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anti-ITGAV antibody :: Rabbit anti-Human, Mouse IntegrinalphaV Antibody

Scan QR to view Datasheet Catalog #    MBS8508164
Western Blot
Unit / Price
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IntegrinalphaV (ITGAV), Antibody

★Popular Item★
 Also Known As   

IntegrinalphaV Antibody

 Product Synonym Names    IntegrinaV Antibody; CD51; integrin alpha-V; ITAV; MSK8; vitronectin receptor alpha; VNRA
 Product Gene Name   

anti-ITGAV antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    193210
 3D Structure    ModBase 3D Structure for P06756
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 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Specificity    Integrin alphaV Antibody detects endogenous levels of total Integrin alphaV
 Purity/Purification    Immunogen affinity purified
 Form/Format    Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 C.Stable for 12 months from date of receipt
 Concentration    1mg/ml (lot specific)
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 Immunogen    A synthesized peptide derived from human Integrin alphaV
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 Preparation and Storage    Store at -20 degree C/1 year
 Other Notes    Small volumes of anti-ITGAV antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ITGAV antibody

   The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
 Applications Tested/Suitable for anti-ITGAV antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-ITGAV antibody    WB: 1:500-1:2000
IHC: 1:50-1:200
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 Western Blot of anti-ITGAV antibody    anti-ITGAV antibody Western Blot (WB) image
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NCBI/Uniprot data below describe general gene information for ITGAV. It may not necessarily be applicable to this product.
 NCBI GI #    143811408
 NCBI GeneID    3685
 NCBI Accession #    P06756.2 [Other Products]
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 UniProt Primary Accession #    P06756 [Other Products]
 UniProt Secondary Accession #    Q53SK4; Q59EB7; Q6LD15; A0AV67; B0LPF4; B7Z883; B7ZLX0; D3DPG8; E7EWZ6 [Other Products]
 UniProt Related Accession #    P06756 [Other Products]
 Molecular Weight    116 kDa [Similar Products]
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 NCBI Official Full Name    Integrin alpha-V
 NCBI Official Synonym Full Names    integrin, alpha V
 NCBI Official Symbol    ITGAV [Similar Products]
 NCBI Official Synonym Symbols   
CD51; MSK8; VNRA; VTNR
[Similar Products]
 NCBI Protein Information    integrin alpha-V; integrin alphaVbeta3; vitronectin receptor subunit alpha; antigen identified by monoclonal antibody L230; integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)
 UniProt Protein Name    Integrin alpha-V
 UniProt Synonym Protein Names   
Vitronectin receptor subunit alpha; CD_antigen: CD51Cleaved into the following 2 chains:Integrin alpha-V heavy chain; Integrin alpha-V light chain
 Protein Family    Integrin
 UniProt Gene Name    ITGAV [Similar Products]
 UniProt Synonym Gene Names    MSK8; VNRA [Similar Products]
 UniProt Entry Name    ITAV_HUMAN
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 NCBI Summary for ITGAV    This gene encodes a protein that is a member of the integrin superfamily. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein undergoes post-translational cleavage to yield disulfide-linked heavy and light chains that combine with multiple integrin beta chains to form different integrins. This protein has been shown to heterodimerize with beta 1, beta 3, beta 5, beta 6, and beta 8; the heterodimer of alpha v and beta 3 is the Vitronectin receptor. This protein interacts with several extracellular matrix proteins to mediate cell adhesion and may play a role in cell migration. It is proposed that this protein may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants that encode different protein isoforms. Note that the integrin alpha 5 and integrin alpha V chains are produced by distinct genes. [provided by RefSeq, Jan 2015]
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 UniProt Comments for ITGAV    ITGAV: The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. Belongs to the integrin alpha chain family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Cell adhesion; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 2q31-q32

