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anti-K6PP antibody :: Rabbit K6PP Antibody

Scan QR to view Datasheet Catalog #    MBS851231
Testing Data
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

K6PP, Antibody

 Also Known As   

K6PP Antibody

 Product Synonym Names    6-phosphofructokinase type C; 6-phosphofructokinase; platelet type; EC 2.7.1.11; K6PP; PFK; platelet type; PFK-C; PFKF; phosphofructo-1-kinase isozyme C; phosphofructokinase 1; phosphohexokinase
 Product Gene Name   

anti-K6PP antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    171840
 3D Structure    ModBase 3D Structure for Q01813
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 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    K6PP antibody detects endogenous levels of total K6PP protein.
 Purity/Purification    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Immunogen    The antiserum was produced against synthesized peptide derived from internal of human K6PP.
 Pathway    Phosphatases/Kinases
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 Preparation and Storage    Store at -20 degree C for 1 year
 Other Notes    Small volumes of anti-K6PP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-K6PP antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-K6PP antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-K6PP antibody    WB: 1:500~1:1000, ELISA: 1:1000
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 Testing Data of anti-K6PP antibody    Western blot analysis of extracts from COS-7 cells and A549 cells, using K6PP antibody.
anti-K6PP antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for K6PP. It may not necessarily be applicable to this product.
 NCBI GI #    334191701
 NCBI GeneID    5214
 NCBI Accession #    NP_001229268.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001242339.1 [Other Products]
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 UniProt Primary Accession #    Q01813 [Other Products]
 UniProt Secondary Accession #    Q5VSR7; Q5VSR8; B3KS15 [Other Products]
 UniProt Related Accession #    Q01813 [Other Products]
 Molecular Weight    85,316 Da
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 NCBI Official Full Name    ATP-dependent 6-phosphofructokinase, platelet type isoform 2
 NCBI Official Synonym Full Names    phosphofructokinase, platelet
 NCBI Official Symbol    PFKP [Similar Products]
 NCBI Official Synonym Symbols   
PFKF; PFK-C; PFK-P; ATP-PFK
[Similar Products]
 NCBI Protein Information    ATP-dependent 6-phosphofructokinase, platelet type; ATP-PFK; phosphohexokinase; phosphofructokinase 1; 6-phosphofructokinase type C; phosphofructo-1-kinase isozyme C; Phosphofructokinase, platelet type
 UniProt Protein Name    ATP-dependent 6-phosphofructokinase, platelet type
 UniProt Synonym Protein Names   
6-phosphofructokinase type CPhosphofructo-1-kinase isozyme C
 UniProt Gene Name    PFKP [Similar Products]
 UniProt Synonym Gene Names    ATP-PFK; PFK-P
[Similar Products]
 UniProt Entry Name    PFKAP_HUMAN
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 NCBI Summary for K6PP    The PFKP gene encodes the platelet isoform of phosphofructokinase (PFK) (ATP:D-fructose-6-phosphate-1-phosphotransferase, EC 2.7.1.11). PFK catalyzes the irreversible conversion of fructose-6-phosphate to fructose-1,6-bisphosphate and is a key regulatory enzyme in glycolysis. The PFKP gene, which maps to chromosome 10p, is also expressed in fibroblasts. See also the muscle (PFKM; MIM 610681) and liver (PFKL; MIM 171860) isoforms of phosphofructokinase, which map to chromosomes 12q13 and 21q22, respectively. Vora (1981) [PubMed 6451249] determined that full tetrameric phophofructokinase enzyme expressed in platelets can be composed of subunits P4, P3L, and P2L2.[supplied by OMIM, Mar 2008]
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 UniProt Comments for K6PP    PFKP: phosphofructokinase, platelet type. An ubiquitous metabolic enzyme involved in the synthesis and degradation of fructose 2,6-bisphosphate. Key control step of glycolysis. An allosteric enzyme activated by ADP, AMP, or fructose bisphosphate and inhibited by ATP or citrate. Activity: ATP D-fructose 6-phosphate = ADP D-fructose 1,6-bisphosphate. The holoenzyme consists of 4 subunits. The liver and muscle enzymes are homo-tetramers of four liver or muscle isoforms, respectively. The red blood cell enzyme consists hetero-tetramers of the muscle and liver isoforms. A subunit composition with a higher proportion of platelet type subunits is found in platelets, brain and fibroblasts.

Protein type: Carbohydrate Metabolism - pentose phosphate pathway; EC 2.7.1.11; Kinase, other; Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis

Chromosomal Location of Human Ortholog: 10p15.3-p15.2

Cellular Component: membrane; nucleus; cytosol

Molecular Function: metal ion binding; protein complex binding; 6-phosphofructokinase activity; ATP binding

Biological Process: glycolysis; carbohydrate metabolic process; carbohydrate phosphorylation; glucose metabolic process; pathogenesis; fructose 6-phosphate metabolic process
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Product References and Citations for anti-K6PP antibody

   Eto K., Biochem. Biophys. Res. Commun. 198:990-998(1994).
Simpson C.J., Biochem. Biophys. Res. Commun. 180:197-203(1991).
Beausoleil S.A., Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
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 Research Articles on K6PP    1. Anti-human protein S antibody induces tissue factor expression through a direct interaction with PFKP and ERK1/2 activation in coronary artery endothelial cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-K6PP antibodyPathways associated with anti-K6PP antibody
 Reference Product  PubMed Publications
 ALDOA antibody  >4 publications with K6PP and ALDOA
 HK2 antibody  >2 publications with K6PP and HK2
 HK1 antibody  >2 publications with K6PP and HK1
 PFKFB3 antibody  >1 publications with K6PP and PFKFB3
 GPI antibody  >1 publications with K6PP and GPI
 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Fructose And Mannose Metabolism Pathway antibodies  Fructose And Mannose Metabolism Pathway Diagram
 Fructose And Mannose Metabolism Pathway antibodies  Fructose And Mannose Metabolism Pathway Diagram
 Galactose Metabolism Pathway antibodies  Galactose Metabolism Pathway Diagram
Diseases associated with anti-K6PP antibodyOrgans/Tissues associated with anti-K6PP antibody
 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >2 publications with K6PP and Disease Models, Animal
 Weight Gain Antibodies  >1 publications with K6PP and Weight Gain
 Adenocarcinoma Antibodies  >1 publications with K6PP and Adenocarcinoma
 Neoplasms, Experimental Antibodies  >1 publications with K6PP and Neoplasms, Experimental
 Hypertension Antibodies  >1 publications with K6PP and Hypertension
 Breast Neoplasms Antibodies  >1 publications with K6PP and Breast Neoplasms
 Liver Diseases Antibodies  >1 publications with K6PP and Liver Diseases
 Liver Neoplasms Antibodies  >1 publications with K6PP and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >1 publications with K6PP and Carcinoma, Hepatocellular
 Kidney Diseases Antibodies  >1 publications with K6PP and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Ovary Antibodies  >6 publications with K6PP and Ovary
 Blood Antibodies  >6 publications with K6PP and Blood
 Liver Antibodies  >4 publications with K6PP and Liver
 Muscle Antibodies  >4 publications with K6PP and Muscle
 Bone Antibodies  >2 publications with K6PP and Bone
 Thyroid Antibodies  >2 publications with K6PP and Thyroid
 Brain Antibodies  >2 publications with K6PP and Brain
 Vascular Antibodies  >1 publications with K6PP and Vascular
 Skin Antibodies  >1 publications with K6PP and Skin
 Kidney Antibodies  >1 publications with K6PP and Kidney
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