Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow JAK2  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • alpha2 Macroglobulin Precursor (PRE-alpha2 MG) ELISA Kit
 • YWHAH Antibody
 • oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)... ELISA Kit
 • Serine protease inhibitor Kazal-type 3 (Spink3) Recombinant Protein
 • WAP Four-Disulfide Core Domain 2 (WFDC2) Recombinant Protein
 • interleukin 15 receptor, alpha (IL15RA) ELISA Kit
 • PARAINFLUENZA VIRUS 3 Antigen
 • Fatty Acid Binding Protein-7 (FABP7) Recombinant Protein
 • Bone Alkaline Phosphatase (BALP) ELISA Kit
 • pACCase ELISA Kit
 • OPTN cDNA Clone
 • V-set and immunoglobulin domain-containing protein 1 (Vsig1) Recombinant Protein
 • Leptomycin B Antibiotic
 • SIRPA Recombinant Protein
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-JAK2 antibody :: Rabbit JAK2 Antibody

Scan QR to view Datasheet Catalog #    MBS852339
Testing Data
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

JAK2, Antibody

★Popular Item★
 Also Known As   

JAK2 (Phospho-Tyr570) Antibody

 Product Synonym Names    EC 2.7.10.2; JAK-2; JAK2; Janus kinase 2; kinase Jak2
 Product Gene Name   

anti-JAK2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    614521
 3D Structure    ModBase 3D Structure for O60674
Section Bar
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
Section Bar
 Specificity    JAK2 (Phospho-Tyr570) antibody detects endogenous levels of JAK2 only when phosphorylated at tyrosine 750.
 Purity/Purification    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation
 Form/Format    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Section Bar
 Immunogen    The antiserum was produced against synthesized phosphopeptide derived from human JAK2 around the phosphorylation site of tyrosine 750 (G-D-YP-G-Q).
 All Sites    Human: Tyr750; Mouse: Tyr750; Rat: Tyr750
 Pathway    Phospho-specific
Section Bar
 Preparation and Storage    Store at -20 degree C for 1 year
 Other Notes    Small volumes of anti-JAK2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 Product Categories/Family for anti-JAK2 antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-JAK2 antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-JAK2 antibody    WB: 1:500~1:1000, ELISA: 1:1000
Section Bar
 Testing Data of anti-JAK2 antibody    Western blot analysis of extracts from 293 cells, treated with etoposide (25uM, 24hours), using JAK2 (Phospho-Tyr570) antibody.
anti-JAK2 antibody Testing Data image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for JAK2. It may not necessarily be applicable to this product.
 NCBI GI #    4826776
 NCBI GeneID    3717
 NCBI Accession #    NP_004963.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_004972.3 [Other Products]
Section Bar
 UniProt Primary Accession #    O60674 [Other Products]
 UniProt Secondary Accession #    O14636; O75297 [Other Products]
 UniProt Related Accession #    O60674 [Other Products]
 Molecular Weight    130,674 Da
Table BarTOPTable Bar
 NCBI Official Full Name    tyrosine-protein kinase JAK2
 NCBI Official Synonym Full Names    Janus kinase 2
 NCBI Official Symbol    JAK2 [Similar Products]
 NCBI Official Synonym Symbols   
JTK10; THCYT3
[Similar Products]
 NCBI Protein Information    tyrosine-protein kinase JAK2; JAK-2; Janus kinase 2 (a protein tyrosine kinase)
 UniProt Protein Name    Tyrosine-protein kinase JAK2
 UniProt Synonym Protein Names   
Janus kinase 2; JAK-2
 Protein Family    Tyrosine-protein kinase
 UniProt Gene Name    JAK2 [Similar Products]
 UniProt Synonym Gene Names    JAK-2 [Similar Products]
 UniProt Entry Name    JAK2_HUMAN
Section Bar
 NCBI Summary for JAK2    This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis. [provided by RefSeq, Jul 2008]
Section Bar
 UniProt Comments for JAK2    JAK2: a non-receptor tyrosine-kinase involved in a specific subset of cytokine receptor signaling pathways, including IL-3, -5 and GM-CSF. Interacts with IL23R, SKB1 and STAM2. It has been found to be constitutively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis. Fusion of Jak2 to TEL1 (ETV6) by t(9;12)(p24;p13) causes myeloproliferative disease in humans and mouse models. The Jak inhibitor AG490 inhibits constitutive Jak2 phosphorylation and causes apoptosis in cells from breast cancer and relapsing acute lymphoblastic leukemia. A single activating mutation is associated with several hematological malignancies. Inhibitor: AG490.

Protein type: EC 2.7.10.2; Kinase, protein; Protein kinase, tyrosine (non-receptor); Oncoprotein; Protein kinase, TK; TK group; JakA family

Chromosomal Location of Human Ortholog: 9p24

Cellular Component: nucleoplasm; extrinsic to internal side of plasma membrane; nuclear matrix; cytoskeleton; cytoplasm; caveola; cytosol; nucleus; lipid raft

Molecular Function: protein C-terminus binding; histone binding; non-membrane spanning protein tyrosine kinase activity; acetylcholine receptor binding; protein kinase binding; protein kinase activity; interleukin-12 receptor binding; protein binding; growth hormone receptor binding; peptide hormone receptor binding; insulin receptor substrate binding; protein-tyrosine kinase activity; heme binding; phosphoinositide 3-kinase binding; type 1 angiotensin receptor binding; SH2 domain binding; ATP binding; receptor binding

