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anti-JNK1/2/3 antibody :: Rabbit JNK1/2/3 Antibody

Scan QR to view Datasheet Catalog #    MBS8509129
Western Blot
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

JNK1/2/3, Antibody

★Popular Item★
 Also Known As   

JNK1/2/3 Antibody

 Product Synonym Names    c-Jun N-terminal kinase 3; FLJ12099; FLJ33785; JNK3; JNK3 alpha protein kinase; JNK3A; MAP kinase 10; MAP kinase p49 3F12; MAPK 10; MAPK10; MGC50974; Mitogen-activated protein kinase 10; MK10; p493F12; p54bSAPK; PRKM10; stress activated protein kinase bet
 Product Gene Name   

anti-JNK1/2/3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601158
 3D Structure    ModBase 3D Structure for P45983
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 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    JNK1/2/3 Antibody detects endogenous levels of total JNK1/2/3
 Purity/Purification    Immunogen affinity purified
 Form/Format    Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 degree C.Stable for 12 months from date of receipt
 Concentration    50ug/50ul, 100ug/100ul (lot specific)
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 Immunogen    A synthesized peptide derived from human JNK1/2/3
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 Preparation and Storage    Store at -20 Degree C/1 year
 Other Notes    Small volumes of anti-JNK1/2/3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-JNK1/2/3 antibody

   JNK3 a protein kinase of the MAPK family that is potently activated by a variety of environmental stress and pro-inflammatory cytokines. Brain-selective JNK isoform.
 Applications Tested/Suitable for anti-JNK1/2/3 antibody   

Western Blot (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)

 Application Notes for anti-JNK1/2/3 antibody    WB: 1:500-1:2000
IF/ICC: 1:100-1:500
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 Western Blot of anti-JNK1/2/3 antibody    Western blot analysis of JNK1/2/3 expression in UV treated 293 whole cell lysates,The lane on the left is treated with the antigen-specific peptide.
anti-JNK1/2/3 antibody Western Blot (WB) image
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NCBI/Uniprot data below describe general gene information for JNK1/2/3. It may not necessarily be applicable to this product.
 NCBI GI #    2507195
 NCBI GeneID    5599
 NCBI Accession #    P45983.2 [Other Products]
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 UniProt Primary Accession #    P45983 [Other Products]
 UniProt Secondary Accession #    Q15709; Q15712; Q15713; Q308M2; B5BTZ5; B7ZLV4; D3DX88; D3DX92 [Other Products]
 UniProt Related Accession #    P45983 [Other Products]
 Molecular Weight    46+54kDa
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 NCBI Official Full Name    Mitogen-activated protein kinase 8
 NCBI Official Synonym Full Names    mitogen-activated protein kinase 8
 NCBI Official Symbol    MAPK8 [Similar Products]
 NCBI Official Synonym Symbols   
JNK; JNK1; PRKM8; SAPK1; JNK-46; JNK1A2; SAPK1c; JNK21B1/2
[Similar Products]
 NCBI Protein Information    mitogen-activated protein kinase 8; MAP kinase 8; JUN N-terminal kinase; c-Jun N-terminal kinase 1; stress-activated protein kinase 1; stress-activated protein kinase 1c; mitogen-activated protein kinase 8 isoform JNK1 beta2; mitogen-activated protein kinase 8 isoform JNK1 alpha1
 UniProt Protein Name    Mitogen-activated protein kinase 8
 UniProt Synonym Protein Names   
JNK-46; Stress-activated protein kinase 1c; SAPK1c; Stress-activated protein kinase JNK1; c-Jun N-terminal kinase 1
 UniProt Gene Name    MAPK8 [Similar Products]
 UniProt Synonym Gene Names    JNK1; PRKM8; SAPK1; SAPK1C; MAP kinase 8; MAPK 8; SAPK1c [Similar Products]
 UniProt Entry Name    MK08_HUMAN
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 NCBI Summary for JNK1/2/3    The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jun 2013]
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 UniProt Comments for JNK1/2/3    JNK1: a protein kinase of the MAPK family that is potently activated by a variety of environmental stresses, including UV and gamma radiation, ceramides, pro-inflammatory cytokines and, in some instances, by growth factors and GPCR agonists. Substrates include a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2, thus regulating AP-1 transcriptional activity. In T- cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells. Binds to at least four scaffolding proteins, JIP-1, -2, -3 and -4. Activity increased in obesity. Inhibition or mouse knockout increases insulin sensitivity. Part of NFB pathway involved in inflammation and cancer, and signals downstream of Ras, though possibly as an apoptotic negative regulator of growth. Four alternatively-spliced isoforms have been described.

