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anti-IR antibody :: Rabbit IR Antibody

Scan QR to view Datasheet Catalog #    MBS852561
Testing Data
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
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 Product Name   

IR, Antibody

★Popular Item★
 Also Known As   

IR (Phospho-Thr1375) Antibody

 Product Synonym Names    CD220 antigen; EC; insulin receptor; IR; kinase InsR
 Product Gene Name   

anti-IR antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    610549
 3D Structure    ModBase 3D Structure for P06213
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 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    INSR (Phospho-Thr1375) antibody detects endogenous levels of INSR only when phosphorylated at threonine 1375.
 Purity/Purification    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation
 Form/Format    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Reactivity Note    Human (Identities = 100%, Positives = 100%); Mouse (Identities = 92%, Positives = 100%); Rat (Identities = 92%, Positives = 100%)
 Immunogen    The antiserum was produced against synthesized phosphopeptide derived from human INSR around the phosphorylation site of threonine 1375 (I-L-TP-L-P).
 All Sites    Human: Thr1375; Mouse: Thr1365; Rat: Thr1376
 Pathway    Phospho-specific
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 Preparation and Storage    Store at -20 degree C for 1 year
 Other Notes    Small volumes of anti-IR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-IR antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-IR antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-IR antibody    WB: 1:500~1:1000, ELISA: 1:5000
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 Testing Data of anti-IR antibody    Western blot analysis of extracts from HepG2 cells, using INSR (Phospho-Thr1375) antibody.
anti-IR antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for IR. It may not necessarily be applicable to this product.
 NCBI GI #    119395736
 NCBI GeneID    3643
 NCBI Accession #    NP_000199.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000208.2 [Other Products]
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 UniProt Primary Accession #    P06213 [Other Products]
 UniProt Secondary Accession #    Q17RW0; Q59H98; Q9UCB7; Q9UCB8; Q9UCB9 [Other Products]
 UniProt Related Accession #    P06213 [Other Products]
 Molecular Weight    155,146 Da
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 NCBI Official Full Name    insulin receptor isoform Long preproprotein
 NCBI Official Synonym Full Names    insulin receptor
 NCBI Official Symbol    INSR [Similar Products]
 NCBI Official Synonym Symbols   
HHF5; CD220
[Similar Products]
 NCBI Protein Information    insulin receptor; IR
 UniProt Protein Name    Insulin receptor
 UniProt Synonym Protein Names   
CD_antigen: CD220Cleaved into the following 2 chains:Insulin receptor subunit alpha; Insulin receptor subunit beta
 Protein Family    Irditoxin
 UniProt Gene Name    INSR [Similar Products]
 UniProt Synonym Gene Names    IR [Similar Products]
 UniProt Entry Name    INSR_HUMAN
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 NCBI Summary for IR    After removal of the precursor signal peptide, the insulin receptor precursor is post-translationally cleaved into two chains (alpha and beta) that are covalently linked. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for IR    INSR: a receptor tyrosine kinase that mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosines residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT pathway, which is responsible for most of the metabolic actions of insulin, and the Ras-MAPK pathway, which regulates expression of some genes and cooperates with the PI3K pathway to control cell growth and differentiation. In addition to binding insulin, the insulin receptor can bind insulin-like growth factors (IGFI and IGFII). The holoenzyme is cleaved into two chains, the alpha and beta subunits. The active complex is a tetramer containing 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains constitute the ligand- binding domain, while the beta chains carry the kinase domain. Interacts with SORBS1 but dissociates from it following insulin stimulation. Familial mutations associated with insulin resistant diabetes, acanthosis nigricans, pineal hyperplasia, and polycystic ovary syndrome. SNP variants may be associated with polycystic ovary syndrome, atypical migraine and diabetic hyperlipidemia. Mutations also cause leprechaunism, a severe insulin resistance syndrome causing growth retardation and death in early infancy. Two isoforms of the human protein are produced by alternative splicing. The Short isoform has a higher affinity for insulin than the longer. Isoform Long and isoform Short are predominantly expressed in tissue targets of insulin metabolic effects: liver, adipose tissue and skeletal muscle but are also expressed in the peripheral nerve, kidney, pulmonary alveoli, pancreatic acini, placenta vascular endothelium, fibroblasts, monocytes, granulocytes, erythrocytes and skin. Isoform Short is preferentially expressed in fetal cells such as fetal fibroblasts, muscle, liver and kidney. Found as a hybrid receptor with IGF1R in muscle, heart, kidney, adipose tissue, skeletal muscle, hepatoma, fibroblasts, spleen and placenta. Overexpressed in several tumors, including breast, colon, lung, ovary, and thyroid carcinomas.