Biological Process: establishment and/or maintenance of chromatin architecture; positive regulation of nitric oxide biosynthetic process; activation of MAPKK activity; tyrosine phosphorylation of Stat3 protein; response to lipopolysaccharide; tyrosine phosphorylation of JAK2 protein; enzyme linked receptor protein signaling pathway; protein amino acid phosphorylation; positive regulation of tyrosine phosphorylation of Stat3 protein; regulation of apoptosis; response to antibiotic; elevation of cytosolic calcium ion concentration; tumor necrosis factor-mediated signaling pathway; erythrocyte differentiation; mesoderm development; negative regulation of neuron apoptosis; positive regulation of cell activation; positive regulation of DNA binding; positive regulation of protein import into nucleus, translocation; axon regeneration; positive regulation of insulin secretion; positive regulation of tumor necrosis factor production; JAK-STAT cascade; tyrosine phosphorylation of Stat5 protein; positive regulation of phosphoinositide 3-kinase cascade; tyrosine phosphorylation of STAT protein; positive regulation of peptidyl-tyrosine phosphorylation; mineralocorticoid receptor signaling pathway; response to hydroperoxide; tyrosine phosphorylation of Stat1 protein; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription factor activity; positive regulation of cell differentiation; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of phosphoprotein phosphatase activity; peptidyl-tyrosine phosphorylation; hormone-mediated signaling; negative regulation of heart contraction; apoptosis; protein amino acid autophosphorylation; platelet-derived growth factor receptor signaling pathway; signal transduction; host programmed cell death induced by symbiont; negative regulation of cell proliferation; actin filament polymerization; positive regulation of cell proliferation; cell differentiation; STAT protein nuclear translocation; caspase activation; cell migration; cytokine and chemokine mediated signaling pathway; negative regulation of DNA binding; regulation of cell proliferation; positive regulation of interleukin-1 beta production; G-protein coupled receptor protein signaling pathway; positive regulation of tyrosine phosphorylation of Stat5 protein; regulation of inflammatory response; innate immune response; negative regulation of cell-cell adhesion; blood coagulation; cell motility; induction of apoptosis by oxidative stress; positive regulation of cell migration; positive regulation of inflammatory response

Disease: Polycythemia Vera; Myelofibrosis; Budd-chiari Syndrome; Erythrocytosis, Familial, 1; Thrombocythemia 3
Table BarTOPTable Bar
 

Product References and Citations for anti-JAK2 antibody

   Saltzman A., Biochem. Biophys. Res. Commun. 246:627-633(1998).
Dalal I., Blood 91:844-851(1998).
Peeters P., Blood 90:2535-2540(1997).
Section Bar
 Research Articles on JAK2    1. Haematological neoplasms associated with t(8;9)(p22;p24); PCM1-JAK2 have features in common and we suggest that they should be recognized as a specific entity in the WHO classification
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-JAK2 antibodyPathways associated with anti-JAK2 antibody
 Reference Product  PubMed Publications
 STAT3 antibody  >1439 publications with JAK2 and STAT3
 STAT1 antibody  >629 publications with JAK2 and STAT1
 EPOR antibody  >193 publications with JAK2 and EPOR
 SOCS3 antibody  >192 publications with JAK2 and SOCS3
 GHR antibody  >173 publications with JAK2 and GHR
 SOCS1 antibody  >164 publications with JAK2 and SOCS1
 PTPN11 antibody  >102 publications with JAK2 and PTPN11
 PRLR antibody  >80 publications with JAK2 and PRLR
 CSF2RB antibody  >26 publications with JAK2 and CSF2RB
 SH2B1 antibody  >20 publications with JAK2 and SH2B1
 Products by Pathway  Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Cholinergic Synapse Pathway antibodies  Cholinergic Synapse Pathway Diagram
 Chromatin Modifying Enzymes Pathway antibodies  Chromatin Modifying Enzymes Pathway Diagram
 Chromatin Organization Pathway antibodies  Chromatin Organization Pathway Diagram
Diseases associated with anti-JAK2 antibodyOrgans/Tissues associated with anti-JAK2 antibody
 Disease Name  Pubmed Publications
 Myeloproliferative Disorders Antibodies  >1880 publications with JAK2 and Myeloproliferative Disorders
 Leukemia Antibodies  >1264 publications with JAK2 and Leukemia
 Polycythemia Antibodies  >1038 publications with JAK2 and Polycythemia
 Polycythemia Vera Antibodies  >996 publications with JAK2 and Polycythemia Vera
 Thrombocythemia, Essential Antibodies  >774 publications with JAK2 and Thrombocythemia, Essential
 Primary Myelofibrosis Antibodies  >647 publications with JAK2 and Primary Myelofibrosis
 Thrombocytosis Antibodies  >601 publications with JAK2 and Thrombocytosis
 Cardiovascular Diseases Antibodies  >502 publications with JAK2 and Cardiovascular Diseases
 Leukemia, Myeloid, Acute Antibodies  >331 publications with JAK2 and Leukemia, Myeloid, Acute
 Inflammation Antibodies  >303 publications with JAK2 and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >761 publications with JAK2 and Bone
 Bone Marrow Antibodies  >703 publications with JAK2 and Bone Marrow
 Vascular Antibodies  >423 publications with JAK2 and Vascular
 Liver Antibodies  >355 publications with JAK2 and Liver
 Muscle Antibodies  >296 publications with JAK2 and Muscle
 Brain Antibodies  >257 publications with JAK2 and Brain
 Kidney Antibodies  >182 publications with JAK2 and Kidney
 Spleen Antibodies  >181 publications with JAK2 and Spleen
 Lung Antibodies  >148 publications with JAK2 and Lung
 Skin Antibodies  >85 publications with JAK2 and Skin
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions