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anti-NFKBIA antibody :: Rabbit I kappa B-alpha Antibody

Scan QR to view Datasheet Catalog #    MBS854170
Testing Data
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

I kappa B-alpha (NFKBIA), Antibody

 Also Known As   

I kappa B-alpha Antibody

 Product Synonym Names    IkB-a Antibody; I-kappa-B-alpha; IkappaBalpha; IKBA; MAD3; Major histocompatibility complex enhancer-binding protein MAD3; NF-kappaB inhibitor alpha; NFKBI; NFKBIA; RL/IF-1
 Product Gene Name   

anti-NFKBIA antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 612132
 3D Structure    ModBase 3D Structure for P25963
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 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    IkappaB-alpha antibody detects endogenous levels of total IkappaB-alpha protein.
 Purity/Purification    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Reactivity Note    Human (Identities = 100%, Positives = 100%); Mouse (Identities = 100%, Positives = 100%); Rat (Identities = 100%, Positives = 100%)
 Immunogen    The antiserum was produced against synthesized peptide derived from N-terminal of human IkappaB-alpha.
 Pathway    Transcription
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 Preparation and Storage    Store at -20 degree C for 1 year
 Other Notes    Small volumes of anti-NFKBIA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-NFKBIA antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-NFKBIA antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-NFKBIA antibody    WB: 1:500~1:1000, ELISA: 1:40000
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 Testing Data of anti-NFKBIA antibody    Western blot analysis of extracts from HuvEc cells, using IkappaB-alpha antibody.
anti-NFKBIA antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for NFKBIA. It may not necessarily be applicable to this product.
 NCBI GI #    10092619
 NCBI GeneID    4792
 NCBI Accession #    NP_065390.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_020529.2 [Other Products]
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 UniProt Primary Accession #    P25963 [Other Products]
 UniProt Secondary Accession #    B2R8L6 [Other Products]
 UniProt Related Accession #    P25963 [Other Products]
 Molecular Weight    35,609 Da [Similar Products]
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 NCBI Official Full Name    NF-kappa-B inhibitor alpha
 NCBI Official Synonym Full Names    nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
 NCBI Official Symbol    NFKBIA [Similar Products]
 NCBI Official Synonym Symbols   
IKBA; MAD-3; NFKBI
[Similar Products]
 NCBI Protein Information    NF-kappa-B inhibitor alpha; ikB-alpha; IkappaBalpha; I-kappa-B-alpha; nuclear factor of kappa light chain gene enhancer in B-cells; major histocompatibility complex enhancer-binding protein MAD3
 UniProt Protein Name    NF-kappa-B inhibitor alpha
 UniProt Synonym Protein Names   
I-kappa-B-alpha; IkB-alpha; IkappaBalpha; Major histocompatibility complex enhancer-binding protein MAD3
 Protein Family    NF-kappa-B inhibitor
 UniProt Gene Name    NFKBIA [Similar Products]
 UniProt Synonym Gene Names    IKBA; MAD3; NFKBI; IkB-alpha; IkappaBalpha [Similar Products]
 UniProt Entry Name    IKBA_HUMAN
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 NCBI Summary for NFKBIA    This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease. [provided by RefSeq, Aug 2011]
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 UniProt Comments for NFKBIA    IkB-alpha: a regulatory protein that inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. May be involved in regulation of transcriptional responses to NF-kappa-B, including cell adhesion, immune and proinflammatory responses, apoptosis, differentiation and growth. Controlled by sequential serine-phosphorylation, ubiquitination and degradation.

Protein type: DNA-binding; Inhibitor

Chromosomal Location of Human Ortholog: 14q13

Cellular Component: cytoplasm; plasma membrane; cytosol; nucleus

Molecular Function: identical protein binding; NF-kappaB binding; protein binding; enzyme binding; ubiquitin protein ligase binding; heat shock protein binding; nuclear localization sequence binding; protein complex binding; transcription factor binding

Biological Process: viral reproduction; nerve growth factor receptor signaling pathway; apoptosis; positive regulation of cellular protein metabolic process; toll-like receptor 3 signaling pathway; T cell receptor signaling pathway; toll-like receptor 10 signaling pathway; activation of NF-kappaB transcription factor; toll-like receptor 5 signaling pathway; response to exogenous dsRNA; cytoplasmic sequestering of NF-kappaB; lipopolysaccharide-mediated signaling pathway; positive regulation of interferon type I production; toll-like receptor 4 signaling pathway; cytoplasmic sequestering of transcription factor; negative regulation of myeloid cell differentiation; MyD88-independent toll-like receptor signaling pathway; negative regulation of DNA binding; regulation of NF-kappaB import into nucleus; toll-like receptor 2 signaling pathway; regulation of cell proliferation; MyD88-dependent toll-like receptor signaling pathway; inhibition of NF-kappaB transcription factor; protein import into nucleus, translocation; response to muramyl dipeptide; toll-like receptor signaling pathway; negative regulation of Notch signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter; toll-like receptor 9 signaling pathway; negative regulation of apoptosis

Disease: Ectodermal Dysplasia, Anhidrotic, With T-cell Immunodeficiency, Autosomal Dominant
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Product References and Citations for anti-NFKBIA antibody

   Haskill S., Cell 65:1281-1289(1991).
Jungnickel B., J. Exp. Med. 191:395-402(2000).
Liu B., Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases.
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 Research Articles on NFKBIA    1. Data indicate that following bortezomib treatment there was accumulation of IkappaB-alpha (IkappaBalpha) without affecting its phosphorylation status at an early time point.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-NFKBIA antibodyPathways associated with anti-NFKBIA antibody
 Reference Product  PubMed Publications
 NFKB1 antibody  >34 publications with NFKBIA and NFKB1
 RELA antibody  >17 publications with NFKBIA and RELA
 IKBKB antibody  >15 publications with NFKBIA and IKBKB
 CHUK antibody  >5 publications with NFKBIA and CHUK
 UBC antibody  >2 publications with NFKBIA and UBC
 SRC antibody  >1 publications with NFKBIA and SRC
 IKBKG antibody  >1 publications with NFKBIA and IKBKG
 Products by Pathway  Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Activation Of NF-kappaB In B Cells Pathway antibodies  Activation Of NF-kappaB In B Cells Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Modulation And Signaling Pathway antibodies  Apoptosis Modulation And Signaling Pathway Diagram
Diseases associated with anti-NFKBIA antibodyOrgans/Tissues associated with anti-NFKBIA antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >37 publications with NFKBIA and Inflammation
 Necrosis Antibodies  >20 publications with NFKBIA and Necrosis
 Nervous System Diseases Antibodies  >9 publications with NFKBIA and Nervous System Diseases
 Liver Diseases Antibodies  >9 publications with NFKBIA and Liver Diseases
 Psoriasis Antibodies  >8 publications with NFKBIA and Psoriasis
 Hodgkin Disease Antibodies  >7 publications with NFKBIA and Hodgkin Disease
 Neoplasms, Experimental Antibodies  >6 publications with NFKBIA and Neoplasms, Experimental
 Heart Diseases Antibodies  >6 publications with NFKBIA and Heart Diseases
 Liver Neoplasms Antibodies  >5 publications with NFKBIA and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >4 publications with NFKBIA and Carcinoma, Hepatocellular
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >35 publications with NFKBIA and Blood
 Liver Antibodies  >13 publications with NFKBIA and Liver
 Lung Antibodies  >13 publications with NFKBIA and Lung
 Brain Antibodies  >12 publications with NFKBIA and Brain
 Vascular Antibodies  >9 publications with NFKBIA and Vascular
 Bone Antibodies  >9 publications with NFKBIA and Bone
 Skin Antibodies  >7 publications with NFKBIA and Skin
 Heart Antibodies  >7 publications with NFKBIA and Heart
 Kidney Antibodies  >5 publications with NFKBIA and Kidney
 Muscle Antibodies  >4 publications with NFKBIA and Muscle
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