Cellular Component: filopodium membrane; focal adhesion; cell surface; membrane; integral to plasma membrane; microvillus membrane; plasma membrane; phagocytic vesicle; integrin complex; external side of plasma membrane

Molecular Function: viral receptor activity; voltage-gated calcium channel activity; protein binding; opsonin binding; insulin-like growth factor I binding; protein kinase C binding; protease binding; extracellular matrix binding; transforming growth factor beta binding; metal ion binding; fibronectin binding

Biological Process: negative regulation of lipid transport; axon guidance; entry of virus into host cell; extracellular matrix organization and biogenesis; positive regulation of cell adhesion; cell-matrix adhesion; negative chemotaxis; entry of symbiont into host cell by promotion of host phagocytosis; regulation of phagocytosis; antigen processing and presentation of peptide antigen via MHC class I; positive regulation of cell proliferation; antigen processing and presentation of exogenous peptide antigen via MHC class I; angiogenesis; cell adhesion; cell growth; integrin-mediated signaling pathway; cell migration; negative regulation of lipoprotein metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; cell-substrate adhesion; heterotypic cell-cell adhesion; negative regulation of low-density lipoprotein receptor biosynthetic process; positive regulation of osteoblast proliferation; vascular endothelial growth factor receptor signaling pathway; blood coagulation; leukocyte migration; apoptotic cell clearance; positive regulation of cell migration
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 Research Articles on ITGAV    1. Results suggest that the ITGAV gene may be a candidate gene for the etiopathogenesis of rheumatoid arthritis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ITGAV antibodyPathways associated with anti-ITGAV antibody
 Reference Product  PubMed Publications
 ITGB3 antibody  >17 publications with ITGAV and ITGB3
 ITGB1 antibody  >8 publications with ITGAV and ITGB1
 ITGB5 antibody  >6 publications with ITGAV and ITGB5
 FN1 antibody  >5 publications with ITGAV and FN1
 ITGB6 antibody  >5 publications with ITGAV and ITGB6
 ITGB8 antibody  >3 publications with ITGAV and ITGB8
 VTN antibody  >2 publications with ITGAV and VTN
 CYR61 antibody  >1 publications with ITGAV and CYR61
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Processing-Cross Presentation Pathway antibodies  Antigen Processing-Cross Presentation Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies  Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
Diseases associated with anti-ITGAV antibodyOrgans/Tissues associated with anti-ITGAV antibody
 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >5 publications with ITGAV and Adenocarcinoma
 Neoplasm Metastasis Antibodies  >4 publications with ITGAV and Neoplasm Metastasis
 Liver Diseases Antibodies  >4 publications with ITGAV and Liver Diseases
 Inflammation Antibodies  >4 publications with ITGAV and Inflammation
 Neoplasm Invasiveness Antibodies  >3 publications with ITGAV and Neoplasm Invasiveness
 Carcinoma, Squamous Cell Antibodies  >3 publications with ITGAV and Carcinoma, Squamous Cell
 Lung Diseases Antibodies  >3 publications with ITGAV and Lung Diseases
 Liver Neoplasms Antibodies  >3 publications with ITGAV and Liver Neoplasms
 Necrosis Antibodies  >3 publications with ITGAV and Necrosis
 Breast Neoplasms Antibodies  >2 publications with ITGAV and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >12 publications with ITGAV and Bone
 Vascular Antibodies  >10 publications with ITGAV and Vascular
 Blood Antibodies  >7 publications with ITGAV and Blood
 Placenta Antibodies  >6 publications with ITGAV and Placenta
 Liver Antibodies  >5 publications with ITGAV and Liver
 Lymph Node Antibodies  >4 publications with ITGAV and Lymph Node
 Lung Antibodies  >4 publications with ITGAV and Lung
 Bone Marrow Antibodies  >3 publications with ITGAV and Bone Marrow
 Uterus Antibodies  >3 publications with ITGAV and Uterus
 Muscle Antibodies  >2 publications with ITGAV and Muscle
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