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anti-IKK-gamma antibody :: Rabbit anti-Human IKK-gamma (Phospho-Ser31) Antibody

Scan QR to view Datasheet Catalog #    MBS000770 anti-IKK-gamma antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IKK-gamma (Phospho-Ser31), Antibody

 Also Known As   

Rabbit IKK-gamma (Phospho-Ser31) Antibody

 Product Synonym Names    IKK-y (Phospho-Ser31)
 Product Gene Name   

anti-IKK-gamma antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: X; NC_000023.10 (153770459..153793261). Location: Xq28
 OMIM    300248
 3D Structure    ModBase 3D Structure for Q9Y6K9
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 Host    Rabbit
 Species Reactivity    Human
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 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Other Notes    Small volumes of anti-IKK-gamma antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-IKK-gamma antibody   

ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for IKK-gamma. It may not necessarily be applicable to this product.
 NCBI GI #    223671870
 NCBI GeneID    8517
 NCBI Accession #    NP_001093326.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001099856.2 [Other Products]
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 UniProt Primary Accession #    Q9Y6K9 [Other Products]
 UniProt Secondary Accession #    Q7LBY6; Q7Z7F1 [Other Products]
 UniProt Related Accession #    Q9Y6K9 [Other Products]
 Molecular Weight    48,198 Da
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 NCBI Official Full Name    NF-kappa-B essential modulator isoform b
 NCBI Official Synonym Full Names    inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
 NCBI Official Symbol    IKBKG [Similar Products]
 NCBI Official Synonym Symbols   
IP; IP1; IP2; FIP3; IPD2; NEMO; FIP-3; Fip3p; AMCBX1; ZC2HC9; IKK-gamma
[Similar Products]
 NCBI Protein Information    NF-kappa-B essential modulator; IKKG; IKKAP1; incontinentia pigmenti; IkB kinase gamma subunit; ikB kinase subunit gamma; NFkappaB essential modulator; NF-kappa-B essential modifier; I-kappa-B kinase subunit gamma; ikB kinase-associated protein 1; inhibitor of nuclear factor kappa-B kinase subunit gamma
 UniProt Protein Name    NF-kappa-B essential modulator
 UniProt Synonym Protein Names   
FIP-3; IkB kinase-associated protein 1; IKKAP1; Inhibitor of nuclear factor kappa-B kinase subunit gamma; I-kappa-B kinase subunit gamma; IKK-gamma; IKKG; IkB kinase subunit gamma; NF-kappa-B essential modifier
 UniProt Gene Name    IKBKG [Similar Products]
 UniProt Synonym Gene Names    FIP3; NEMO; NEMO; IKKAP1; I-kappa-B kinase subunit gamma; IKK-gamma; IKKG [Similar Products]
 UniProt Entry Name    NEMO_HUMAN
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 NCBI Summary for IKK-gamma    This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome. [provided by RefSeq, Aug 2011]
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 UniProt Comments for IKK-gamma    IKKG: a regulatory subunit of the IKK-signalosome complex. Interacts preferentially with IKK-beta but also able to interact with IKK-alpha, IKAP, TAX, RIP and MAP3K14/NIK. Defects are the cause of familial incontinentia pigmenti type II (IP2).

Protein type: Adaptor/scaffold; Protein kinase, regulatory subunit

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: spindle pole; cytoplasm; intracellular; IkappaB kinase complex; cytosol; nucleus; ubiquitin ligase complex

Molecular Function: protein domain specific binding; signal transducer activity; protein binding; peroxisome proliferator activated receptor binding; protein homodimerization activity; protein heterodimerization activity; metal ion binding; ubiquitin protein ligase binding

Biological Process: I-kappaB kinase/NF-kappaB cascade; establishment of vesicle localization; viral reproduction; activation of MAPK activity; apoptosis; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; T cell receptor signaling pathway; activation of NF-kappaB transcription factor; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; B cell homeostasis; positive regulation of interferon type I production; JNK cascade; inflammatory response; toll-like receptor 4 signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB cascade; transcription, DNA-dependent; MyD88-independent toll-like receptor signaling pathway; response to virus; activation of NF-kappaB-inducing kinase; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; toll-like receptor signaling pathway; innate immune response; immune response; positive regulation of transcription from RNA polymerase II promoter; toll-like receptor 9 signaling pathway; response to DNA damage stimulus

