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anti-JAK2 antibody :: JAK2 Antibody

Scan QR to view Datasheet Catalog #    MBS852339
Western Blot (WB)
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

JAK2, Antibody

★Popular Item★
 Also Known As   

JAK2 (Phospho-Tyr570) Antibody

 Product Synonym Names    EC 2.7.10.2; JAK-2; JAK2; Janus kinase 2; kinase Jak2
 Product Gene Name   

anti-JAK2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    147796
 3D Structure    ModBase 3D Structure for O60674
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 Species Reactivity    Human, Mouse, Rat
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 Specificity    JAK2 (Phospho-Tyr570) antibody detects endogenous levels of JAK2 only when phosphorylated at tyrosine 750.
 Purity/Purification    Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
 Form/Format    In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Immunogen    The antiserum was produced against synthesized phosphopeptide derived from human JAK2 around the phosphorylation site of tyrosine 750 (G-D-YP-G-Q).
 All Sites    Human: Tyr750
Mouse: Tyr750
Rat: Tyr750
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 Preparation and Storage    Store at-20 degree C for 1 year.
 Other Notes    Small volumes of anti-JAK2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-JAK2 antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-JAK2 antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-JAK2 antibody    WB: 1:500-1:1000
ELISA: 1:1000
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 Western Blot (WB) of anti-JAK2 antibody    Western blot analysis of extracts from 293 cells, treated with etoposide (25uM, 24hours), using JAK2 (Phospho-Tyr570) antibody.
anti-JAK2 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for JAK2. It may not necessarily be applicable to this product.
 NCBI GI #    1015809690
 NCBI GeneID    3717
 NCBI Accession #    NP_001309123.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001322194.1 [Other Products]
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 UniProt Primary Accession #    O60674 [Other Products]
 UniProt Secondary Accession #    O14636; O75297 [Other Products]
 UniProt Related Accession #    O60674 [Other Products]
 Molecular Weight    130,674 Da
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 NCBI Official Full Name    tyrosine-protein kinase JAK2 isoform a
 NCBI Official Synonym Full Names    Janus kinase 2
 NCBI Official Symbol    JAK2 [Similar Products]
 NCBI Official Synonym Symbols   
JTK10; THCYT3
[Similar Products]
 NCBI Protein Information    tyrosine-protein kinase JAK2
 UniProt Protein Name    Tyrosine-protein kinase JAK2
 UniProt Synonym Protein Names   
Janus kinase 2; JAK-2
 Protein Family    Tyrosine-protein kinase
 UniProt Gene Name    JAK2 [Similar Products]
 UniProt Synonym Gene Names    JAK-2 [Similar Products]
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 NCBI Summary for JAK2    This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis. [provided by RefSeq, Jul 2008]
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 UniProt Comments for JAK2    Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins (PubMed:7615558). Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins (PubMed:9618263). Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2. Once activated, dimerized STAT5 translocates into the nucleus and promotes the transcription of several essential genes involved in the modulation of erythropoiesis. Part of a signaling cascade that is activated by increased cellular retinol and that leads to the activation of STAT5 (STAT5A or STAT5B) (PubMed:21368206). In addition, JAK2 mediates angiotensin-2-induced ARHGEF1 phosphorylation (PubMed:20098430). Plays a role in cell cycle by phosphorylating CDKN1B (PubMed:21423214). Cooperates with TEC through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of 'Tyr-41' of histone H3 (H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin (PubMed:19783980).
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Product References and Citations for anti-JAK2 antibody

   Saltzman A., Biochem. Biophys. Res. Commun. 246:627-633(1998). Dalal I., Blood 91:844-851(1998). Peeters P., Blood 90:2535-2540(1997).
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 Research Articles on JAK2    1. Curcumin attenuated neuropathic pain and down-regulated the production of spinal mature IL-1beta by inhibiting the aggregation of NALP1 inflammasome and the activation of the JAK2-STAT3 cascade in astrocytes.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-JAK2 antibodyPathways associated with anti-JAK2 antibody
 Reference Product  PubMed Publications
 STAT3 antibody  >1864 publications with JAK2 and STAT3
 STAT1 antibody  >689 publications with JAK2 and STAT1
 SOCS3 antibody  >219 publications with JAK2 and SOCS3
 EPOR antibody  >218 publications with JAK2 and EPOR
 GHR antibody  >185 publications with JAK2 and GHR
 SOCS1 antibody  >179 publications with JAK2 and SOCS1
 STAT5A antibody  >169 publications with JAK2 and STAT5A
 STAT5B antibody  >166 publications with JAK2 and STAT5B
 PTPN11 antibody  >98 publications with JAK2 and PTPN11
 SH2B1 antibody  >22 publications with JAK2 and SH2B1
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Diseases associated with anti-JAK2 antibodyOrgans/Tissues associated with anti-JAK2 antibody
 Disease Name  Pubmed Publications
 Myeloproliferative Disorders Antibodies  >2264 publications with JAK2 and Myeloproliferative Disorders
 Leukemia Antibodies  >1492 publications with JAK2 and Leukemia
 Polycythemia Antibodies  >1245 publications with JAK2 and Polycythemia
 Polycythemia Vera Antibodies  >1196 publications with JAK2 and Polycythemia Vera
 Thrombocythemia, Essential Antibodies  >967 publications with JAK2 and Thrombocythemia, Essential
 Primary Myelofibrosis Antibodies  >843 publications with JAK2 and Primary Myelofibrosis
 Thrombocytosis Antibodies  >744 publications with JAK2 and Thrombocytosis
 Cardiovascular Diseases Antibodies  >622 publications with JAK2 and Cardiovascular Diseases
 Inflammation Antibodies  >402 publications with JAK2 and Inflammation
 Leukemia, Myeloid, Acute Antibodies  >388 publications with JAK2 and Leukemia, Myeloid, Acute
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >934 publications with JAK2 and Bone
 Bone Marrow Antibodies  >856 publications with JAK2 and Bone Marrow
 Vascular Antibodies  >494 publications with JAK2 and Vascular
 Liver Antibodies  >420 publications with JAK2 and Liver
 Muscle Antibodies  >334 publications with JAK2 and Muscle
 Brain Antibodies  >307 publications with JAK2 and Brain
 Spleen Antibodies  >230 publications with JAK2 and Spleen
 Kidney Antibodies  >211 publications with JAK2 and Kidney
 Lung Antibodies  >193 publications with JAK2 and Lung
 Skin Antibodies  >103 publications with JAK2 and Skin
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