
 Depressive Disorder, Major Antibodies  >12 publications with HTR1B and Depressive Disorder, Major
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >88 publications with HTR1B and Brain
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