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anti-K6PP antibody :: K6PP Antibody

Scan QR to view Datasheet Catalog #    MBS851231
Western Blot (WB)
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

K6PP, Antibody

 Also Known As   

K6PP Antibody

 Product Synonym Names    6-phosphofructokinase type C; 6-phosphofructokinase; platelet type; EC 2.7.1.11; K6PP; PFK; platelet type; PFK-C; PFKF; phosphofructo-1-kinase isozyme C; phosphofructokinase 1; phosphohexokinase
 Product Gene Name   

anti-K6PP antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    171840
 3D Structure    ModBase 3D Structure for Q01813
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 Species Reactivity    Human, Mouse, Rat
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 Specificity    K6PP antibody detects endogenous levels of total K6PP protein.
 Purity/Purification    Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Immunogen    The antiserum was produced against synthesized peptide derived from internal of human K6PP.
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 Preparation and Storage    Store at-20 degree C for 1 year.
 Other Notes    Small volumes of anti-K6PP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-K6PP antibody    Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-K6PP antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-K6PP antibody    WB: 1:500-1:1000
ELISA: 1:1000
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 Western Blot (WB) of anti-K6PP antibody    Western blot analysis of extracts from COS-7 cells and A549 cells, using K6PP antibody.
anti-K6PP antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for K6PP. It may not necessarily be applicable to this product.
 NCBI GI #    334191701
 NCBI GeneID    5214
 NCBI Accession #    NP_001229268.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001242339.1 [Other Products]
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 UniProt Primary Accession #    Q01813 [Other Products]
 UniProt Secondary Accession #    Q5VSR7; Q5VSR8; B3KS15 [Other Products]
 UniProt Related Accession #    Q01813 [Other Products]
 Molecular Weight    85,316 Da
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 NCBI Official Full Name    ATP-dependent 6-phosphofructokinase, platelet type isoform 2
 NCBI Official Synonym Full Names    phosphofructokinase, platelet
 NCBI Official Symbol    PFKP [Similar Products]
 NCBI Official Synonym Symbols   
PFKF; PFK-C; PFK-P; ATP-PFK
[Similar Products]
 NCBI Protein Information    ATP-dependent 6-phosphofructokinase, platelet type
 UniProt Protein Name    ATP-dependent 6-phosphofructokinase, platelet type
 UniProt Synonym Protein Names   
6-phosphofructokinase type C; Phosphofructo-1-kinase isozyme C; PFK-C; Phosphohexokinase
 UniProt Gene Name    PFKP [Similar Products]
 UniProt Synonym Gene Names    PFKF; ATP-PFK; PFK-P [Similar Products]
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 NCBI Summary for K6PP    This gene encodes a member of the phosphofructokinase A protein family. The encoded enzyme is the platelet-specific isoform of phosphofructokinase and plays a key role in glycolysis regulation. This gene may play a role in metabolic reprogramming in some cancers, including clear cell renal cell carcinomas, and cancer of the bladder, breast, and lung. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
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 UniProt Comments for K6PP    Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
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Product References and Citations for anti-K6PP antibody

   Eto K., Biochem. Biophys. Res. Commun. 198:990-998(1994). Simpson C.J., Biochem. Biophys. Res. Commun. 180:197-203(1991). Beausoleil S.A., Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
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 Research Articles on K6PP    1. Here the authors show that PFK1 platelet isoform is upregulated in Glioblastoma and is required for tumor growth mechanistically, such upregulation is due to an increased stability induced by AKT activation via phosphorylation on residue S386.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-K6PP antibodyDiseases associated with anti-K6PP antibody
 Products by Pathway  Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Fructose And Mannose Metabolism Pathway antibodies  Fructose And Mannose Metabolism Pathway Diagram
 Fructose And Mannose Metabolism Pathway antibodies  Fructose And Mannose Metabolism Pathway Diagram
 Galactose Metabolism Pathway antibodies  Galactose Metabolism Pathway Diagram
 Galactose Metabolism Pathway antibodies  Galactose Metabolism Pathway Diagram
 Glucose Metabolism Pathway antibodies  Glucose Metabolism Pathway Diagram
 Glycolysis Pathway antibodies  Glycolysis Pathway Diagram
 Glycolysis (Embden-Meyerhof Pathway), Glucose => Pyruvate antibodies  Glycolysis (Embden-Meyerhof Pathway), Glucose => Pyruvate Diagram
 Glycolysis (Embden-Meyerhof Pathway), Glucose => Pyruvate antibodies  Glycolysis (Embden-Meyerhof Pathway), Glucose => Pyruvate Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >3 publications with K6PP and Neoplasms
 Disease Models, Animal Antibodies  >2 publications with K6PP and Disease Models, Animal
 Neoplasms, Experimental Antibodies  >1 publications with K6PP and Neoplasms, Experimental
 Hypertension Antibodies  >1 publications with K6PP and Hypertension
 Breast Neoplasms Antibodies  >1 publications with K6PP and Breast Neoplasms
 Carcinoma, Hepatocellular Antibodies  >1 publications with K6PP and Carcinoma, Hepatocellular
Organs/Tissues associated with anti-K6PP antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >5 publications with K6PP and Blood
 Muscle Antibodies  >4 publications with K6PP and Muscle
 Ovary Antibodies  >4 publications with K6PP and Ovary
 Liver Antibodies  >3 publications with K6PP and Liver
 Bone Antibodies  >2 publications with K6PP and Bone
 Thyroid Antibodies  >2 publications with K6PP and Thyroid
 Brain Antibodies  >2 publications with K6PP and Brain
 Heart Antibodies  >1 publications with K6PP and Heart
 Skin Antibodies  >1 publications with K6PP and Skin
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