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anti-IL11RA antibody :: Rabbit anti-Human IL11RA Antibody

Scan QR to view Datasheet Catalog #    MBS004855 anti-IL11RA antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IL11RA, Antibody

 Also Known As   

Rabbit IL11RA Antibody

 Product Gene Name   

anti-IL11RA antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 9; NC_000009.11 (34652182..34661899). Location: 9p13
 OMIM    600939
 3D Structure    ModBase 3D Structure for Q14626
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 Host    Rabbit
 Species Reactivity    Human
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 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Other Notes    Small volumes of anti-IL11RA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-IL11RA antibody   

ELISA (EIA), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for IL11RA. It may not necessarily be applicable to this product.
 NCBI GI #    218505839
 NCBI GeneID    3590
 NCBI Accession #    NP_001136256.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001142784.2 [Other Products]
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 UniProt Primary Accession #    Q14626 [Other Products]
 UniProt Secondary Accession #    Q16542; Q5VZ80; Q7KYJ7 [Other Products]
 UniProt Related Accession #    Q14626 [Other Products]
 Molecular Weight    45,222 Da
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 NCBI Official Full Name    interleukin-11 receptor subunit alpha
 NCBI Official Synonym Full Names    interleukin 11 receptor, alpha
 NCBI Official Symbol    IL11RA [Similar Products]
 NCBI Official Synonym Symbols   
CRSDA
[Similar Products]
 NCBI Protein Information    interleukin-11 receptor subunit alpha; IL-11R subunit alpha; IL-11 receptor subunit alpha; interleukin-11 receptor alpha chain
 UniProt Protein Name    Interleukin-11 receptor subunit alpha
 Protein Family    Interleukin-11 receptor
 UniProt Gene Name    IL11RA [Similar Products]
 UniProt Synonym Gene Names    IL-11 receptor subunit alpha; IL-11R subunit alpha; IL-11R-alpha; IL-11RA [Similar Products]
 UniProt Entry Name    I11RA_HUMAN
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 NCBI Summary for IL11RA    Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012]
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 UniProt Comments for IL11RA    IL11RA: Receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells. Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number. Defects in IL11RA are a cause of craniosynostosis and dental anomalies (CRSDA). CRSDA is a disorder characterized by craniosynostosis, maxillary hypoplasia, and dental anomalies, including malocclusion, delayed and ectopic tooth eruption, and/or supernumerary teeth. Some patients also display minor digit anomalies, such as syndactyly and/or clinodactyly. Belongs to the type I cytokine receptor family. Type 3 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 9p13

Cellular Component: integral to plasma membrane

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; signal transducer activity; transmembrane receptor activity

Biological Process: cytokine and chemokine mediated signaling pathway; developmental process; signal transduction; embryo implantation

Disease: Craniosynostosis And Dental Anomalies
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 Research Articles on IL11RA    1. Constructed a designer cytokine Hyper IL-11 (H11), which is exclusively composed of naturally existing components. It contains the full length sIL-11Ralpha connected with the mature IL-11 protein, and acts as an agonist on cells expressing the gp130 molec
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-IL11RA antibodyPathways associated with anti-IL11RA antibody
 Reference Product  PubMed Publications
 IL11 antibody  >94 publications with IL11RA and IL11
 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Interleukin-11 Signaling Pathway antibodies  Interleukin-11 Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
Diseases associated with anti-IL11RA antibodyOrgans/Tissues associated with anti-IL11RA antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >25 publications with IL11RA and Neoplasms
 Immune System Diseases Antibodies  >8 publications with IL11RA and Immune System Diseases
 Inflammation Antibodies  >5 publications with IL11RA and Inflammation
 Necrosis Antibodies  >5 publications with IL11RA and Necrosis
 Liver Diseases Antibodies  >4 publications with IL11RA and Liver Diseases
 Vascular Diseases Antibodies  >3 publications with IL11RA and Vascular Diseases
 Liver Neoplasms Antibodies  >3 publications with IL11RA and Liver Neoplasms
 Death Antibodies  >3 publications with IL11RA and Death
 Musculoskeletal Abnormalities Antibodies  >3 publications with IL11RA and Musculoskeletal Abnormalities
 Neoplasms, Experimental Antibodies  >3 publications with IL11RA and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >24 publications with IL11RA and Bone
 Blood Antibodies  >21 publications with IL11RA and Blood
 Uterus Antibodies  >18 publications with IL11RA and Uterus
 Placenta Antibodies  >11 publications with IL11RA and Placenta
 Embryonic Tissue Antibodies  >7 publications with IL11RA and Embryonic Tissue
 Liver Antibodies  >5 publications with IL11RA and Liver
 Lung Antibodies  >5 publications with IL11RA and Lung
 Lymph Node Antibodies  >5 publications with IL11RA and Lymph Node
 Skin Antibodies  >4 publications with IL11RA and Skin
 Brain Antibodies  >4 publications with IL11RA and Brain
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