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anti-IGFBP-3 antibody :: anti-Human, Mouse IGFBP-3 Antibody

Scan QR to view Datasheet Catalog #    MBS859480
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IGFBP-3, Antibody

★Popular Item★
 Also Known As   

IGFBP-3 (Phospho-Ser183) Antibody

 Product Synonym Names    IBP-3; IBP3; IGF-binding protein 3; IGFBP3; Insulin-like growth factor binding protein 3 precursor
 Product Gene Name   

anti-IGFBP-3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    146732
 3D Structure    ModBase 3D Structure for P17936
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 Species Reactivity    Human, Mouse
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 Specificity    IGFBP-3 (Phospho-Ser183) antibody detects endogenous levels of IGFBP-3 only when phosphorylated at serine 183.
 Purity/Purification    Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
 Form/Format    In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Immunogen    The antiserum was produced against synthesized phosphopeptide derived from human IGFBP-3 around the phosphorylation site of serine 183 (K-D-SP-Q-R).
 All Sites    Human: Ser183
Mouse: Ser183
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 Preparation and Storage    Store at-20 degree C for 1 year.
 Other Notes    Small volumes of anti-IGFBP-3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-IGFBP-3 antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-IGFBP-3 antibody   

Immunohistochemistry (IHC), ELISA (EIA)

 Application Notes for anti-IGFBP-3 antibody    IHC: 1:50-1:100
ELISA: 1:1000
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 Testing Data of anti-IGFBP-3 antibody    P-peptide-+
anti-IGFBP-3 antibody Testing Data image
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 Immunohistochemistry (IHC) of anti-IGFBP-3 antibody    Immunohistochemistry analysis of paraffin-embedded human brain tissue using IGFBP-3 (Phospho-Ser183) antibody. IGFBP-3 (Phospho-Ser183) antibody reacts with epitope-specific phosphopeptide and corresponding non-phosphopeptide. The absorbance readings at 450 nM are shown in the ELISA figure.
anti-IGFBP-3 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for IGFBP-3. It may not necessarily be applicable to this product.
 NCBI GI #    62243068
 NCBI GeneID    3486
 NCBI Accession #    NP_000589.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000598.4 [Other Products]
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 UniProt Primary Accession #    P17936 [Other Products]
 UniProt Secondary Accession #    Q2V509; Q6P1M6; Q9UCL4; A4D2F5; D3DVM0 [Other Products]
 UniProt Related Accession #    P17936 [Other Products]
 Molecular Weight    32,223 Da
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 NCBI Official Full Name    insulin-like growth factor-binding protein 3 isoform b
 NCBI Official Synonym Full Names    insulin like growth factor binding protein 3
 NCBI Official Symbol    IGFBP3 [Similar Products]
 NCBI Official Synonym Symbols   
IBP3; BP-53
[Similar Products]
 NCBI Protein Information    insulin-like growth factor-binding protein 3
 UniProt Protein Name    Insulin-like growth factor-binding protein 3
 UniProt Gene Name    IGFBP3 [Similar Products]
 UniProt Synonym Gene Names    IBP3; IBP-3; IGF-binding protein 3; IGFBP-3 [Similar Products]
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 NCBI Summary for IGFBP-3    This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
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 UniProt Comments for IGFBP-3    IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R.
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Product References and Citations for anti-IGFBP-3 antibody

   C. Schmid, Am J Physiol Endocrinol Metab, Aug 1994; 267: E226-E233. Hanh Le, Am J Physiol Endocrinol Metab, May 2006; 290: E952-E960. C. A. Gibson, J Anim Sci, Jun 1999; 77: 1547-1557.
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 Research Articles on IGFBP-3    1. Our data indicate that targeting IGFBP-3-dependent signaling pathways through gefitinib-FTY720 co-therapy may be effective in many basal-like breast cancers, and suggest tissue IGFBP-3 and CD44 measurement as potential biomarkers of treatment efficacy.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-IGFBP-3 antibodyPathways associated with anti-IGFBP-3 antibody
 Reference Product  PubMed Publications
 IGF1R antibody  >250 publications with IGFBP-3 and IGF1R
 IGF1 antibody  >174 publications with IGFBP-3 and IGF1
 IGF2 antibody  >61 publications with IGFBP-3 and IGF2
 IGFALS antibody  >16 publications with IGFBP-3 and IGFALS
 CAV1 antibody  >7 publications with IGFBP-3 and CAV1
 COL1A1 antibody  >5 publications with IGFBP-3 and COL1A1
 MMP2 antibody  >5 publications with IGFBP-3 and MMP2
 CD44 antibody  >4 publications with IGFBP-3 and CD44
 MMP3 antibody  >4 publications with IGFBP-3 and MMP3
 GPI antibody  >3 publications with IGFBP-3 and GPI
 Products by Pathway  Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 Integrated Pancreatic Cancer Pathway antibodies  Integrated Pancreatic Cancer Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Myometrial Relaxation And Contraction Pathways antibodies  Myometrial Relaxation And Contraction Pathways Diagram
 Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway antibodies  Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway Diagram
 Senescence And Autophagy Pathway antibodies  Senescence And Autophagy Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
 P53 Signaling Pathway antibodies  P53 Signaling Pathway Diagram
 P53 Signaling Pathway antibodies  P53 Signaling Pathway Diagram
Diseases associated with anti-IGFBP-3 antibodyOrgans/Tissues associated with anti-IGFBP-3 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >1188 publications with IGFBP-3 and Neoplasms
 Breast Neoplasms Antibodies  >322 publications with IGFBP-3 and Breast Neoplasms
 Prostatic Neoplasms Antibodies  >243 publications with IGFBP-3 and Prostatic Neoplasms
 Cardiovascular Diseases Antibodies  >202 publications with IGFBP-3 and Cardiovascular Diseases
 Adenocarcinoma Antibodies  >164 publications with IGFBP-3 and Adenocarcinoma
 Colorectal Neoplasms Antibodies  >138 publications with IGFBP-3 and Colorectal Neoplasms
 Liver Diseases Antibodies  >135 publications with IGFBP-3 and Liver Diseases
 Kidney Diseases Antibodies  >119 publications with IGFBP-3 and Kidney Diseases
 Inflammation Antibodies  >107 publications with IGFBP-3 and Inflammation
 Lung Neoplasms Antibodies  >101 publications with IGFBP-3 and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2680 publications with IGFBP-3 and Blood
 Bone Antibodies  >483 publications with IGFBP-3 and Bone
 Liver Antibodies  >391 publications with IGFBP-3 and Liver
 Prostate Antibodies  >332 publications with IGFBP-3 and Prostate
 Muscle Antibodies  >275 publications with IGFBP-3 and Muscle
 Connective Tissue Antibodies  >206 publications with IGFBP-3 and Connective Tissue
 Vascular Antibodies  >202 publications with IGFBP-3 and Vascular
 Kidney Antibodies  >198 publications with IGFBP-3 and Kidney
 Brain Antibodies  >183 publications with IGFBP-3 and Brain
 Lung Antibodies  >166 publications with IGFBP-3 and Lung
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