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anti-HIST1H2AI antibody :: Histone H2A Antibody

Scan QR to view Datasheet Catalog #    MBS852710
Immunohistochemistry (IHC)
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Histone H2A (HIST1H2AI), Antibody

★Popular Item★
 Also Known As   

Histone H2A (Phospho-Thr121) Antibody

 Product Synonym Names    H2A.1b; H2A/c; H2A/d; H2A/i; H2A/n; H2A/p; H2A1; H2AC; H2AFC; H2AFD ANDHIST1H2AL; H2AFI; H2AFN ANDHIST1H2AG; H2AFP; HIST1H2AI; HIST1H2AJ; HIST1H2AM; Histone H2A.c/d/i/n/p
 Product Gene Name   

anti-HIST1H2AI antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602787
 3D Structure    ModBase 3D Structure for P0C0S8
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 Species Reactivity    Human, Mouse, Rat
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 Specificity    Histone H2A (Phospho-Thr121) antibody detects endogenous levels of Histone H2A only when phosphorylated at threonine 121.
 Purity/Purification    Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
 Form/Format    In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Immunogen    The antiserum was produced against synthesized phosphopeptide derived from human Histone H2A around the phosphorylation site of threonine 121 (K-K-TP-E-S).
 All Sites    Human: Thr121
Mouse: Thr121
Rat: Thr121
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 Preparation and Storage    Store at-20 degree C for 1 year.
 Other Notes    Small volumes of anti-HIST1H2AI antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-HIST1H2AI antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-HIST1H2AI antibody   

Immunohistochemistry (IHC), ELISA (EIA)

 Application Notes for anti-HIST1H2AI antibody    IHC: 1:50-1:100
ELISA: 1:1000
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 Immunohistochemistry (IHC) of anti-HIST1H2AI antibody    P-peptide-+ Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue using Histone H2A (Phospho-Thr121) antibody.
anti-HIST1H2AI antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for HIST1H2AI. It may not necessarily be applicable to this product.
 NCBI GI #    4504239
 NCBI GeneID    8329
 NCBI Accession #    NP_003500.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_003509.2 [Other Products]
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 UniProt Primary Accession #    P0C0S8 [Other Products]
 UniProt Secondary Accession #    P02261; Q2M1R2; Q76PA6 [Other Products]
 UniProt Related Accession #    P0C0S8 [Other Products]
 Molecular Weight    14,091 Da [Similar Products]
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 NCBI Official Full Name    histone H2A type 1
 NCBI Official Synonym Full Names    histone cluster 1 H2A family member i
 NCBI Official Symbol    HIST1H2AI [Similar Products]
 NCBI Official Synonym Symbols   
H2A/c; H2AFC
[Similar Products]
 NCBI Protein Information    histone H2A type 1
 UniProt Protein Name    Histone H2A type 1
 UniProt Synonym Protein Names   
Histone H2A/ptl
 Protein Family    Histone
 UniProt Gene Name    HIST1H2AG [Similar Products]
 UniProt Synonym Gene Names    H2AFP; H2A.1 [Similar Products]
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 NCBI Summary for HIST1H2AI    Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
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 UniProt Comments for HIST1H2AI    Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
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Product References and Citations for anti-HIST1H2AI antibody

   Albig W., Hum. Genet. 101:284-294(1997). Albig W., Biol. Chem. 380:7-18(1999). Dobner T., DNA Seq. 1:409-413(1991).
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-HIST1H2AI antibody
 Products by Pathway  Pathway Diagram
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 Chromatin Organization Pathway antibodies  Chromatin Organization Pathway Diagram
 HATs Acetylate Histones Pathway antibodies  HATs Acetylate Histones Pathway Diagram
 HDACs Deacetylate Histones Pathway antibodies  HDACs Deacetylate Histones Pathway Diagram
 RMTs Methylate Histone Arginines Pathway antibodies  RMTs Methylate Histone Arginines Pathway Diagram
 Systemic Lupus Erythematosus Pathway antibodies  Systemic Lupus Erythematosus Pathway Diagram
 Systemic Lupus Erythematosus Pathway antibodies  Systemic Lupus Erythematosus Pathway Diagram
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