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anti-SERPIND1 antibody :: Rabbit Heparin Cofactor II Antibody

Scan QR to view Datasheet Catalog #    MBS854395
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Heparin Cofactor II (SERPIND1), Antibody

 Also Known As   

Heparin Cofactor II Antibody

 Product Synonym Names    Heparin cofactor 2 [Precursor]; Heparin cofactor II; HC-II; Protease inhibitor leuserpin 2; HLS2; SERPIND1; HCF2
 Product Gene Name   

anti-SERPIND1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 612356
 3D Structure    ModBase 3D Structure for P05546
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 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    Heparin Cofactor II antibody detects endogenous levels of total Heparin Cofactor II protein.
 Purity/Purification    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Reactivity Note    Human (Identities = 100%, Positives = 100%); Mouse (Identities = 100%, Positives = 100%); Rat (Identities = 100%, Positives = 100%)
 Immunogen    The antiserum was produced against synthesized peptide derived from internal of human Heparin Cofactor II.
 Pathway    Intermediates
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 Preparation and Storage    Store at -20 degree C for 1 year
 Other Notes    Small volumes of anti-SERPIND1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-SERPIND1 antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-SERPIND1 antibody   

Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)

 Application Notes for anti-SERPIND1 antibody    IHC: 1:50~1:100, IF: 1:100~1:500, ELISA: 1:5000
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 Testing Data of anti-SERPIND1 antibody    anti-SERPIND1 antibody Testing Data image
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 Testing Data #2 of anti-SERPIND1 antibody    Peptide - +
Immunohistochemistry analysis of paraffin-embedded human liver carcinoma tissue, using Heparin Cofactor II antibody.
Immunofluorescence analysis of HepG2 cells, using Heparin Cofactor II antibody.
anti-SERPIND1 antibody Testing Data #2 image
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NCBI/Uniprot data below describe general gene information for SERPIND1. It may not necessarily be applicable to this product.
 NCBI GI #    73858566
 NCBI GeneID    3053
 NCBI Accession #    NP_000176.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000185.3 [Other Products]
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 UniProt Primary Accession #    P05546 [Other Products]
 UniProt Secondary Accession #    Q6IBZ5; B2RAI1; D3DX34 [Other Products]
 UniProt Related Accession #    P05546 [Other Products]
 Molecular Weight    57,071 Da [Similar Products]
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 NCBI Official Full Name    heparin cofactor 2
 NCBI Official Synonym Full Names    serpin peptidase inhibitor, clade D (heparin cofactor), member 1
 NCBI Official Symbol    SERPIND1 [Similar Products]
 NCBI Official Synonym Symbols   
HC2; LS2; HCF2; HCII; HLS2; THPH10; D22S673
[Similar Products]
 NCBI Protein Information    heparin cofactor 2; serpin D1; leuserpin 2; protease inhibitor leuserpin-2; serine (or cysteine) proteinase inhibitor, clade D (heparin cofactor), member 1
 UniProt Protein Name    Heparin cofactor 2
 UniProt Synonym Protein Names   
Heparin cofactor II; HC-II; Protease inhibitor leuserpin-2; HLS2; Serpin D1
 Protein Family    Heparin cofactor
 UniProt Gene Name    SERPIND1 [Similar Products]
 UniProt Synonym Gene Names    HCF2; HC-II; HLS2 [Similar Products]
 UniProt Entry Name    HEP2_HUMAN
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 NCBI Summary for SERPIND1    The product encoded by this gene is a serine proteinase inhibitor which rapidly inhibits thrombin in the presence of dermatan sulfate or heparin. The gene contains five exons and four introns. This protein shares homology with antithrombin III and other members of the alpha 1-antitrypsin superfamily. Mutations in this gene are associated with heparin cofactor II deficiency. [provided by RefSeq, Jul 2008]
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 UniProt Comments for SERPIND1    SERPIND1: Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner. Defects in SERPIND1 are the cause of thrombophilia due to heparin cofactor 2 deficiency (THPH10). A hemostatic disorder characterized by a tendency to recurrent thrombosis. Belongs to the serpin family.

Chromosomal Location of Human Ortholog: 22q11.21

Cellular Component: extracellular space; extracellular region

Molecular Function: heparin binding; serine-type endopeptidase inhibitor activity; endopeptidase inhibitor activity

Biological Process: chemotaxis; blood coagulation

Disease: Heparin Cofactor Ii Deficiency
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Product References and Citations for anti-SERPIND1 antibody

   Blinder M.A., Biochemistry 27:752-759(1988).
Herzog R., Biochemistry 30:1350-1357(1991).
Collins J.E., Genome Biol. 5:RESEARCH84.1-RESEARCH84.11(2004).
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 Research Articles on SERPIND1    1. In this study, we demonstrate a previously unknown role for HCII in host defense.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SERPIND1 antibodyPathways associated with anti-SERPIND1 antibody
 Reference Product  PubMed Publications
 SERPINC1 antibody  >3 publications with SERPIND1 and SERPINC1
 Products by Pathway  Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
Diseases associated with anti-SERPIND1 antibodyOrgans/Tissues associated with anti-SERPIND1 antibody
 Disease Name  Pubmed Publications
 Death Antibodies  >1 publications with SERPIND1 and Death
 Heart Diseases Antibodies  >1 publications with SERPIND1 and Heart Diseases
 Liver Diseases Antibodies  >1 publications with SERPIND1 and Liver Diseases
 Hyperplasia Antibodies  >1 publications with SERPIND1 and Hyperplasia
 Necrosis Antibodies  >1 publications with SERPIND1 and Necrosis
 Heparin Cofactor II Deficiency Antibodies  >1 publications with SERPIND1 and Heparin Cofactor II Deficiency
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >5 publications with SERPIND1 and Liver
 Vascular Antibodies  >3 publications with SERPIND1 and Vascular
 Kidney Antibodies  >1 publications with SERPIND1 and Kidney
 Lung Antibodies  >1 publications with SERPIND1 and Lung
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