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anti-IRS-2 (pS731) antibody :: Rabbit IRS-2 (pS731) Antibody

Scan QR to view Datasheet Catalog #    MBS462062
Testing Data
Unit / Price
0.1 mg  /  $285 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IRS-2 (pS731) (IRS-2 (pS731)), Antibody

★Popular Item★
 Also Known As   

Rabbit anti Phospho- IRS-2 (pSer 731) antibody

 Product Synonym Names    Rabbit anti-IRS-2 (p Ser731); Anti-phospho-IRS-2 (pSer731); Insulin-receptor substrate 2 (IRS-2).
 Product Gene Name   

anti-IRS-2 (pS731) antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 13; NC_000013.10 (110406184..110438914, complement). Location: 13q34
 OMIM    600797
 3D Structure    ModBase 3D Structure for Q96RG4
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 Host    Rabbit
 Species Reactivity    Human, Rat, Mouse
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 Specificity    This antibody recognizes ~180 kDa of human IRS-2 (pSer731). It also reacts with mouse and rat. The other species are not tested.
 Purity/Purification    The Rabbit IgG is purified by Site-specific Epitope Affinity Purification.
 Form/Format    This affinity purified antibody is supplied in sterile Tris-buffered saline (pH7.2) containing antibody stabilizer
 Concentration    Size: 100 ug/200 ul (lot specific)
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 Antigen Preparation    A synthetic peptide corresponding to the epitope ASSPA with a single phosphorylation site Ser 731 of human IRS-2.
 Positive Control    3T3 cell lysate
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 Preparation and Storage    The antibodies are stable for 12 months from date of receipt when stored at -20 degree C to -70 degree C. The antibodies can be stored at 2 degree C-8 degree C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
 Other Notes    Small volumes of anti-IRS-2 (pS731) antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-IRS-2 (pS731) antibody

   Insulin Receptor Substrate-2 (IRS-2), a 180kDa cytoplasmic docking protein, is one of the major endogenous substrates of the insulin receptor kinase. The insulin receptor mediates insulin action through the phosphorylation of substrate proteins. The major substrates of the insulin receptor kinase are the insulin receptor substrate (IRS) family of proteins, IRS 1, IRS 2, IRS 3, and IRS 4. IRS 2, a signaling molecule that mediates effects of insulin, Insulin-like growth factor 1 and other cytokines by acting as a molecular adaptor between diverse receptor kinases and downstream effectors. IRS proteins contain more than 70 potential Ser / Thr phosphorylation sites for kinases like PKA (cAMP-dependent protein kinase), PKC, and MAPK. The phosphorylation of Ser / Thr residues of IRS proteins has a dual function, serving either for a positive or negative modulation of insulin signal transduction.
 Applications Tested/Suitable for anti-IRS-2 (pS731) antibody   

ELISA, Western Blot, Immunohistochemistry

 Application Notes for anti-IRS-2 (pS731) antibody    Western Blot: 0.1-1 ug/ml
ELISA: 0.01-0.1 ug/ml
Immunoprecipitation: 2-5 ug/ml
Immunohistochemistry: 0.5-2 ug/ml
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 Testing Data of anti-IRS-2 (pS731) antibody    anti-IRS-2 (pS731) antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for IRS-2 (pS731). It may not necessarily be applicable to this product.
 NCBI GI #    38683860
 NCBI GeneID    8660
 NCBI Accession #    NP_003740.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_003749.2 [Other Products]
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 UniProt Primary Accession #    Q96RG4 [Other Products]
 UniProt Related Accession #    Q8TF73; Q96RG4; Q96RG5; Q9P084; Q9UP29; Q9Y4H2 [Other Products]
 Molecular Weight    180 kDa
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 NCBI Official Full Name    insulin receptor substrate 2
 NCBI Official Synonym Full Names    insulin receptor substrate 2
 NCBI Official Symbol    IRS2 [Similar Products]
 NCBI Official Synonym Symbols   
IRS-2
[Similar Products]
 NCBI Protein Information    insulin receptor substrate 2; OTTHUMP00000018696
 UniProt Protein Name    Insulin receptor substrate 2 insertion mutant
 UniProt Gene Name    IRS2 [Similar Products]
 UniProt Entry Name    Q96RG4_HUMAN
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 NCBI Summary for IRS-2 (pS731)    This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment. [provided by RefSeq]
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 UniProt Comments for IRS-2 (pS731)    Sequence similarities: Contains 1 PH domain. RuleBase RU003350
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Product References and Citations for anti-IRS-2 (pS731) antibody

