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anti-IRS1 antibody :: IRS1-S636 Antibody

Scan QR to view Datasheet Catalog #    MBS128253
Western Blot (WB)
Unit / Price
0.05 mL  /  $265 +1 FREE 8GB USB
0.1 mL  /  $380 +1 FREE 8GB USB
0.2 mL  /  $555 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IRS1-S636, Antibody

★Popular Item★
 Also Known As   

Phospho-IRS1-S636 Polyclonal Antibody

 Product Synonym Names    Phospho-IRS1-S636: HIRS-1
 Product Gene Name   

anti-IRS1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    phenotype 147545
 3D Structure    ModBase 3D Structure for P35568
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 Isotype    IgG
 Species Reactivity    Human, Mouse.
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 Purity/Purification    Affinity Purification
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 Source    Rabbit
 Calculated MW    131 kDa
 Observed MW    170kDa
 Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Immunogen    A phospho specific peptide corresponding to residues surrounding S636 of human IRS1
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 Preparation and Storage    Store at -20C. Avoid freeze / thaw cycles.
 Other Notes    Small volumes of anti-IRS1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-IRS1 antibody

   This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance.
 Product Categories/Family for anti-IRS1 antibody    Phosphorylation
 Applications Tested/Suitable for anti-IRS1 antibody   

Western Blot (WB)

 Application Notes for anti-IRS1 antibody    WB 1:1000-1:3000
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 Western Blot (WB) of anti-IRS1 antibody    Western blot analysis of extracts from 3T3 cells, using Phospho-IRS1-S636 antibody.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% BSA.
anti-IRS1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for IRS1. It may not necessarily be applicable to this product.
 NCBI GI #    547738
 NCBI GeneID    3667
 NCBI Accession #    P35568.1 [Other Products]
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 UniProt Primary Accession #    P35568 [Other Products]
 UniProt Related Accession #    P35568 [Other Products]
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 NCBI Official Full Name    Insulin receptor substrate 1
 NCBI Official Synonym Full Names    insulin receptor substrate 1
 NCBI Official Symbol    IRS1 [Similar Products]
 NCBI Official Synonym Symbols   
HIRS-1
[Similar Products]
 NCBI Protein Information    insulin receptor substrate 1; IRS-1
 UniProt Protein Name    Insulin receptor substrate 1
 Protein Family    Isoleucine--tRNA ligase
 UniProt Gene Name    IRS1 [Similar Products]
 UniProt Synonym Gene Names    IRS-1 [Similar Products]
 UniProt Entry Name    IRS1_HUMAN
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 NCBI Summary for IRS1    This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. [provided by RefSeq, Nov 2009]
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 UniProt Comments for IRS1    IRS1: an adaptor protein that is one of the major substrates of the insulin receptor kinase. Contains multiple tyrosine phosphorylation motifs that serve as docking sites for SH2-domain-containing proteins including phosphatidylinositol 3-kinase p85 subunit and GRB-2. Phosphorylated on ser/thr residues by kinases including JNK and IKK.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 2q36

Cellular Component: intracellular membrane-bound organelle; cytoplasm; plasma membrane; caveola; cytosol; nucleus

Molecular Function: insulin-like growth factor receptor binding; protein binding; signal transducer activity; protein kinase C binding; phosphoinositide 3-kinase binding; SH2 domain binding; transmembrane receptor protein tyrosine kinase adaptor protein activity; insulin receptor binding

Biological Process: response to peptide hormone stimulus; phosphoinositide 3-kinase cascade; nerve growth factor receptor signaling pathway; positive regulation of glycogen biosynthetic process; negative regulation of insulin receptor signaling pathway; glucose homeostasis; signal transduction; negative regulation of insulin secretion; response to insulin stimulus; positive regulation of glucose import; mammary gland development; positive regulation of mesenchymal cell proliferation; positive regulation of cell proliferation; protein kinase B signaling cascade; epidermal growth factor receptor signaling pathway; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; positive regulation of phosphoinositide 3-kinase activity; positive regulation of fatty acid beta-oxidation; cellular response to insulin stimulus; insulin-like growth factor receptor signaling pathway; regulation of gene expression; insulin receptor signaling pathway; innate immune response; positive regulation of insulin receptor signaling pathway; lipid catabolic process; positive regulation of cell migration

Disease: Diabetes Mellitus, Noninsulin-dependent
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 Research Articles on IRS1    1. The Arg972 IRS1 polymorphism is an independent risk factor for AD and the A allele has a gene dosage effect on AD severity in Han Chinese.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-IRS1 antibodyPathways associated with anti-IRS1 antibody
 Reference Product  PubMed Publications
 IGF1R antibody  >246 publications with IRS1 and IGF1R
 GRB2 antibody  >138 publications with IRS1 and GRB2
 JAK2 antibody  >63 publications with IRS1 and JAK2
 INSR antibody  >57 publications with IRS1 and INSR
 PTPN11 antibody  >42 publications with IRS1 and PTPN11
 JAK1 antibody  >26 publications with IRS1 and JAK1
 MAPK8 antibody  >23 publications with IRS1 and MAPK8
 PIK3R1 antibody  >12 publications with IRS1 and PIK3R1
 PIK3CA antibody  >6 publications with IRS1 and PIK3CA
 Products by Pathway  Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
Diseases associated with anti-IRS1 antibodyOrgans/Tissues associated with anti-IRS1 antibody
 Disease Name  Pubmed Publications
 Insulin Resistance Antibodies  >1250 publications with IRS1 and Insulin Resistance
 Hyperinsulinism Antibodies  >852 publications with IRS1 and Hyperinsulinism
 Diabetes Mellitus Antibodies  >503 publications with IRS1 and Diabetes Mellitus
 Obesity Antibodies  >424 publications with IRS1 and Obesity
 Diabetes Mellitus, Type 2 Antibodies  >343 publications with IRS1 and Diabetes Mellitus, Type 2
 Disease Models, Animal Antibodies  >205 publications with IRS1 and Disease Models, Animal
 Hyperglycemia Antibodies  >185 publications with IRS1 and Hyperglycemia
 Necrosis Antibodies  >176 publications with IRS1 and Necrosis
 Liver Diseases Antibodies  >136 publications with IRS1 and Liver Diseases
 Inflammation Antibodies  >135 publications with IRS1 and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >871 publications with IRS1 and Muscle
 Liver Antibodies  >490 publications with IRS1 and Liver
 Connective Tissue Antibodies  >247 publications with IRS1 and Connective Tissue
 Pancreas Antibodies  >146 publications with IRS1 and Pancreas
 Heart Antibodies  >138 publications with IRS1 and Heart
 Brain Antibodies  >125 publications with IRS1 and Brain
 Ovary Antibodies  >113 publications with IRS1 and Ovary
 Kidney Antibodies  >96 publications with IRS1 and Kidney
 Nerve Antibodies  >46 publications with IRS1 and Nerve
 Bone Antibodies  >46 publications with IRS1 and Bone
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