NP_000204.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
106,779 Da
NCBI Official Full Name
integrin beta-4 isoform 1
NCBI Official Synonym Full Names
integrin subunit beta 4
NCBI Official Synonym Symbols
NCBI Protein Information
integrin beta-4
UniProt Protein Name
Integrin beta-4
UniProt Synonym Protein Names
GP150; CD_antigen: CD104
NCBI Summary for ITB4
Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for ITB4
Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760).
Product References and Citations for anti-ITB4 antibody
Suzuki S., EMBO J. 9:757-763(1990). Hogervorst F., EMBO J. 9:765-770(1990). Tamura R.N., J. Cell Biol. 111:1593-1604(1990).
Research Articles on ITB4
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Products associated with anti-ITB4 antibody
Pathways associated with anti-ITB4 antibody
Diseases associated with anti-ITB4 antibody
Organs/Tissues associated with anti-ITB4 antibody
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