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anti-IGFBP2 antibody :: Mouse anti-Human IGFBP2 Antibody

Scan QR to view Datasheet Catalog #    MBS850197
Unit / Price
0.1 mg  /  $290 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IGFBP2, Antibody

 Also Known As   

Antibody to IGFBP2 Antibody

 Product Synonym Names    IBP2; IGF-BP53
 Product Gene Name   

anti-IGFBP2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    146731
 3D Structure    ModBase 3D Structure for P18065
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 Isotype    IgG1
 Clone Number    1F6F6
 Host    Mouse
 Species Reactivity    Human
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 Form/Format    Ascitic fluid containing 0.03% sodium azide.
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 Immunogen    Purified recombinant fragment of protein IGFBP2 (aa180-328) expressed in E. Coli.
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 Preparation and Storage    Store at 4 degree C, for long term storage, store at-20 degree C
 Other Notes    Small volumes of anti-IGFBP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-IGFBP2 antibody

   IGFBP2. insulin-like growth factor binding protein 2. IGFBP2 is a member of the ISGBP family which bind various IGFs. IGFBP2 is overexpressed in a wide spectrum of other cancers, including glioma, prostate cancer, synovial sarcoma, neuroblastoma, colon cancer, adrenocortical cancer, lung cancer, Wilms' tumor, and hepatoblastoma. The overexpression of IGFBP2 also correlates with the aggressiveness of some tumors. IGFBP2 activates the expression of matrix metalloprotease 2, which contributes to cell invasiveness.
 Product Categories/Family for anti-IGFBP2 antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-IGFBP2 antibody   

Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)

 Application Notes for anti-IGFBP2 antibody    WB: 1:500-1:2000
IHC: 1:200-1:1000
ELISA: 1:10000
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 Testing Data of anti-IGFBP2 antibody    Figure 1. Western blot analysis using IGFBP2 mouse mAb against truncated IGFBP2-His recombinant protein (1) and truncated IGFBP2 (aa40-328)-hIgGFc transfected CHO-K1 cell lysate (2).
anti-IGFBP2 antibody Testing Data image
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 Testing Data #2 of anti-IGFBP2 antibody    Figure 2. Immunohistochemical analysis of paraffin-embedded human lung cancer (A), recturn(B), prostate (C), colon cancer (D) showing cytoplasmic localization using IGFBP2 mouse mAb with DAB staining.
anti-IGFBP2 antibody Testing Data #2 image
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NCBI/Uniprot data below describe general gene information for IGFBP2. It may not necessarily be applicable to this product.
 NCBI GI #    55925576
 NCBI GeneID    3485
 NCBI Accession #    NP_000588.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000597.2 [Other Products]
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 UniProt Primary Accession #    P18065 [Other Products]
 UniProt Secondary Accession #    Q14619; Q9UCL3 [Other Products]
 UniProt Related Accession #    P18065 [Other Products]
 Molecular Weight    34,814 Da
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 NCBI Official Full Name    insulin-like growth factor-binding protein 2 isoform a
 NCBI Official Synonym Full Names    insulin like growth factor binding protein 2
 NCBI Official Symbol    IGFBP2 [Similar Products]
 NCBI Official Synonym Symbols   
IBP2; IGF-BP53
[Similar Products]
 NCBI Protein Information    insulin-like growth factor-binding protein 2
 UniProt Protein Name    Insulin-like growth factor-binding protein 2
 Protein Family    Insulin-like growth factor-binding protein
 UniProt Gene Name    IGFBP2 [Similar Products]
 UniProt Synonym Gene Names    BP2; IBP2; IBP-2; IGF-binding protein 2; IGFBP-2 [Similar Products]
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 NCBI Summary for IGFBP2    The protein encoded by this gene is one of six similar proteins that bind insulin-like growth factors I and II (IGF-I and IGF-II). The encoded protein can be secreted into the bloodstream, where it binds IGF-I and IGF-II with high affinity, or it can remain intracellular, interacting with many different ligands. High expression levels of this protein promote the growth of several types of tumors and may be predictive of the chances of recovery of the patient. Several transcript variants, one encoding a secreted isoform and the others encoding nonsecreted isoforms, have been found for this gene. [provided by RefSeq, Sep 2015]
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 UniProt Comments for IGFBP2    Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
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 Research Articles on IGFBP2    1. these results suggest that IGFBP2 plays an important role in promoting tumorigenesis, through estrogen and ERalpha signaling pathway.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-IGFBP2 antibodyPathways associated with anti-IGFBP2 antibody
 Reference Product  PubMed Publications
 IGF1 antibody  >43 publications with IGFBP2 and IGF1
 IGF2 antibody  >39 publications with IGFBP2 and IGF2
 FGF2 antibody  >11 publications with IGFBP2 and FGF2
 INS antibody  >4 publications with IGFBP2 and INS
 MEN1 antibody  >2 publications with IGFBP2 and MEN1
 MIIP antibody  >1 publications with IGFBP2 and MIIP
 Products by Pathway  Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Myometrial Relaxation And Contraction Pathways antibodies  Myometrial Relaxation And Contraction Pathways Diagram
 Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway antibodies  Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway Diagram
Diseases associated with anti-IGFBP2 antibodyOrgans/Tissues associated with anti-IGFBP2 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >346 publications with IGFBP2 and Neoplasms
 Carcinoma Antibodies  >97 publications with IGFBP2 and Carcinoma
 Nervous System Diseases Antibodies  >93 publications with IGFBP2 and Nervous System Diseases
 Brain Diseases Antibodies  >77 publications with IGFBP2 and Brain Diseases
 Prostatic Neoplasms Antibodies  >49 publications with IGFBP2 and Prostatic Neoplasms
 Kidney Diseases Antibodies  >49 publications with IGFBP2 and Kidney Diseases
 Adenocarcinoma Antibodies  >47 publications with IGFBP2 and Adenocarcinoma
 Breast Neoplasms Antibodies  >46 publications with IGFBP2 and Breast Neoplasms
 Cardiovascular Diseases Antibodies  >43 publications with IGFBP2 and Cardiovascular Diseases
 Liver Diseases Antibodies  >38 publications with IGFBP2 and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >585 publications with IGFBP2 and Blood
 Liver Antibodies  >179 publications with IGFBP2 and Liver
 Brain Antibodies  >141 publications with IGFBP2 and Brain
 Ovary Antibodies  >122 publications with IGFBP2 and Ovary
 Bone Antibodies  >109 publications with IGFBP2 and Bone
 Muscle Antibodies  >107 publications with IGFBP2 and Muscle
 Kidney Antibodies  >102 publications with IGFBP2 and Kidney
 Prostate Antibodies  >75 publications with IGFBP2 and Prostate
 Lung Antibodies  >67 publications with IGFBP2 and Lung
 Embryonic Tissue Antibodies  >61 publications with IGFBP2 and Embryonic Tissue
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