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anti-KCNT1 antibody :: Rabbit KCNT1 Antibody

Scan QR to view Datasheet Catalog #    MBS002101 anti-KCNT1 antibody
Unit / Price
0.05 mL  /  $270 +1 FREE 8GB USB
0.1 mL  /  $445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

KCNT1, Antibody

 Also Known As   

Rabbit KCNT1 Antibody

 Product Gene Name   

anti-KCNT1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 9; NC_000009.11 (138594031..138684993). Location: 9q34.3
 OMIM    608167
 3D Structure    ModBase 3D Structure for Q5JUK3
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 Host    Rabbit
 Species Reactivity    Human, mouse, rat
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 Form/Format    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
 Concentration    1 mg/ml (lot specific)
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 Other Notes    Small volumes of anti-KCNT1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-KCNT1 antibody   

Immunohistochemistry (IHC), ELISA (EIA)

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NCBI/Uniprot data below describe general gene information for KCNT1. It may not necessarily be applicable to this product.
 NCBI GI #    240255505
 NCBI GeneID    57582
 NCBI Accession #    NP_065873.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_020822.2 [Other Products]
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 UniProt Primary Accession #    Q5JUK3 [Other Products]
 UniProt Secondary Accession #    Q9P2C5; B7ZVY4; B9EGP2 [Other Products]
 UniProt Related Accession #    Q5JUK3 [Other Products]
 Molecular Weight    138,343 Da
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 NCBI Official Full Name    potassium channel subfamily T member 1 isoform 1
 NCBI Official Synonym Full Names    potassium channel, subfamily T, member 1
 NCBI Official Symbol    KCNT1 [Similar Products]
 NCBI Official Synonym Symbols   
ENFL5; SLACK; EIEE14; KCa4.1; bA100C15.2
[Similar Products]
 NCBI Protein Information    potassium channel subfamily T member 1
 UniProt Protein Name    Potassium channel subfamily T member 1
 UniProt Synonym Protein Names   
KCa4.1
 Protein Family    Potassium channel subfamily
 UniProt Gene Name    KCNT1 [Similar Products]
 UniProt Synonym Gene Names    KIAA1422 [Similar Products]
 UniProt Entry Name    KCNT1_HUMAN
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 NCBI Summary for KCNT1    Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a sodium-activated potassium channel subunit which is thought to function in ion conductance and developmental signaling pathways. Mutations in this gene cause the early-onset epileptic disorders, malignant migrating partial seizures of infancy and autosomal dominant nocturnal frontal lobe epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
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 UniProt Comments for KCNT1    KCNT1: Outwardly rectifying potassium channel subunit that may co-assemble with other Slo-type channel subunits. Activated by high intracellular sodium or chloride levels. Activated upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. May be regulated by calcium in the absence of sodium ions (in vitro). Belongs to the potassium channel family. Calcium- activated (TC 1.A.1.3) subfamily. KCa4.1/KCNT1 sub-subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Channel, potassium; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 9q34.3

Cellular Component: voltage-gated potassium channel complex

Molecular Function: voltage-gated potassium channel activity; calcium-activated potassium channel activity

Disease: Epilepsy, Nocturnal Frontal Lobe, 5; Epileptic Encephalopathy, Early Infantile, 14
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 Research Articles on KCNT1    1. Our data identify KCNT1 as a major disease-associated gene in Malignant migrating partial seizures of infancy .
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with anti-KCNT1 antibodyOrgans/Tissues associated with anti-KCNT1 antibody
 Disease Name  Pubmed Publications
 Seizures Antibodies  >3 publications with KCNT1 and Seizures
 Epilepsies, Partial Antibodies  >3 publications with KCNT1 and Epilepsies, Partial
 Brain Diseases Antibodies  >2 publications with KCNT1 and Brain Diseases
 Epilepsy, Frontal Lobe Antibodies  >2 publications with KCNT1 and Epilepsy, Frontal Lobe
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >1 publications with KCNT1 and Nerve
 Ovary Antibodies  >1 publications with KCNT1 and Ovary
 Brain Antibodies  >1 publications with KCNT1 and Brain
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