View our list of available Coronavirus (COVID-19, SARS-CoV-2, 2019-nCOV) antibodies, recombinant proteins, ELISA Kits... Options Full Datasheet Printer Friendly Datasheet Prepare for Printing Full Datasheet Printer Friendly Datasheet Prepare for Printing Have Questions? Ask Us! Request A Quote Today! Add To Compare List anti-JAG1 antibody :: Rabbit anti-Human JAG1 Antibody Catalog # MBS9400642 Unit / Price 0.1 mL / $430 +1 FREE 8GB USB 5x0.1 mL / $1,765 +2 FREE 8GB USB Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name JAG1, Antibody Full Product Name JAG1 Antibody Product Gene Name anti-JAG1 antibody[Similar Products] Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP OMIM 118450 Host Rabbit Species Reactivity Human Purity/Purification Affinity purified Form/Format PBS, pH 7.4 with 0.02% Sodium Azide Concentration 1.0 mg/ml (lot specific) Immunogen Type Recombinant Protein Immunogen Description Raised against a recombinate human JAG1 protein 469-746aa (BC126205). Target Name JAG1 Preparation and Storage This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt. Other Notes Small volumes of anti-JAG1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Product Categories/Family for anti-JAG1 antibody Total protein Ab Applications Tested/Suitable for anti-JAG1 antibody Western Blot (WB) Testing Data of anti-JAG1 antibody TOP NCBI/Uniprot data below describe general gene information for JAG1. It may not necessarily be applicable to this product. NCBI GI # 2228793 NCBI GeneID 182 NCBI Accession # AAC51731.1 [Other Products] UniProt Secondary Accession # O14902; O15122; Q15816; A0AV43; B4DYR1; E9PCF9[Other Products] UniProt Related Accession # P78504[Other Products] Molecular Weight 116,579 Da TOP NCBI Official Full Name Jagged1 NCBI Official Synonym Full Names jagged 1 NCBI Official Symbol JAG1 [Similar Products] NCBI Official Synonym Symbols AGS; AHD; AWS; HJ1; CD339; JAGL1 [Similar Products] NCBI Protein Information protein jagged-1 UniProt Protein Name Protein jagged-1 UniProt Synonym Protein Names CD_antigen: CD339 Protein Family Protein jagged UniProt Gene Name JAG1 [Similar Products] UniProt Synonym Gene Names JAGL1; Jagged1; hJ1 [Similar Products] UniProt Entry Name JAG1_HUMAN TOP NCBI Summary for JAG1 The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis. [provided by RefSeq, Jul 2008] TOP UniProt Comments for JAG1 JAG1: Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. Enhances fibroblast growth factor-induced angiogenesis (in vitro). Interacts with NOTCH2 and NOTCH3. Interacts with NOTCH1 (in the presence of calcium ions). Widely expressed in adult and fetal tissues. In cervix epithelium expressed in undifferentiated subcolumnar reserve cells and squamous metaplasia. Expression is up-regulated in cervical squamous cell carcinoma. Expressed in bone marrow cell line HS-27a which supports the long-term maintenance of immature progenitor cells.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 20p12.1-p11.23Cellular Component: membrane; apical part of cell; integral to plasma membrane; extracellular region; plasma membraneMolecular Function: protein binding; growth factor activity; calcium ion binding; Notch binding; structural molecule activityBiological Process: endothelial cell differentiation; nervous system development; Notch signaling pathway; positive regulation of myeloid cell differentiation; T cell mediated immunity; Notch receptor processing; auditory receptor cell differentiation; cell fate determination; negative regulation of fat cell differentiation; regulation of cell migration; regulation of cell proliferation; myoblast differentiation; keratinocyte differentiation; positive regulation of osteoblast differentiation; negative regulation of neuron differentiation; response to muramyl dipeptide; morphogenesis of an epithelial sheet; blood vessel remodeling; hemopoiesis; positive regulation of transcription from RNA polymerase II promoter; angiogenesis; positive regulation of Notch signaling pathwayDisease: Tetralogy Of Fallot; Alagille Syndrome 1 Research Articles on JAG1 1. Transient expression of the human cytomegalovirus tegument proteins of pp71 and UL26 reduced NICD1 and Jag1 protein levels endogenously and exogenously. TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information. TOP Products associated with anti-JAG1 antibody Reference Product PubMed Publications NOTCH1 antibody >104 publications with JAG1 and NOTCH1 DLL1 antibody >42 publications with JAG1 and DLL1 NOTCH3 antibody >36 publications with JAG1 and NOTCH3 NOTCH4 antibody >15 publications with JAG1 and NOTCH4 ADAM10 antibody >2 publications with JAG1 and ADAM10 MIB1 antibody >2 publications with JAG1 and MIB1 UBC antibody >1 publications with JAG1 and UBC Pathways associated with anti-JAG1 antibody Products by Pathway Pathway Diagram Activated NOTCH1 Transmits Signal To The Nucleus Pathway antibodies Activated NOTCH1 Transmits Signal To The Nucleus Pathway Diagram Constitutive Signaling By NOTCH1 HD Domain Mutants Pathway antibodies Constitutive Signaling By NOTCH1 HD Domain Mutants Pathway Diagram Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway antibodies Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway Diagram Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway antibodies Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway Diagram Constitutive Signaling By NOTCH1 T(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Pathway antibodies Constitutive Signaling By NOTCH1 T(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Pathway Diagram Delta-Notch Signaling Pathway antibodies Delta-Notch Signaling Pathway Diagram Disease Pathway antibodies Disease Pathway Diagram Diseases Of Signal Transduction Pathway antibodies Diseases Of Signal Transduction Pathway Diagram NOTCH2 Activation And Transmission Of Signal To The Nucleus Pathway antibodies NOTCH2 Activation And Transmission Of Signal To The Nucleus Pathway Diagram Notch Signaling Pathway antibodies Notch Signaling Pathway Diagram Diseases associated with anti-JAG1 antibody Disease Name Pubmed Publications Alagille Syndrome Antibodies >133 publications with JAG1 and Alagille Syndrome Liver Diseases Antibodies >117 publications with JAG1 and Liver Diseases Heart Defects, Congenital Antibodies >111 publications with JAG1 and Heart Defects, Congenital Facies Antibodies >34 publications with JAG1 and Facies Heart Diseases Antibodies >31 publications with JAG1 and Heart Diseases Breast Neoplasms Antibodies >24 publications with JAG1 and Breast Neoplasms Bone Diseases Antibodies >19 publications with JAG1 and Bone Diseases Chromosome Aberrations Antibodies >19 publications with JAG1 and Chromosome Aberrations Tetralogy of Fallot Antibodies >17 publications with JAG1 and Tetralogy of Fallot Brain Diseases Antibodies >17 publications with JAG1 and Brain Diseases Organs/Tissues associated with anti-JAG1 antibody Organ/Tissue Name Pubmed Publications Blood Antibodies >56 publications with JAG1 and Blood Embryonic Tissue Antibodies >34 publications with JAG1 and Embryonic Tissue Brain Antibodies >33 publications with JAG1 and Brain Kidney Antibodies >21 publications with JAG1 and Kidney Lung Antibodies >11 publications with JAG1 and Lung Placenta Antibodies >9 publications with JAG1 and Placenta Connective Tissue Antibodies >9 publications with JAG1 and Connective Tissue Pancreas Antibodies >9 publications with JAG1 and Pancreas Intestine Antibodies >6 publications with JAG1 and Intestine Ovary Antibodies >5 publications with JAG1 and Ovary TOP © 2006-24 MyBioSource.com. 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