Disease: Invasive Pneumococcal Disease, Recurrent Isolated, 2; Ectodermal Dysplasia, Hypohidrotic, With Immune Deficiency; Immunodeficiency Without Anhidrotic Ectodermal Dysplasia; Immunodeficiency 33; Incontinentia Pigmenti; Ectodermal Dysplasia, Anhidrotic, With Immunodeficiency, Osteopetrosis, And Lymphedema
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 Research Articles on IKK-gamma    1. This study thus demonstrates that the Y374 or S377 residue located at the C-terminal proline-rich domain of human IKKgamma/NEMO undergoes phosphorylation upon TNF-alpha treatment or human herpesvirus 8 KvFLIP expression, respectively.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-IKK-gamma antibodyPathways associated with anti-IKK-gamma antibody
 Reference Product  PubMed Publications
 IKBKB antibody  >244 publications with IKK-gamma and IKBKB
 CHUK antibody  >15 publications with IKK-gamma and CHUK
 tax antibody  >7 publications with IKK-gamma and tax
 TANK antibody  >7 publications with IKK-gamma and TANK
 TBK1 antibody  >7 publications with IKK-gamma and TBK1
 CYLD antibody  >6 publications with IKK-gamma and CYLD
 RIPK1 antibody  >5 publications with IKK-gamma and RIPK1
 BCL10 antibody  >5 publications with IKK-gamma and BCL10
 BIRC3 antibody  >4 publications with IKK-gamma and BIRC3
 TNFAIP3 antibody  >4 publications with IKK-gamma and TNFAIP3
 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Activation Of NF-kappaB In B Cells Pathway antibodies  Activation Of NF-kappaB In B Cells Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
Diseases associated with anti-IKK-gamma antibodyOrgans/Tissues associated with anti-IKK-gamma antibody
 Disease Name  Pubmed Publications
 Incontinentia Pigmenti Antibodies  >60 publications with IKK-gamma and Incontinentia Pigmenti
 Necrosis Antibodies  >54 publications with IKK-gamma and Necrosis
 Inflammation Antibodies  >32 publications with IKK-gamma and Inflammation
 Neoplasms Antibodies  >25 publications with IKK-gamma and Neoplasms
 Carcinoma Antibodies  >7 publications with IKK-gamma and Carcinoma
 Breast Neoplasms Antibodies  >4 publications with IKK-gamma and Breast Neoplasms
 Liver Diseases Antibodies  >4 publications with IKK-gamma and Liver Diseases
 Liver Neoplasms Antibodies  >3 publications with IKK-gamma and Liver Neoplasms
 Neoplasms, Experimental Antibodies  >3 publications with IKK-gamma and Neoplasms, Experimental
 Ectodermal Dysplasia, Anhidrotic, with Immunodeficiency, Osteopetrosis, and Lymphedema Antibodies  >2 publications with IKK-gamma and Ectodermal Dysplasia, Anhidrotic, with Immunodeficiency, Osteopetrosis, and Lymphedema
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >43 publications with IKK-gamma and Blood
 Skin Antibodies  >35 publications with IKK-gamma and Skin
 Brain Antibodies  >11 publications with IKK-gamma and Brain
 Bone Antibodies  >10 publications with IKK-gamma and Bone
 Kidney Antibodies  >6 publications with IKK-gamma and Kidney
 Liver Antibodies  >5 publications with IKK-gamma and Liver
 Eye Antibodies  >4 publications with IKK-gamma and Eye
 Embryonic Tissue Antibodies  >3 publications with IKK-gamma and Embryonic Tissue
 Lung Antibodies  >3 publications with IKK-gamma and Lung
 Muscle Antibodies  >3 publications with IKK-gamma and Muscle
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