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anti-IKBA antibody :: IkappaB-alpha Antibody

Scan QR to view Datasheet Catalog #    MBS857349
Immunohistochemistry (IHC)
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
0.05 mg  /  $225 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IkappaB-alpha (IKBA), Antibody

 Also Known As   

IkappaB-alpha (Phospho-Tyr42) Antibody

 Product Synonym Names    I-kappa-B-alpha; IkappaBalpha; MAD3; Major histocompatibility complex enhancer-binding protein MAD3; NF-kappaB inhibitor alpha; NFKBI; NFKBIA; RL/IF-1
 Product Gene Name   

anti-IKBA antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    164008
 3D Structure    ModBase 3D Structure for P25963
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 Species Reactivity    Human, Mouse, Rat
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 Specificity    IkappaB-alpha (phospho-Tyr42) antibody detects endogenous levels of IkappaB-alpha only when phosphorylated at tyrosine 42.
 Purity/Purification    Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatogramphy using non-phosphopeptide corresponding to the phosphorylation site.
 Form/Format    In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Immunogen    The antiserum was produced against synthesized phosphopeptide derived from human IkappaB-alpha around the phosphorylation site of tyrosine 42 (E-E-YP-E-Q).
 All Sites    Human: Tyr42
Mouse: Tyr42
Rat: Tyr42
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 Preparation and Storage    Store at-20 degree C for 1 year
 Other Notes    Small volumes of anti-IKBA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-IKBA antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-IKBA antibody   

Immunohistochemistry (IHC)

 Application Notes for anti-IKBA antibody    IHC: 1:50-1:100
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 Immunohistochemistry (IHC) of anti-IKBA antibody    P-Peptide-+ Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using IkappaB-alpha (phospho-Tyr42) antibody.
anti-IKBA antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for IKBA. It may not necessarily be applicable to this product.
 NCBI GI #    10092619
 NCBI GeneID    4792
 NCBI Accession #    NP_065390.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_020529.2 [Other Products]
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 UniProt Primary Accession #    P25963 [Other Products]
 UniProt Secondary Accession #    B2R8L6 [Other Products]
 UniProt Related Accession #    P25963 [Other Products]
 Molecular Weight    35,609 Da
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 NCBI Official Full Name    NF-kappa-B inhibitor alpha
 NCBI Official Synonym Full Names    NFKB inhibitor alpha
 NCBI Official Symbol    NFKBIA [Similar Products]
 NCBI Official Synonym Symbols   
IKBA; MAD-3; NFKBI
[Similar Products]
 NCBI Protein Information    NF-kappa-B inhibitor alpha
 UniProt Protein Name    NF-kappa-B inhibitor alpha
 UniProt Synonym Protein Names   
I-kappa-B-alpha; IkB-alpha; IkappaBalpha; Major histocompatibility complex enhancer-binding protein MAD3
 UniProt Gene Name    NFKBIA [Similar Products]
 UniProt Synonym Gene Names    IKBA; MAD3; NFKBI; IkB-alpha; IkappaBalpha [Similar Products]
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 NCBI Summary for IKBA    This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease. [provided by RefSeq, Aug 2011]
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 UniProt Comments for IKBA    Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.
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Product References and Citations for anti-IKBA antibody

   Béraud C, et al. (1999) Proc Natl Acad Sci U S A 96(2): 429-434. Sundström S, et al. (2005) J Virol 79(4): 2230-2239. Liu L, et al. (1998) Mol Cell Biol 18(7): 4221-4234. Shrivastava A, et al. (1998) J Virol 72(12): 9722-9728.
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 Research Articles on IKBA    1. miR-668 was upregulated in radioresistant human breast cancer cell lines MCF-7R and T-47DR, which targeted IkappaBalpha, activated the NF-kappaB pathway and thus increased the radioresistance of breast cancer cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-IKBA antibodyPathways associated with anti-IKBA antibody
 Reference Product  PubMed Publications
 NFKB1 antibody  >25 publications with IKBA and NFKB1
 RELA antibody  >13 publications with IKBA and RELA
 IKBKB antibody  >11 publications with IKBA and IKBKB
 NFKBIB antibody  >6 publications with IKBA and NFKBIB
 IKBKE antibody  >4 publications with IKBA and IKBKE
 TP53 antibody  >4 publications with IKBA and TP53
 CHUK antibody  >4 publications with IKBA and CHUK
 NFKB2 antibody  >3 publications with IKBA and NFKB2
 JAK2 antibody  >1 publications with IKBA and JAK2
 IKBKG antibody  >1 publications with IKBA and IKBKG
 Products by Pathway  Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Activation Of NF-kappaB In B Cells Pathway antibodies  Activation Of NF-kappaB In B Cells Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Modulation And Signaling Pathway antibodies  Apoptosis Modulation And Signaling Pathway Diagram
Diseases associated with anti-IKBA antibodyOrgans/Tissues associated with anti-IKBA antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >44 publications with IKBA and Neoplasms
 Inflammation Antibodies  >23 publications with IKBA and Inflammation
 Necrosis Antibodies  >11 publications with IKBA and Necrosis
 Hodgkin Disease Antibodies  >7 publications with IKBA and Hodgkin Disease
 Psoriasis Antibodies  >6 publications with IKBA and Psoriasis
 Liver Diseases Antibodies  >6 publications with IKBA and Liver Diseases
 Nervous System Diseases Antibodies  >5 publications with IKBA and Nervous System Diseases
 Drug Toxicity Antibodies  >5 publications with IKBA and Drug Toxicity
 Liver Neoplasms Antibodies  >4 publications with IKBA and Liver Neoplasms
 Neoplasms, Experimental Antibodies  >4 publications with IKBA and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >30 publications with IKBA and Blood
 Lung Antibodies  >10 publications with IKBA and Lung
 Vascular Antibodies  >9 publications with IKBA and Vascular
 Liver Antibodies  >8 publications with IKBA and Liver
 Bone Antibodies  >6 publications with IKBA and Bone
 Brain Antibodies  >5 publications with IKBA and Brain
 Skin Antibodies  >4 publications with IKBA and Skin
 Heart Antibodies  >4 publications with IKBA and Heart
 Connective Tissue Antibodies  >4 publications with IKBA and Connective Tissue
 Kidney Antibodies  >4 publications with IKBA and Kidney
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