   Li, Y. et al. (2004) J. Biol. Chem. 279, 45304-45307.
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 Research Articles on IRS-2 (pS731)    1. In chronic hepatitis B patients the expression and tyrosine phosphorylation of IRS-2 in hepatic tissue were significantly decreased.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-IRS-2 (pS731) antibodyPathways associated with anti-IRS-2 (pS731) antibody
 Reference Product  PubMed Publications
 IGF1R antibody  >75 publications with IRS-2 (pS731) and IGF1R
 GRB2 antibody  >40 publications with IRS-2 (pS731) and GRB2
 JAK2 antibody  >34 publications with IRS-2 (pS731) and JAK2
 SHC1 antibody  >24 publications with IRS-2 (pS731) and SHC1
 JAK1 antibody  >14 publications with IRS-2 (pS731) and JAK1
 SOCS3 antibody  >14 publications with IRS-2 (pS731) and SOCS3
 INSR antibody  >14 publications with IRS-2 (pS731) and INSR
 JAK3 antibody  >13 publications with IRS-2 (pS731) and JAK3
 PTPN6 antibody  >11 publications with IRS-2 (pS731) and PTPN6
 PTPN11 antibody  >10 publications with IRS-2 (pS731) and PTPN11
 Products by Pathway  Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Downstream Signaling Of Activated FGFR Pathway antibodies  Downstream Signaling Of Activated FGFR Pathway Diagram
 EPO Receptor Signaling Pathway antibodies  EPO Receptor Signaling Pathway Diagram
 EPO Signaling Pathway antibodies  EPO Signaling Pathway Diagram
 IGF1 Pathway antibodies  IGF1 Pathway Diagram
Diseases associated with anti-IRS-2 (pS731) antibodyOrgans/Tissues associated with anti-IRS-2 (pS731) antibody
 Disease Name  Pubmed Publications
 Insulin Resistance Antibodies  >313 publications with IRS-2 (pS731) and Insulin Resistance
 Hyperinsulinism Antibodies  >212 publications with IRS-2 (pS731) and Hyperinsulinism
 Neoplasms Antibodies  >121 publications with IRS-2 (pS731) and Neoplasms
 Diabetes Mellitus, Type 2 Antibodies  >104 publications with IRS-2 (pS731) and Diabetes Mellitus, Type 2
 Disease Models, Animal Antibodies  >62 publications with IRS-2 (pS731) and Disease Models, Animal
 Hyperglycemia Antibodies  >61 publications with IRS-2 (pS731) and Hyperglycemia
 Liver Diseases Antibodies  >45 publications with IRS-2 (pS731) and Liver Diseases
 Fatty Liver Antibodies  >40 publications with IRS-2 (pS731) and Fatty Liver
 Glucose Intolerance Antibodies  >33 publications with IRS-2 (pS731) and Glucose Intolerance
 Necrosis Antibodies  >27 publications with IRS-2 (pS731) and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >187 publications with IRS-2 (pS731) and Blood
 Muscle Antibodies  >166 publications with IRS-2 (pS731) and Muscle
 Pancreas Antibodies  >131 publications with IRS-2 (pS731) and Pancreas
 Adipose Tissue Antibodies  >77 publications with IRS-2 (pS731) and Adipose Tissue
 Connective Tissue Antibodies  >64 publications with IRS-2 (pS731) and Connective Tissue
 Brain Antibodies  >51 publications with IRS-2 (pS731) and Brain
 Heart Antibodies  >30 publications with IRS-2 (pS731) and Heart
 Kidney Antibodies  >30 publications with IRS-2 (pS731) and Kidney
 Ovary Antibodies  >23 publications with IRS-2 (pS731) and Ovary
 Bone Antibodies  >16 publications with IRS-2 (pS731) and Bone
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