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anti-IQGAP1 antibody :: Rabbit anti-Human, mouse IQGAP1 Antibody

Scan QR to view Datasheet Catalog #    MBS003033 anti-IQGAP1 antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IQGAP1, Antibody

 Also Known As   

Rabbit IQGAP1 Antibody

 Product Gene Name   

anti-IQGAP1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 15; NC_000015.9 (90931473..91045475). Location: 15q26.1
 OMIM    603379
 3D Structure    ModBase 3D Structure for P46940
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 Host    Rabbit
 Species Reactivity    Human, mouse
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 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Other Notes    Small volumes of anti-IQGAP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-IQGAP1 antibody   

ELISA (EIA), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for IQGAP1. It may not necessarily be applicable to this product.
 NCBI GI #    4506787
 NCBI GeneID    8826
 NCBI Accession #    NP_003861.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_003870.3 [Other Products]
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 UniProt Primary Accession #    P46940 [Other Products]
 UniProt Secondary Accession #    A7MBM3 [Other Products]
 UniProt Related Accession #    P46940 [Other Products]
 Molecular Weight    189,252 Da
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 NCBI Official Full Name    ras GTPase-activating-like protein IQGAP1
 NCBI Official Synonym Full Names    IQ motif containing GTPase activating protein 1
 NCBI Official Symbol    IQGAP1 [Similar Products]
 NCBI Official Synonym Symbols   
SAR1; p195; HUMORFA01
[Similar Products]
 NCBI Protein Information    ras GTPase-activating-like protein IQGAP1; RasGAP-like with IQ motifs
 UniProt Protein Name    Ras GTPase-activating-like protein IQGAP1
 UniProt Synonym Protein Names   
p195
 Protein Family    Ras GTPase-activating-like protein
 UniProt Gene Name    IQGAP1 [Similar Products]
 UniProt Synonym Gene Names    KIAA0051 [Similar Products]
 UniProt Entry Name    IQGA1_HUMAN
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 NCBI Summary for IQGAP1    This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines. [provided by RefSeq, Jul 2008]
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 UniProt Comments for IQGAP1    IQGAP1: Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth. Interacts with CDC42; the interaction is demonstrated with IQGAP1 in GTP-bound and in nucleotide-free state. Interacts with RAC1. Does not interact with RHOA. Interacts with TSG101. Interacts with PAK6. Expressed in the placenta, lung, and kidney. A lower level expression is seen in the heart, liver, skeletal muscle and pancreas.

Protein type: GAPs, Ras; GAPs; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 15q26.1

Cellular Component: microtubule; neuron projection; focal adhesion; leading edge; actin filament; actin cytoskeleton; microtubule cytoskeleton; nucleoplasm; extrinsic to internal side of plasma membrane; growth cone; axon; cytoplasm; plasma membrane; midbody; cell junction; lateral plasma membrane

Molecular Function: calmodulin binding; protein serine/threonine kinase activator activity; protein binding; phosphatidylinositol-3,4,5-triphosphate binding; Rac GTPase binding; protein complex binding; calcium ion binding; protein phosphatase binding; protein kinase binding; GTPase activator activity; GTPase inhibitor activity

Biological Process: epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; small GTPase mediated signal transduction; positive regulation of protein kinase activity; negative regulation of dephosphorylation; negative regulation of catalytic activity; energy reserve metabolic process; platelet-derived growth factor receptor signaling pathway; signal transduction; regulation of insulin secretion; regulation of cytokine production; positive regulation of GTPase activity
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 Research Articles on IQGAP1    1. RhoC stimulates the proliferation of gastric cancer cells through recruiting IQGAP1 as an effector.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-IQGAP1 antibodyPathways associated with anti-IQGAP1 antibody
 Reference Product  PubMed Publications
 CDC42 antibody  >108 publications with IQGAP1 and CDC42
 RAC1 antibody  >94 publications with IQGAP1 and RAC1
 CTNNB1 antibody  >53 publications with IQGAP1 and CTNNB1
 APC antibody  >12 publications with IQGAP1 and APC
 S100B antibody  >3 publications with IQGAP1 and S100B
 NPHS1 antibody  >2 publications with IQGAP1 and NPHS1
 MEN1 antibody  >1 publications with IQGAP1 and MEN1
 CYBB antibody  >1 publications with IQGAP1 and CYBB
 CLIC5 antibody  >1 publications with IQGAP1 and CLIC5
 AKAP5 antibody  >1 publications with IQGAP1 and AKAP5
 Products by Pathway  Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram
 CDC42 Signaling Events Pathway antibodies  CDC42 Signaling Events Pathway Diagram
 Cell-Cell Communication Pathway antibodies  Cell-Cell Communication Pathway Diagram
 E-cadherin Signaling In The Nascent Adherens Junction Pathway antibodies  E-cadherin Signaling In The Nascent Adherens Junction Pathway Diagram
 ErbB1 Downstream Signaling Pathway antibodies  ErbB1 Downstream Signaling Pathway Diagram
 G13 Signaling Pathway antibodies  G13 Signaling Pathway Diagram
 Integration Of Energy Metabolism Pathway antibodies  Integration Of Energy Metabolism Pathway Diagram
 Lissencephaly Gene (LIS1) In Neuronal Migration And Development Pathway antibodies  Lissencephaly Gene (LIS1) In Neuronal Migration And Development Pathway Diagram
Diseases associated with anti-IQGAP1 antibodyOrgans/Tissues associated with anti-IQGAP1 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >68 publications with IQGAP1 and Neoplasms
 Breast Neoplasms Antibodies  >11 publications with IQGAP1 and Breast Neoplasms
 Brain Diseases Antibodies  >9 publications with IQGAP1 and Brain Diseases
 Nervous System Diseases Antibodies  >9 publications with IQGAP1 and Nervous System Diseases
 Liver Diseases Antibodies  >8 publications with IQGAP1 and Liver Diseases
 Liver Neoplasms Antibodies  >8 publications with IQGAP1 and Liver Neoplasms
 Inflammation Antibodies  >7 publications with IQGAP1 and Inflammation
 Carcinoma, Hepatocellular Antibodies  >6 publications with IQGAP1 and Carcinoma, Hepatocellular
 Cell Transformation, Neoplastic Antibodies  >6 publications with IQGAP1 and Cell Transformation, Neoplastic
 Heart Diseases Antibodies  >3 publications with IQGAP1 and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >21 publications with IQGAP1 and Blood
 Vascular Antibodies  >20 publications with IQGAP1 and Vascular
 Brain Antibodies  >20 publications with IQGAP1 and Brain
 Liver Antibodies  >15 publications with IQGAP1 and Liver
 Lung Antibodies  >14 publications with IQGAP1 and Lung
 Stomach Antibodies  >12 publications with IQGAP1 and Stomach
 Muscle Antibodies  >11 publications with IQGAP1 and Muscle
 Kidney Antibodies  >10 publications with IQGAP1 and Kidney
 Embryonic Tissue Antibodies  >9 publications with IQGAP1 and Embryonic Tissue
 Intestine Antibodies  >5 publications with IQGAP1 and Intestine
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