Protein type: Protein kinase, tyrosine (receptor); EC; Kinase, protein; Membrane protein, integral; Protein kinase, TK; TK group; InsR family

Chromosomal Location of Human Ortholog: 19p13.3-p13.2

Cellular Component: membrane; intracellular membrane-bound organelle; integral to plasma membrane; plasma membrane; endosome membrane; caveola; receptor complex

Molecular Function: GTP binding; PTB domain binding; receptor signaling protein tyrosine kinase activity; insulin-like growth factor II binding; insulin binding; insulin-like growth factor receptor binding; protein binding; insulin-like growth factor I binding; insulin receptor substrate binding; protein-tyrosine kinase activity; phosphoinositide 3-kinase binding; ATP binding; insulin receptor activity

Biological Process: heart morphogenesis; epidermis development; positive regulation of nitric oxide biosynthetic process; peptidyl-tyrosine phosphorylation; activation of MAPK activity; protein amino acid autophosphorylation; regulation of embryonic development; positive regulation of glycogen biosynthetic process; exocrine pancreas development; glucose homeostasis; positive regulation of glucose import; positive regulation of MAPKKK cascade; regulation of transcription, DNA-dependent; male sex determination; positive regulation of cell proliferation; protein heterotetramerization; positive regulation of developmental growth; positive regulation of mitosis; activation of protein kinase B; G-protein coupled receptor protein signaling pathway; positive regulation of protein kinase B signaling cascade; cellular response to insulin stimulus; positive regulation of glycolysis; carbohydrate metabolic process; insulin receptor signaling pathway; activation of protein kinase activity; positive regulation of protein amino acid phosphorylation; positive regulation of DNA replication; positive regulation of cell migration; transformation of host cell by virus

Disease: Diabetes Mellitus, Insulin-resistant, With Acanthosis Nigricans; Hyperinsulinemic Hypoglycemia, Familial, 5; Pineal Hyperplasia, Insulin-resistant Diabetes Mellitus, And Somatic Abnormalities; Donohue Syndrome
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Product References and Citations for anti-IR antibody

   Ebina Y., Cell 40:747-758(1985).
Ullrich A., Nature 313:756-761(1985).
Seino S., Diabetes 39:123-128(1990).
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 Research Articles on IR    1. Data indicate that changes in tyrosine phosphorylation of insulin receptor (InsR) are associated with insulin resistance (IR) in patients with gestational diabetes mellitus (GDM)
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-IR antibodyPathways associated with anti-IR antibody
 Reference Product  PubMed Publications
 IRS1 antibody  >55 publications with IR and IRS1
 IGF1 antibody  >34 publications with IR and IGF1
 INS antibody  >29 publications with IR and INS
 IRS2 antibody  >25 publications with IR and IRS2
 PIK3R1 antibody  >7 publications with IR and PIK3R1
 PTPN1 antibody  >4 publications with IR and PTPN1
 SHC1 antibody  >3 publications with IR and SHC1
 GRB10 antibody  >1 publications with IR and GRB10
 Products by Pathway  Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 DNA Damage Response (only ATM Dependent) Pathway antibodies  DNA Damage Response (only ATM Dependent) Pathway Diagram
 FoxO Signaling Pathway antibodies  FoxO Signaling Pathway Diagram
Diseases associated with anti-IR antibodyOrgans/Tissues associated with anti-IR antibody
 Disease Name  Pubmed Publications
 Insulin Resistance Antibodies  >168 publications with IR and Insulin Resistance
 Hyperinsulinism Antibodies  >103 publications with IR and Hyperinsulinism
 Hyperglycemia Antibodies  >33 publications with IR and Hyperglycemia
 Nervous System Diseases Antibodies  >25 publications with IR and Nervous System Diseases
 Diabetes Mellitus, Experimental Antibodies  >19 publications with IR and Diabetes Mellitus, Experimental
 Hypertension Antibodies  >19 publications with IR and Hypertension
 Breast Neoplasms Antibodies  >18 publications with IR and Breast Neoplasms
 Brain Diseases Antibodies  >17 publications with IR and Brain Diseases
 Donohue Syndrome Antibodies  >14 publications with IR and Donohue Syndrome
 Inflammation Antibodies  >13 publications with IR and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >126 publications with IR and Blood
 Muscle Antibodies  >70 publications with IR and Muscle
 Liver Antibodies  >62 publications with IR and Liver
 Brain Antibodies  >55 publications with IR and Brain
 Ovary Antibodies  >37 publications with IR and Ovary
 Adipose Tissue Antibodies  >27 publications with IR and Adipose Tissue
 Connective Tissue Antibodies  >21 publications with IR and Connective Tissue
 Pancreas Antibodies  >20 publications with IR and Pancreas
 Bone Antibodies  >15 publications with IR and Bone
 Vascular Antibodies  >14 publications with IR and Vascular
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