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anti-IRF2 antibody :: Rabbit IRF2 Antibody

Scan QR to view Datasheet Catalog #    MBS003857 anti-IRF2 antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IRF2, Antibody

 Also Known As   

Rabbit IRF2 Antibody

 Product Gene Name   

anti-IRF2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 4; NC_000004.11 (185308876..185395726, complement). Location: 4q34.1-q35.1
 OMIM    147576
 3D Structure    ModBase 3D Structure for P14316
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 Host    Rabbit
 Species Reactivity    Human, mouse, rat
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 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Other Notes    Small volumes of anti-IRF2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-IRF2 antibody   

ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for IRF2. It may not necessarily be applicable to this product.
 NCBI GI #    153082752
 NCBI GeneID    3660
 NCBI Accession #    NP_002190.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_002199.3 [Other Products]
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 UniProt Primary Accession #    P14316 [Other Products]
 UniProt Secondary Accession #    Q6IAS7; Q96B99; D6RCK5; H0Y8S3 [Other Products]
 UniProt Related Accession #    P14316 [Other Products]
 Molecular Weight    39,354 Da
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 NCBI Official Full Name    interferon regulatory factor 2
 NCBI Official Synonym Full Names    interferon regulatory factor 2
 NCBI Official Symbol    IRF2 [Similar Products]
 NCBI Official Synonym Symbols   
IRF-2
[Similar Products]
 NCBI Protein Information    interferon regulatory factor 2
 UniProt Protein Name    Interferon regulatory factor 2
 Protein Family    Interferon regulatory factor
 UniProt Gene Name    IRF2 [Similar Products]
 UniProt Synonym Gene Names    IRF-2 [Similar Products]
 UniProt Entry Name    IRF2_HUMAN
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 NCBI Summary for IRF2    IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4. [provided by RefSeq, Jul 2008]
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 UniProt Comments for IRF2    IRF2: Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation. Interacts with BRD7, IRF2BP1 and IRF2BP2. Interacts with CREBBP in growing cells; the interaction acetylates IRF2 and regulates IRF2-dependent H4 promoter activity. By viruses and IFN. Expressed throughout the epithelium of the colon. Also expressed in lamina propria. Belongs to the IRF family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 4q34.1-q35.1

Cellular Component: nucleoplasm; focal adhesion; cytoplasm; cytosol

Molecular Function: protein binding; DNA binding; transcription factor activity

Biological Process: cell proliferation; regulation of transcription, DNA-dependent; transcription, DNA-dependent; cytokine and chemokine mediated signaling pathway; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; blood coagulation
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 Research Articles on IRF2    1. IRF2 overexpression protects against I/R injury by decreasing IRF1-dependent injury and may represent a novel therapeutic strategy.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-IRF2 antibodyPathways associated with anti-IRF2 antibody
 Reference Product  PubMed Publications
 STAT1 antibody  >30 publications with IRF2 and STAT1
 IRF8 antibody  >7 publications with IRF2 and IRF8
 EP300 antibody  >3 publications with IRF2 and EP300
 RELA antibody  >1 publications with IRF2 and RELA
 NFKB1 antibody  >1 publications with IRF2 and NFKB1
 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Factors Involved In Megakaryocyte Development And Platelet Production Pathway antibodies  Factors Involved In Megakaryocyte Development And Platelet Production Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Interferon Signaling Pathway antibodies  Interferon Signaling Pathway Diagram
 Interferon Alpha/beta Signaling Pathway antibodies  Interferon Alpha/beta Signaling Pathway Diagram
 Interferon Gamma Signaling Pathway antibodies  Interferon Gamma Signaling Pathway Diagram
 RIG-I/MDA5 Mediated Induction Of IFN-alpha/beta Pathways antibodies  RIG-I/MDA5 Mediated Induction Of IFN-alpha/beta Pathways Diagram
Diseases associated with anti-IRF2 antibodyOrgans/Tissues associated with anti-IRF2 antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >13 publications with IRF2 and Necrosis
 Cell Transformation, Neoplastic Antibodies  >10 publications with IRF2 and Cell Transformation, Neoplastic
 Death Antibodies  >10 publications with IRF2 and Death
 Liver Diseases Antibodies  >10 publications with IRF2 and Liver Diseases
 Inflammation Antibodies  >10 publications with IRF2 and Inflammation
 Hepatitis Antibodies  >8 publications with IRF2 and Hepatitis
 Nervous System Diseases Antibodies  >8 publications with IRF2 and Nervous System Diseases
 Breast Neoplasms Antibodies  >5 publications with IRF2 and Breast Neoplasms
 Liver Neoplasms Antibodies  >4 publications with IRF2 and Liver Neoplasms
 Brain Diseases Antibodies  >4 publications with IRF2 and Brain Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >48 publications with IRF2 and Blood
 Bone Antibodies  >20 publications with IRF2 and Bone
 Bone Marrow Antibodies  >19 publications with IRF2 and Bone Marrow
 Liver Antibodies  >15 publications with IRF2 and Liver
 Skin Antibodies  >12 publications with IRF2 and Skin
 Lung Antibodies  >11 publications with IRF2 and Lung
 Brain Antibodies  >8 publications with IRF2 and Brain
 Uterus Antibodies  >7 publications with IRF2 and Uterus
 Spleen Antibodies  >7 publications with IRF2 and Spleen
 Heart Antibodies  >4 publications with IRF2 and Heart
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