Protein type: Protein kinase, CMGC; EC 2.7.11.24; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; CMGC group; MAPK family; MAPK/JNK subfamily; JNK subfamily

Chromosomal Location of Human Ortholog: 10q11.22

Cellular Component: nucleoplasm; mitochondrion; nucleus; cytosol

Molecular Function: protein serine/threonine kinase activity; protein binding; histone deacetylase regulator activity; enzyme binding; histone deacetylase binding; JUN kinase activity; ATP binding

Biological Process: nerve growth factor receptor signaling pathway; apoptosis; positive regulation of apoptosis; rhythmic process; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; protein amino acid phosphorylation; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; regulation of protein localization; regulation of transcription factor activity; JNK cascade; response to stress; negative regulation of protein binding; toll-like receptor 4 signaling pathway; response to UV; regulation of histone deacetylation; ossification; MyD88-independent toll-like receptor signaling pathway; peptidyl-threonine phosphorylation; regulation of circadian rhythm; toll-like receptor 2 signaling pathway; JUN phosphorylation; MyD88-dependent toll-like receptor signaling pathway; peptidyl-serine phosphorylation; response to cadmium ion; toll-like receptor signaling pathway; innate immune response; toll-like receptor 9 signaling pathway; negative regulation of apoptosis
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 Research Articles on JNK1/2/3    1. This study indicates that increased expression of c-Fos, p-c-Jun, members of AP-1 transcriptional factor and p-JNK is associated with neuronal degeneration in the ganglion cell layer of retinas in diabetic patients.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-JNK1/2/3 antibodyPathways associated with anti-JNK1/2/3 antibody
 Reference Product  PubMed Publications
 JUN antibody  >819 publications with JNK1/2/3 and JUN
 FOS antibody  >44 publications with JNK1/2/3 and FOS
 MAP2K4 antibody  >30 publications with JNK1/2/3 and MAP2K4
 IRS1 antibody  >23 publications with JNK1/2/3 and IRS1
 ATF2 antibody  >22 publications with JNK1/2/3 and ATF2
 MAPK8IP1 antibody  >14 publications with JNK1/2/3 and MAPK8IP1
 JUND antibody  >12 publications with JNK1/2/3 and JUND
 TP53 antibody  >7 publications with JNK1/2/3 and TP53
 JUNB antibody  >6 publications with JNK1/2/3 and JUNB
 MAPK8IP3 antibody  >4 publications with JNK1/2/3 and MAPK8IP3
 Products by Pathway  Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 ATF-2 Transcription Factor Network Pathway antibodies  ATF-2 Transcription Factor Network Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Activation Of BH3-only Proteins Pathway antibodies  Activation Of BH3-only Proteins Pathway Diagram
 Activation Of BIM And Translocation To Mitochondria Pathway antibodies  Activation Of BIM And Translocation To Mitochondria Pathway Diagram
 Activation Of BMF And Translocation To Mitochondria Pathway antibodies  Activation Of BMF And Translocation To Mitochondria Pathway Diagram
 Activation Of The AP-1 Family Of Transcription Factors Pathway antibodies  Activation Of The AP-1 Family Of Transcription Factors Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Angiopoietin Receptor Tie2-mediated Signaling Pathway antibodies  Angiopoietin Receptor Tie2-mediated Signaling Pathway Diagram
Diseases associated with anti-JNK1/2/3 antibodyOrgans/Tissues associated with anti-JNK1/2/3 antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >165 publications with JNK1/2/3 and Necrosis
 Inflammation Antibodies  >127 publications with JNK1/2/3 and Inflammation
 Nervous System Diseases Antibodies  >83 publications with JNK1/2/3 and Nervous System Diseases
 Disease Models, Animal Antibodies  >65 publications with JNK1/2/3 and Disease Models, Animal
 Liver Diseases Antibodies  >59 publications with JNK1/2/3 and Liver Diseases
 Brain Diseases Antibodies  >56 publications with JNK1/2/3 and Brain Diseases
 Reperfusion Injury Antibodies  >36 publications with JNK1/2/3 and Reperfusion Injury
 Cell Transformation, Neoplastic Antibodies  >36 publications with JNK1/2/3 and Cell Transformation, Neoplastic
 Breast Neoplasms Antibodies  >35 publications with JNK1/2/3 and Breast Neoplasms
 Heart Diseases Antibodies  >34 publications with JNK1/2/3 and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >161 publications with JNK1/2/3 and Blood
 Brain Antibodies  >140 publications with JNK1/2/3 and Brain
 Vascular Antibodies  >92 publications with JNK1/2/3 and Vascular
 Lung Antibodies  >71 publications with JNK1/2/3 and Lung
 Heart Antibodies  >69 publications with JNK1/2/3 and Heart
 Bone Antibodies  >38 publications with JNK1/2/3 and Bone
 Skin Antibodies  >37 publications with JNK1/2/3 and Skin
 Kidney Antibodies  >36 publications with JNK1/2/3 and Kidney
 Connective Tissue Antibodies  >30 publications with JNK1/2/3 and Connective Tissue
 Prostate Antibodies  >27 publications with JNK1/2/3 and Prostate
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