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anti-HCF2 antibody :: Heparin Cofactor II Antibody

Scan QR to view Datasheet Catalog #    MBS854395
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Heparin Cofactor II (HCF2), Antibody

 Also Known As   

Heparin Cofactor II Antibody

 Product Synonym Names    Heparin cofactor 2 [Precursor]; Heparin cofactor II; HC-II; Protease inhibitor leuserpin 2; HLS2; SERPIND1
 Product Gene Name   

anti-HCF2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    142360
 3D Structure    ModBase 3D Structure for P05546
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 Species Reactivity    Human, Mouse, Rat
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 Specificity    Heparin Cofactor II antibody detects endogenous levels of total Heparin Cofactor II protein.
 Purity/Purification    Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Immunogen    The antiserum was produced against synthesized peptide derived from internal of human Heparin Cofactor II.
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 Preparation and Storage    Store at-20 degree C for 1 year.
 Other Notes    Small volumes of anti-HCF2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-HCF2 antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-HCF2 antibody   

Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)

 Application Notes for anti-HCF2 antibody    IHC: 1:50-1:100
IF: 1:100-1:500
ELISA: 1:5000
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 Testing Data of anti-HCF2 antibody    Peptide-+
anti-HCF2 antibody Testing Data image
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 Immunohistochemistry (IHC) of anti-HCF2 antibody    Peptide-+ Immunohistochemistry analysis of paraffin-embedded human liver carcinoma tissue, using Heparin Cofactor II antibody. Immunofluorescence analysis of HepG2 cells, using Heparin Cofactor II antibody.
anti-HCF2 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for HCF2. It may not necessarily be applicable to this product.
 NCBI GI #    73858566
 NCBI GeneID    3053
 NCBI Accession #    NP_000176.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000185.3 [Other Products]
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 UniProt Primary Accession #    P05546 [Other Products]
 UniProt Secondary Accession #    Q6IBZ5; B2RAI1; D3DX34 [Other Products]
 UniProt Related Accession #    P05546 [Other Products]
 Molecular Weight    57,071 Da
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 NCBI Official Full Name    heparin cofactor 2
 NCBI Official Synonym Full Names    serpin family D member 1
 NCBI Official Symbol    SERPIND1 [Similar Products]
 NCBI Official Synonym Symbols   
HC2; LS2; HCF2; HCII; HLS2; THPH10; D22S673
[Similar Products]
 NCBI Protein Information    heparin cofactor 2
 UniProt Protein Name    Heparin cofactor 2
 UniProt Synonym Protein Names   
Heparin cofactor II; HC-II; Protease inhibitor leuserpin-2; HLS2; Serpin D1
 UniProt Gene Name    SERPIND1 [Similar Products]
 UniProt Synonym Gene Names    HCF2; HC-II; HLS2 [Similar Products]
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 NCBI Summary for HCF2    This gene belongs to the serpin gene superfamily. Serpins play roles in many processes including inflammation, blood clotting, and cancer metastasis. Members of this family have highly conserved secondary structures with a reactive center loop that interacts with the protease active site to inhibit protease activity. This gene encodes a plasma serine protease that functions as a thrombin and chymotrypsin inhibitor. The protein is activated by heparin, dermatan sulfate, and glycosaminoglycans. Allelic variations in this gene are associated with heparin cofactor II deficiency. [provided by RefSeq, Jul 2015]
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 UniProt Comments for HCF2    Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner.
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Product References and Citations for anti-HCF2 antibody

   Blinder M.A., Biochemistry 27:752-759(1988). Herzog R., Biochemistry 30:1350-1357(1991). Collins J.E., Genome Biol. 5:RESEARCH84.1-RESEARCH84.11(2004).
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 Research Articles on HCF2    1. The plasma level of alpha2M was found positively correlated, while HCII level was negatively correlated with higher vulnerability of carotid plaques. Both proteins were efficient in differentiating stable and vulnerable carotid plaques. These provide potential new targets for the research of carotid plaque vulnerability. Plasma alpha2M and HCII may be potential biomarkers for evaluation of the vulnerability of carotid ...
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-HCF2 antibodyDiseases associated with anti-HCF2 antibody
 Products by Pathway  Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Disease Name  Pubmed Publications
 Atherosclerosis Antibodies  >3 publications with HCF2 and Atherosclerosis
 Death Antibodies  >1 publications with HCF2 and Death
 Heart Diseases Antibodies  >1 publications with HCF2 and Heart Diseases
 Liver Diseases Antibodies  >1 publications with HCF2 and Liver Diseases
 Hyperplasia Antibodies  >1 publications with HCF2 and Hyperplasia
 Necrosis Antibodies  >1 publications with HCF2 and Necrosis
 Heparin Cofactor II Deficiency Antibodies  >1 publications with HCF2 and Heparin Cofactor II Deficiency
Organs/Tissues associated with anti-HCF2 antibody
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >5 publications with HCF2 and Liver
 Vascular Antibodies  >3 publications with HCF2 and Vascular
 Kidney Antibodies  >1 publications with HCF2 and Kidney
 Lung Antibodies  >1 publications with HCF2 and Lung
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